Enhancement pattern of small hepatocellular carcinoma (HCC) at contrast-enhanced US (CEUS), MDCT, and MRI: Intermodality agreement and comparison of diagnostic sensitivity between 2005 and 2010 American Association for the Study of Liver Diseases (AASLD) guidelines

2012 ◽  
Vol 81 (9) ◽  
pp. 2099-2105 ◽  
Author(s):  
Alessandro Furlan ◽  
Daniele Marin ◽  
Paolo Cabassa ◽  
Adele Taibbi ◽  
Elena Brunelli ◽  
...  
Hepatology ◽  
2012 ◽  
Vol 56 (3) ◽  
pp. 793-796 ◽  
Author(s):  
Morris Sherman ◽  
Jordi Bruix ◽  
Michael Porayko ◽  
Tram Tran ◽  

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Lian-Feng Liu ◽  
Zhan-Ling Ding ◽  
Jian-Hong Zhong ◽  
Hong-Xue Li ◽  
Jun-Jie Liu ◽  
...  

Objective. To evaluate contrast-enhanced ultrasound (CEUS) for monitoring early intrahepatic recurrence of primary hepatocellular carcinoma (HCC) after curative treatment. Methods. We prospectively analyzed 97 patients (124 nodules) with primary HCC who underwent hepatic resection or radiofrequency ablation and subsequently experienced intrahepatic recurrence. Patients were assessed with conventional ultrasound and CEUS. They were also assessed with contrast-enhanced computed tomography (CECT) and/or magnetic resonance imaging (MRI). The image characteristics of CEUS of recurrent hepatocellular carcinoma and high-grade dysplastic nodules (HGDNs) were analyzed. In addition, the ability of CEUS and CECT/MRI to assess internal artery vascularization in recurrent disease was compared. Results. CEUS of recurrent hepatocellular carcinoma showed hyperenhancement in the arterial phase in 96 of 99 nodules, and it showed hypo- or isoenhancement for portal venous and delayed phases. The most common enhancement patterns were “fast-in and slow-out” and “fast-in and fast-out”. Based on the arterial hyperenhancement of lesions and with clinical data such as patient history of HCC and increased level of serum alpha-fetoprotein, the diagnostic accuracy of CEUS for recurrent HCC was significantly higher than that based on the enhancement pattern of “fast-in and fast-out”. CEUS of HGDNs showed local or global hyperenhancement during the arterial phase, isoenhancement during the portal venous phase, and isoenhancement or slight hypoenhancement during the delayed phase. The enhancement pattern was “fast-in and slow-out”. In some cases, it was difficult to differentiate HGDNs from recurrent disease using CEUS. Vascularization in recurrent disease was significantly higher when assessed by CEUS than when assessed with CECT/MRI (P < 0.05). For detecting recurrent disease, CEUS showed sensitivity of 97.0%, specificity of 68.0%, positive predictive value of 92.3%, and negative predictive value of 85.0%. The corresponding parameters for CECT/MRI were 71.7%, 72.0%, 88.8%, and 39.1%. Conclusion. Intrahepatic recurrent HCC and HGDNs with diameter ≤ 3.0 cm have a characteristic appearance on CEUS. This imaging modality may be effective for monitoring early intrahepatic recurrence after curative treatment of primary HCC.


2019 ◽  
Vol 13 (1) ◽  
pp. 1-1 ◽  
Author(s):  
Jorge A. Marrero ◽  
Laura M. Kulik ◽  
Claude B. Sirlin ◽  
Andrew X. Zhu ◽  
Richard S. Finn ◽  
...  

1970 ◽  
Vol 33 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Hasnat Waheedul Hoque ◽  
Shahinul Alam ◽  
Sania Ahsan ◽  
Md. Nazrul Islam

The prevalence of hepatocellular carcinoma (HCC) in Bangladesh is 35% among all liver diseases. Sonographic examinations were performed for the evaluation of 38 cases of HCC; then, CT examina-tions were done of these cases subsequently. Expert opinion was taken in each case for both modalities. Age, sex, clinical features, location of the hepatic lesion, multiplicity, echo-character, CT density, and, contrast enhancement were evaluated in all cases. Histocytopathology reports were collected from the patients and were correlated with the ultrasonography and CT findings. Thirty five cases were detected as HCC on ultrasonography and 36 cases in CT scan. In ultrasonography, most of the lesions (82.9%) were found in right lobe, maximum lesions (45.7%) were hypoechoic and lesion showed mosaic pattern in 68.6% cases, lateral shadowing in 34.3% and posterior acoustic enhancement in 45.7% cases. Significant difference found between mosaic pattern and lateral shadowing (p<0.05). On CT scan, majority of lesions (50%) were hypodense, 91.7% lesions were contrast enhanced. Pattern of enhancement was mostly heterogeneous. Both of the modalities found sensitive but CT was found more sensitive, specific and accurate than ultrasonography in detecting HCC.  Keywords: Computer tomography; Cytohistopathological; Hepatocellular carcinoma; UltrasonographyDOI: 10.3329/bmrcb.v33i2.1209Bangladesh Med Res Counc Bull 2007; 33: 73-77 


2015 ◽  
Vol 30 (2) ◽  
pp. 345-351 ◽  
Author(s):  
Ming-Tsung Lin ◽  
Kuo-Chin Chang ◽  
Yeh-Pin Chou ◽  
Po-Lin Tseng ◽  
Yi-Hao Yen ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document