Liposarcoma are frequently seen in the retroperitoneum. It is of four types pathologically: Well-differentiated, dedifferentiated, myxoid and pleomorphic. Well-differentiated is the most common type. Dedifferentiated has the worst prognosis. Reports of Liposarcoma arising from the intraperitoneal sites such as stomach, omentum, mesentery and sigmoid mesocolon are rare. A 47 year old gentleman presented with pain in abdomen and abdominal distention, had a provisional diagnosis of GIST, intra-peritoneal liposarcoma. Imaging revealed a well-defined encapsulated abdominal mass indicative of liposarcoma with fibrous differentiation/fibro-lipoma. On surgery a well encapsulated mass was excised completely arising from the greater curvature of stomach. The mass on histopathological examination indicated features suggestive of liposarcoma (well-differentiated) with IHC markers positive for S100, CDK4 and MDM2. A diagnosis of intraperitoneal liposarcoma form greater curvature of stomach was made. This was an exceedingly rare presentation of liposarcoma arising from the greater curvature of stomach with differential diagnosis of GIST which was ruled out with histopathological features and negative CD117 and CD34. Thus to conclude liposarcoma being quite common retroperitoneal tumor, has an exceedingly rare occurrence from intraperitoneal sites and should be taken as an exceedingly rare differential diagnosis for mass per abdomen.
Soft Tissue Myxoma- A Rare Differential Diagnosis of Localized Oral Cavity Lesions
