Aerodynamic characteristics of a dry powder inhaler at low inhalation flows using a mixing inlet with an Andersen Cascade Impactor

2010 ◽  
Vol 39 (5) ◽  
pp. 348-354 ◽  
Author(s):  
Dinesh Kumar Nadarassan ◽  
Khaled H. Assi ◽  
Henry Chrystyn
Keyword(s):  
Dry Powder Inhaler ◽  
Aerodynamic Characteristics ◽  
Cascade Impactor ◽  
Dry Powder ◽  
Andersen Cascade Impactor

scholarly journals The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 765
Author(s):  
Yong-Bin Kwon ◽  
Ji-Hyun Kang ◽  
Chang-Soo Han ◽  
Dong-Wook Kim ◽  
Chun-Woong Park
Keyword(s):  
Particle Size ◽  
Smooth Surface ◽  
Dry Powder Inhaler ◽  
Aerodynamic Performance ◽  
Dry Powder ◽  
Andersen Cascade Impactor ◽  
Scanning Calorimetry ◽  
Spherical Morphology ◽  
Aerodynamic Properties ◽  
Spray Dried

The purpose of this study was to prepare spray dried bosentan microparticles for dry powder inhaler and to characterize its physicochemical and aerodynamic properties. The microparticles were prepared from ethanol/water solutions containing bosentan using spray dryer. Three types of formulations (SD60, SD80, and SD100) depending on the various ethanol concentrations (60%, 80%, and 100%, respectively) were used. Bosentan microparticle formulations were characterized by scanning electron microscopy, powder X-ray diffraction, laser diffraction particle sizing, differential scanning calorimetry, Fourier-transform infrared spectroscopy, dissolution test, and in vitro aerodynamic performance using Andersen cascade impactor™ (ACI) system. In addition, particle image velocimetry (PIV) system was used for directly confirming the actual movement of the aerosolized particles. Bosentan microparticles resulted in formulations with various shapes, surface morphology, and particle size distributions. SD100 was a smooth surface with spherical morphology, SD80 was a rough surfaced with spherical morphology and SD60 was a rough surfaced with corrugated morphology. SD100, SD80, and SD60 showed significantly high drug release up to 1 h compared with raw bosentan. The aerodynamic size of SD80 and SD60 was 1.27 µm and SD100 was 6.95 µm. The microparticles with smaller particle size and a rough surface aerosolized better (%FPF: 63.07 ± 2.39 and 68.27 ± 8.99 for SD60 and SD80, respectively) than larger particle size and smooth surface microparticle (%FPF: 22.64 ± 11.50 for SD100).

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