scholarly journals Effect of Sampling Volume on Dry Powder Inhaler (DPI)-Emitted Aerosol Aerodynamic Particle Size Distributions (APSDs) Measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI)

2012 ◽  
Vol 13 (3) ◽  
pp. 875-882 ◽  
Author(s):  
Hlack Mohammed ◽  
Daryl L. Roberts ◽  
Mark Copley ◽  
Mark Hammond ◽  
Steven C. Nichols ◽  
...  
2017 ◽  
Vol 4 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Sujit K. Debnath ◽  
Saisivam Srinivasan ◽  
Monalisha Debnath

Objective:The objective of the present work was to formulate Prothionamide (PTH) nanoparticles using Poly lactic co-glycolic acid (PLGA), optimized by Box-Behnken Design and further modification to dry powder inhaler followed byin-vivostudy.Methods:Poly-lactic co-gycolic acid (PLGA), a biodegradable polymer was used to coat Prothionamide by solvent evaporation technique. Formulation was optimized using Box-Behnken Design. Response surface curve and desirability factors helped in the selection of optimum formulation of PTH nanoparticles. Dry powder inhaler was prepared by adding inhalable grade lactose to optimize PTH nanoparticles. Mass median aerodynamic diameter (MMAD) was carried out using Andersen Cascade Impactor (ACI) to demonstrate its suitability in the pulmonary administration.In-vitrodrug release of dry powder inhaler was carried out in simulated lungs fluid. Correlationin-vitrotoin-vivowas established after performing animal experiment.Results:FTIR study reveals no chemical interaction between PTH, lactose and PLGA as the principle peaks was retained with same intensity in the physical mixture. Scanning electron microscope showed the spherical shape and aerodynamic particle size was found to be 1.69µm. Drug release study showed initial burst release followed by zero order release.In-vivomodel confirmed the presence of PTH after 24h. Aerodynamic particle size and the release profile revealed the suitability of PTH loaded nanoparticles containing dry powder inhaler for the pulmonary administration.Conclusion:Prepared DPI containing PTH nanoparticles can improve in the management of tuberculosis by increasing PTH residency in the lungs tissue for prolong period of time.


Author(s):  
Max Hufnagel ◽  
Stephan Staudacher ◽  
Christian Koch

Aircraft engines are subject to deterioration due to solid particle erosion. The environmental particulates encountered in service often feature broad particle size distributions and a generally large scatter of particle properties. In order to numerically calculate the erosive change of shape of the components, experimentally calibrated erosion models are required. Due to aerodynamic and mechanical particle size effects, erosion tests with different particle size distributions have to be calibrated individually. In this study, erosion experiments under high-pressure compressor conditions are conducted using a sand-blast type erosion rig. Flat plates out of Ti6Al4V were eroded at different impingement angles. The erodent used was quartz sand with size distributions corresponding to standardized Arizona Road Dust (ARD) grades A2, A3, and A4. The particle impact conditions were investigated using a high-speed shadowgraphy technique in combination with computational fluid dynamics (CFD) computations. Dimensional analyses were carried out in respect to the particle transport process and the material removal process. A nondimensional erosion model is derived. The experimental shadowgraphy results are corrected using numerically calibrated similarity parameters for the particle impact conditions. Thus, the influence of the aerodynamic particle size effect was eliminated by correcting the impact conditions. The isolated mechanical particle size effect is demonstrated. It is shown that wear increases and that the modeled erosion rate maximum shifts toward larger impact angles when using coarser particle size distributions.


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