Dual-energy computed tomography for characterizing urinary calcified calculi and uric acid calculi: A meta-analysis

2016 ◽  
Vol 85 (10) ◽  
pp. 1843-1848 ◽  
Author(s):  
Xingju Zheng ◽  
Yuanyuan Liu ◽  
Mou Li ◽  
Qiyan Wang ◽  
Bin Song
Keyword(s):  
Computed Tomography ◽  
Uric Acid ◽  
Meta Analysis ◽  
Dual Energy ◽  
Dual Energy Computed Tomography

Diagnostic accuracy of dual-energy computed tomography (DECT) to differentiate uric acid from non-uric acid calculi: systematic review and meta-analysis

2020 ◽  
Vol 30 (5) ◽  
pp. 2791-2801 ◽  
Author(s):  
Trevor A. McGrath ◽  
Robert A. Frank ◽  
Nicola Schieda ◽  
Brian Blew ◽  
Jean-Paul Salameh ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systematic Review ◽  
Uric Acid ◽  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
Dual Energy ◽  
Dual Energy Computed Tomography

Diagnostic Accuracy of Dual-Energy CT in Detection of Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 084653712090206 ◽  
Author(s):  
Waleed Abdellatif ◽  
Mahmoud Ahmed Ebada ◽  
Souad Alkanj ◽  
Ahmed Negida ◽  
Nicolas Murray ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systematic Review ◽  
Pulmonary Embolism ◽  
Diagnostic Accuracy ◽  
Likelihood Ratio ◽  
Acute Pulmonary Embolism ◽  
Meta Analysis ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Sensitivity Specificity

Purpose: In this systematic review and meta-analysis, we aimed to investigate the accuracy of dual-energy computed tomography (DECT) in the detection of acute pulmonary embolism (PE). Methods: We searched Medline (via PubMed), EBSCO, Web of Science, Scopus, and the Cochrane Library for relevant published studies. We selected studies assessing the accuracy of DECT in the detection of PE. Quality assessment of bias and applicability was conducted using the Quality of Diagnostic Accuracy Studies-2 tool. Meta-analysis was performed to calculate mean estimates of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR). The summary receiver operating characteristic (sROC) curve was drawn to get the Cochran Q-index and the area under the curve (AUC). Results: Seven studies were included in our systematic review. Of the 182 patients included, 108 patients had PEs. The pooled analysis showed an overall sensitivity and specificity of 88.9% (95% confidence interval [CI]: 81.4%-94.1%) and 94.6% (95% CI: 86.7%-98.5%), respectively. The pooled PLR was 8.186 (95% CI: 3.726-17.986), while the pooled NLR was 0.159 (95% CI: 0.093-0.270). Cochran-Q was 0.8712, and AUC was 0.935 in the sROC curve. Conclusion: Dual-energy computed tomography shows high sensitivity, specificity, and diagnostic accuracy in the detection of acute PE. The high PLR highlights the high clinical importance of DECT as a prevalence-independent, rule-in test. Studies with a larger sample size with standardized reference tests are still needed to increase the statistical power of the study and support these findings.

scholarly journals Dual-energy computed tomography for the differentiation of uric acid stones: ex vivo performance evaluation

2008 ◽  
Vol 36 (3-4) ◽  
pp. 133-138 ◽  
Author(s):  
Paul Stolzmann ◽  
Hans Scheffel ◽  
Katharina Rentsch ◽  
Thomas Schertler ◽  
Thomas Frauenfelder ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Uric Acid ◽  
Performance Evaluation ◽  
Ex Vivo ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Uric Acid Stones

scholarly journals OP0318 THE ROLE OF DUAL ENERGY COMPUTED TOMOGRAPHY (DECT) IN THE DIFFERENTIATION OF GOUT AND CALCIUM PYROPHOSPHATE DEPOSITION DISEASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 196.2-196 ◽  
Author(s):  
D. Kravchenko ◽  
P. Karakostas ◽  
P. Brossart ◽  
C. Behning ◽  
C. Meyer ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Uric Acid ◽  
Sensitivity And Specificity ◽  
Gold Standard ◽  
Calcium Pyrophosphate ◽  
Dual Energy ◽  
Laboratory Parameters ◽  
Dual Energy Computed Tomography ◽  
Non Invasive ◽  
Calcium Pyrophosphate Deposition Disease

Background:Differentiation of gout and calcium pyrophosphate deposition disease (CPPD) is sometimes difficult as patients often present with a similar clinical picture. Arthrocentesis and subsequent polarization microscopy (PM) remains the gold standard but novel diagnostic approaches such as non-invasive dual energy computed tomography (DECT) have recently been validated for gout. Currently, limited data is available on DECT in patients with CPPD.Objectives:To analyse the diagnostic impact of DECT in gout and CPPD when compared to the gold standard of PM. We further compared the results of PM to ultrasound (US), conventional radiographs (CR), and suspected clinical diagnosis (SCD). Additionally, 15 laboratory parameters were analysed.Methods:Twenty-six patients diagnosed with gout (n = 18) or CPPD (n = 8) who received a DECT and underwent arthrocentesis were included. Two independent readers assessed colour coded, as well as 80 and 120 kV DECT images for signs of monosodium urate (MSU) crystals or CPP deposition. US and CR from the patient’s initial visit along with the SCD were also compared to PM. US examinations were performed by certified musculoskeletal ultrasound specialists. The association of up to 15 laboratory parameters such as uric acid, thyroid stimulating hormone, and C-reactive protein (CRP) with the PM results was analysed.Results:Sensitivity of DECT for gout was 67% (95% CI 0.41-0.87) with a specificity of 88% (95% CI 0.47-1.0). Concerning CPPD, the sensitivity and specificity of DECT was 63% (95% CI 0.25-0.91) and 83% (95% CI 0.59-0.96) respectively. US had the highest sensitivity of 89% (95% CI 0.65-0.99) with a specificity of 75% (95% CI 0.35-0.97) for gout, while the sensitivity and specificity for CPPD were 88% (95% CI 0.47-1.0) and 89% (95% CI 0.65-0.99) respectively. The SCD had the second highest sensitivity for gout at 78% (95% CI 0.52-0.94) with a comparable sensitivity of 63% (95% CI 0.25-0.92) for CPPD. Uric acid levels were elevated in 33% of gout patients and 25% of CPPD patients. While elevated CRP levels were observed in 59% of gout patients and in 88% of CPPD patients, none of the 15 analysed laboratory parameters were found to be significantly linked.Conclusion:DECT provides a non-invasive diagnostic tool for gout but might have a lower sensitivity than suggested by previous studies (67% vs 90%1). DECT sensitivity for CPPD was 63% (95% CI 0.25-0.91) in a sample group of eight patients. Both US and the SCD had higher sensitivities than DECT for gout and CPPD. Further studies with larger patient cohorts are needed in order to determine the diagnostic utility of DECT in CPPD.References:[1]Bongartz, Tim; Glazebrook, Katrina N.; Kavros, Steven J.; Murthy, Naveen S.; Merry, Stephen P.; Franz, Walter B. et al. (2015): Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study. InAnnals of the rheumatic diseases74 (6), pp. 1072–1077. DOI: 10.1136/annrheumdis-2013-205095.Disclosure of Interests:None declared

scholarly journals Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography

2020 ◽  
Vol 12 (8) ◽  
pp. 184-194
Author(s):  
Sharon Hannah Barazani ◽  
Wei-Wei Chi ◽  
Renata Pyzik ◽  
Helena Chang ◽  
Adam Jacobi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Uric Acid ◽  
Dual Energy ◽  
Dual Energy Computed Tomography
Sign in / Sign up

Export Citation Format

Share Document