Clinicopathological Profile of Thyroid Carcinoma in Young Patients: An Indonesian Single-Center Study

Introduction. Thyroid cancer is the third most common cancer that occurs in children and adolescents. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Although the mortality rate of thyroid malignancy in children is usually low, the disease recurrence is higher in children with more severe clinical presentation than in adults. This study aimed to determine the demographic and clinicopathological characteristics and outcome of pediatric and adolescent patients with thyroid malignancy in Indonesia. Methods. The retrospective study included all patients diagnosed with thyroid carcinoma aged <20 years, from January 1, 2015, to December 31, 2019. Twenty-nine subjects fulfilled the inclusion and exclusion criteria. We retrieved baseline characteristics, pathology features, TSH and fT4 status, radioactive iodine therapy data, and patients’ outcomes. Then, data were analyzed using the chi-square or Fisher’s exact method. Results. We identified 29 eligible subjects, including 3 boys and 26 girls. The most common type of thyroid carcinoma was PTC (96.5%), and follicular type (31%) was the predominant variant of PTC. Lymph node involvement occurred in 24% of patients, while distant metastasis occurred in 17.2% of patients with PTC. Twenty-four (82.7%) patients had stage 1 disease. Disease recurrence was recorded in 31% of patients during the study period with a median follow-up time of 24 months. Conclusion. PTC is the most frequent type of thyroid carcinoma among children and adolescents. This malignancy has a low mortality rate, but the recurrence rate remains high among younger patients than adults even during a short-term follow-up analysis. Distant metastasis and lymph node involvement are commonly found in this age group.

CaCO3 Polymorphs Used as Additives in Filament Production for 3D Printing

Nowadays, additive manufacturing—also called 3D printing—represents a well-established technology in the field of the processing of various types of materials manufacturing products used in many industrial sectors. The most common type of 3D printing uses the fused filament fabrication (FFF) method, in which materials based on thermoplastics or elastomers are processed into filaments. Much effort was dedicated to improving the properties and processing of such printed filaments, and various types of inorganic and organic additives have been found to play a beneficial role. One of them, calcium carbonate (CaCO3), is standardly used as filler for the processing of polymeric materials. However, it is well-known from its different applications that CaCO3 crystals may represent particles of different morphologies and shapes that may have a crucial impact on the final properties of the resulting products. For this reason, three different synthetic polymorphs of CaCO3 (aragonite, calcite, and vaterite) and commercially available calcite powders were applied as fillers for the fabrication of polymeric filaments. Analysis of obtained data from different testing techniques has shown significant influence of filament properties depending on the type of applied CaCO3 polymorph. Aragonite particles showed a beneficial impact on the mechanical properties of produced filaments. The obtained results may help to fabricate products with enhanced properties using 3D printing FFF technology.

Advances of Genomic Medicine in Psoriatic Arthritis

Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible structural damage, there are no adequate screening tools for this purpose, and there are no clear markers of predisposition to the disease. Much evidence indicates that PsA disorder is complex and heterogeneous, where genetic and environmental factors converge to trigger inflammatory events and the development of the disease. Nevertheless, the etiologic events that underlie PsA are complex and not completely understood. In this review, we describe the existing data in PsA in order to highlight the need for further research in this disease to progress in the knowledge of its pathobiology and to obtain early diagnosis tools for these patients.

Synthesis, Characterization and Cytotoxic Activity Studies on Cancer Cell Lines of New Paraben Decorated Monospiro-Cyclotriphosphazenes

Cancer is one of the leading causes of death worldwide. Among the causes of cancer-related deaths in women, breast cancer, which is the most common type of cancer in women,...

Using virtual reality (VR) simulation to help developing a smart meeting space with AI Product to support moderator

Smart building has a pivotal role in promoting the industrialization of buildings. Meeting room is a common type of public space. Developing a smart meeting space can play an important role in addressing the issue of research on smart building. In this paper, we develop a smart meeting space with AI product to support moderator. We create 3D model of the meeting room and import it into VR headset to having an experiment. 20 participants are engaged to answer questionnaire and have interview. The results of this study show that most of the participants think the meeting space we develop is smart than usual one. We also found that participants expect functions of smart meeting room in AI assistance, energy saving, smart display solution, remote meeting. And participants expect devices of smart meeting room in AI assistance product, sensors, and devices for remote meeting.

Guillain-Barré Syndrome During the COVID-19 Pandemic and Pre-pandemic Periods

Background: Guillain-Barré Syndrome (GBS) is an autoimmune disease that may occur after infections. As Coronavirus Disease 2019 (COVID-19) may bring about GBS, it is important to assess the effect of the COVID-19 pandemic on this disease Objectives: This study aimed to compare the distribution and characteristics of GBS during and before the COVID-19 pandemic in an academic referral hospital in the north of Iran. Materials & Methods: This retrospective study assessed GBS distribution and characteristics during the COVID-19 pandemic period (from March 2020 to the end of February 2021) and before the pandemic (from March 2019 to the end of February 2020) on 5340 patients referred to the Neurology Ward of Poursina Hospital of Guilan Province, in Iran. Results: There was no significant difference between GBS distribution during (0.03%) and before (0.04%) the COVID-19 pandemic (P=0.413). There were also no differences between the two periods regarding the gender (P=0.659) and age (P=0.417) of the patients. The most common subtype of GBS during the COVID-19 pandemic was Acute Motor and Sensory Axonal Neuropathy (AMSAN) (71.4%). In both periods, the most common type of treatment was intravenous administration of immune globulin. There was no significant difference between the two periods (P=0.838) regarding the patients’ treatment response. Conclusion: The distribution of GBS, its subtypes, type of treatment, and response to treatment were not different between the two study periods.

They Won't Teach You This in School

Diabetes mellitus (DM) has shown growing global morbidity, thus becoming a public health priority. In 2017, approximately 425 million people suffered from diabetes, and it is estimated that by 2045 the number will increase to 629 million. Type 2 diabetes mellitus (DM2), with 90% of reported cases, is the most common type and is followed by type 1. In 2018, 8.6 million people over 20 years of age were diagnosed with diabetes in Mexico. This represents 10.6% of the population. In some states with a higher incidence such as Nuevo León, it is estimated that 12.6% of the population above 20 years has been diagnosed with DM. This chapter seeks to inform about type 2 Diabetes Mellitus, its way of acting and complications that it entails, and how social media can be advantageous in patient education.

Ethics in nursing: categorization of legal processes

ABSTRACT Objectives: to categorize factual elements of ethical-disciplinary nursing lawsuits in the state of Goiás. Methods: cross-sectional, retrospective study, based on secondary data obtained from ethical-disciplinary lawsuits filed at the Regional Nursing Council of Goiás (Coren-Goiás) between the years 2010 and 2019. Results: the highest number of lawsuits filed was in 2013 and 2014, with a greater frequency in the state capital. The majority came from the Nursing Ethics Committees and ex-officio complaints. The professional with most complaints was the nursing technician, aged between 31 and 40 years old, at the beginning of their career. The most common type of complaints referred to performing attributions that were not within the nursing competences. Conclusions: as a highlight are the contributions of this study to professional ethics in nursing and the clear need to consolidate these skills in nurses who are in training and in the continuous education for those already in the profession.

The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment

Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the regulation of mitochondria-mediated apoptosis, Ca2+ homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy.