Radiation dose in cone beam CT guided ERCP

2020 ◽  
Vol 123 ◽  
pp. 108789
Author(s):  
Alexander Waldthaler ◽  
Marcus Reuterwall-Hansson ◽  
Urban Arnelo ◽  
Nils Kadesjö
2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15654-e15654
Author(s):  
J. Yue ◽  
J. Yu ◽  
S. LI ◽  
Y. Yin ◽  
T. Liu ◽  
...  

e15654 Background: The radiation dose is the key factor to improve survival of patients with hepatocellular carcinoma (HCC). The optimal way to increase radiation dose is to reduce uncertainties of target mainly due to respiratory motion and setup error in radiotherapy. Our previous study demonstrated that lipiodol can be a reliable surrogate of direct tumor targeting in Kv- cone beam CT(CBCT) for patients with good lipiodol embolization. Relying on lipiodol,the daily on-line CBCT guidance with ABC is feasible. By reducing geometric position uncertainty, as well as liver movement, the technique of ABC combined with on-line CBCT guidance can permit CTV(clinical target volume)-PTV(planning target volume) margin reduction and dose escalation. The purpose of the study is to apply the new technique for clinical application and investigate the dose escalation, toxicities and response of liver tumors with the technique combined with chemoembolization(TACE). Methods: 20 HCC patients with Child-Pugh A liver function score were treated by daily on-line CBCT guided radiotherapy relying on lipiodol combined with ABC after TACE. After current doses of 45Gy/ 9 fractions,3 fractions/weeks were delivered,the scheduled dose escalation ranged from 5 to 20Gy. Each mean liver dose not reached 23G y, V30 ( the percentage of normal liver volume with radiation dose≥30 Gy) less than 28%. Results: The planned dose escalation was finished in all subgroups. None of these patients developed Grade 2 or greater liver toxicity except two patients developed Grade 2 gastrointestinal complications and one had grade 1 acute liver toxicity.The overall immediate tumor response rate was 76.3%. 1-year overall survival rate was 80.5%. Conclusions: The technique of daily on-line CBCT guided radiotherapy combined with ABC after TACE is a safe and effective treatment which can reduce CTV-PTV margin significantly and increase target precision greatly. With the technique combined with TACE, the total irradiation dose above 65Gy is feasible in daily fraction of 5Gy. No significant financial relationships to disclose.


2021 ◽  
Vol 85 ◽  
pp. 192-199
Author(s):  
Julia Rousseau ◽  
Serge Dreuil ◽  
Céline Bassinet ◽  
Sophie Cao ◽  
Hélène Elleaume

2015 ◽  
Vol 114 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Weigang Hu ◽  
Guichao Li ◽  
Jinsong Ye ◽  
Jiazhou Wang ◽  
Jiayuan Peng ◽  
...  

Radiology ◽  
2019 ◽  
Vol 290 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Charles Roux ◽  
Lambros Tselikas ◽  
Steven Yevich ◽  
Raphael Sandes Solha ◽  
Antoine Hakime ◽  
...  

2020 ◽  
Vol 49 (6) ◽  
pp. 20190495 ◽  
Author(s):  
Durer Iskanderani ◽  
Mats Nilsson ◽  
Per Alstergren ◽  
Xie-Qi Shi ◽  
Kristina Hellen-halme

Objective: Evaluation of cone beam CT (CBCT) examination with a low-dose scanning protocol for assessment of the temporomandibular joint (TMJ). Methods: 34 adult patients referred for CBCT imaging of the TMJ underwent two examinations with two scanning protocols, a manufacturer-recommended protocol (default) and a low-dose protocol where the tube current was reduced to 20% of the default protocol. Three image stacks were reconstructed: default protocol, low-dose protocol, and processed (using a noise reduction algorithm) low-dose protocol. Four radiologists evaluated the images. The Sign test was used to evaluate visibility of TMJ anatomic structures and image quality. Receiver operating characteristic analyzes were performed to assess the diagnostic accuracy. κ values were used to evaluate intraobserver agreement. Results: With the low-dose and processed protocols, visibility of the TMJ anatomical structures and overall image quality were comparable to the default protocol. No significant differences in radiographic findings were found for the two low-dose protocols compared to the default protocol. The area under the curves (Az) averaged for the low-dose and processed protocols, according to all observers, were 0.931 and 0.941, respectively. Intraobserver agreement was good to very good. Conclusion: For the CBCT unit used in this study, the low-dose CBCT protocol for TMJ examination was diagnostically comparable to the manufacturer-recommended protocol, but delivered a five times lower radiation dose. There is an urgent need to evaluate protocols for CBCT examinations of TMJ in order to optimize them for a radiation dose as low as diagnostically acceptable (the as low as diagnostically acceptable principle recommended by NCRP).


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