421. Correlations of human epithelial growth factor receptor 2 (HER2) overexpression with MUC2, MUC5AC, MUC6, p53, and clinicopathological characteristics in gastric cancer patients

2014 ◽  
Vol 40 (11) ◽  
pp. S161
Author(s):  
K. Park ◽  
H.K. Jang ◽  
S.I. Yang ◽  
Y.M. Shin
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Cancer Patients ◽  
Growth Factor Receptor ◽  
Clinicopathological Characteristics ◽  
Epithelial Growth Factor Receptor ◽  
Her2 Overexpression ◽  
Epithelial Growth Factor ◽  
Gastric Cancer Patients ◽  
Epithelial Growth

scholarly journals Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Kwang Kuk Park ◽  
Song I Yang ◽  
Kyung Won Seo ◽  
Ki Young Yoon ◽  
Sang Ho Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Growth Factor Receptor ◽  
Clinicopathological Characteristics ◽  
Her2 Overexpression ◽  
Her2 Expression ◽  
Her2 Positive ◽  
Poor Prognostic Factor ◽  
P53 Expression ◽  
Gastric Cancer Patients

Background. The purpose of this study was to evaluate the relationships between HER2 overexpression in the tumor and MUC2, MUC5AC, MUC6, and p53 status and clinicopathological characteristics of gastric cancer patients.Methods. This retrospective study included 282 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between April 2011 and December 2012. All tumor samples were examined for HER2 expression by immunohistochemistry (IHC) and MUC2, MUC5AC, MUC6, and p53 expression by staining. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors.Results. The HER2-positive rate was 18.1%. Although no association was found between HER2 expression and MUC5AC, the expression of MUC2, MUC6, and p53 was significantly correlated with HER2 positivity, respectively (P= 0.004, 0.037, 0.002). Multivariate analysis revealed that HER2 overexpression and nodal status were independent prognostic factors.Conclusions. HER2 overexpression in gastric carcinoma is an independent poor prognostic factor.

Oxidative Stress Induces Arachidonate Release from Human Lung Cells through the Epithelial Growth Factor Receptor Pathway

2002 ◽  
Vol 27 (6) ◽  
pp. 722-731 ◽  
Author(s):  
Rafal Pawliczak ◽  
Xiu-Li Huang ◽  
Uday B. Nanavaty ◽  
Marion Lawrence ◽  
Patricia Madara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Human Lung ◽  
Growth Factor Receptor ◽  
Epithelial Growth Factor Receptor ◽  
Lung Cells ◽  
Epithelial Growth Factor ◽  
Human Lung Cells ◽  
Arachidonate Release ◽  
Epithelial Growth

Prostasin Impairs Epithelial Growth Factor Receptor Activation to Suppress Dengue Virus Propagation

2018 ◽  
Vol 219 (9) ◽  
pp. 1377-1388 ◽  
Author(s):  
Chun-Kuang Lin ◽  
Chin-Kai Tseng ◽  
Yu-Hsuan Wu ◽  
Chun-Yu Lin ◽  
Chung-Hao Huang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dengue Virus ◽  
Growth Factor Receptor ◽  
Receptor Activation ◽  
Epithelial Growth Factor Receptor ◽  
Virus Propagation ◽  
Epithelial Growth Factor ◽  
Epithelial Growth

scholarly journals Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769101 ◽  
Author(s):  
Dandan Tong ◽  
Ya-Nan Liang ◽  
AA Stepanova ◽  
Yu Liu ◽  
Xiaobo Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Epithelial Growth Factor Receptor ◽  
Epithelial Growth Factor ◽  
Epidermal Growth ◽  
Epithelial Growth ◽  
Eps15 Homology Domain

Recent research indicates that the C-terminal Eps15 homology domain 1 is associated with epithelial growth factor receptor–mediated endocytosis recycling in non-small-cell lung cancer. The aim of this study was to determine the clinical significance of Eps15 homology domain 1 gene expression in relation to phosphorylation of epithelial growth factor receptor expression in patients with breast cancer. Primary breast cancer samples from 306 patients were analyzed for Eps15 homology domain 1, RAB11FIP3, and phosphorylation of epithelial growth factor receptor expression via immunohistochemistry. The clinical significance was assessed via a multivariate Cox regression analysis, Kaplan–Meier curves, and the log-rank test. Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor were upregulated in 60.46% (185/306) and 53.92% (165/306) of tumor tissues, respectively, as assessed by immunohistochemistry. The statistical correlation analysis indicated that Eps15 homology domain 1 overexpression was positively correlated with the increases in phosphorylation of epithelial growth factor receptor ( r = 0.242, p < 0.001) and RAB11FIP3 ( r = 0.165, p = 0.005) expression. The multivariate Cox proportional hazard model analysis demonstrated that the expression of Eps15 homology domain 1 alone is a significant prognostic marker of breast cancer for the overall survival in the total, chemotherapy, and human epidermal growth factor receptor 2 (−) groups. However, the use of combined expression of Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor markers is more effective for the disease-free survival in the overall population, chemotherapy, and human epidermal growth factor receptor 2 (−) groups. Moreover, the combined markers are also significant prognostic markers of breast cancer in the human epidermal growth factor receptor 2 (+), estrogen receptor (+), and estrogen receptor (−) groups. Eps15 homology domain 1 has a tumor suppressor function, and the combined marker of Eps15 homology domain 1/phosphorylation of epithelial growth factor receptor expression was identified as a better prognostic marker in breast cancer diagnosis. Furthermore, RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor.

Expression of human epidermal growth factor receptor 2 and p53 in gastric cancer patients: Clinical and prognosis relevance

2016 ◽  
Vol 5 (5) ◽  
pp. 424
Author(s):  
Raja Gargouri ◽  
DorraBen Ayed-Guerfali ◽  
Najla Abid ◽  
Abdelmajid Khabir ◽  
Hela Mnif ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Patients ◽  
Growth Factor Receptor ◽  
Human Epidermal Growth Factor ◽  
Epidermal Growth ◽  
Gastric Cancer Patients

scholarly journals A short interval between bevacizumab and anti-epithelial growth factor receptor therapy interferes with efficacy of subsequent anti-EGFR therapy for refractory colorectal cancer

2016 ◽  
Vol 46 (3) ◽  
pp. 228-233 ◽  
Author(s):  
Hiroya Taniguchi ◽  
Azusa Komori ◽  
Yukiya Narita ◽  
Shigenori Kadowaki ◽  
Takashi Ura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Short Interval ◽  
Growth Factor Receptor ◽  
Epithelial Growth Factor Receptor ◽  
Epithelial Growth Factor ◽  
Epithelial Growth
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