scholarly journals Preoperative multidisciplinary team assessment is associated with improved survival in patients with locally advanced colon cancer; a nationwide cohort study in 3157 patients

2021 ◽  
Author(s):  
E. Rosander ◽  
T. Holm ◽  
A. Sjövall ◽  
F. Hjern ◽  
C.E. Weibull ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Multidisciplinary Team ◽  
Locally Advanced ◽  
Advanced Colon Cancer ◽  
Team Assessment

Concomitant Adjacent Organ Resection in Locally Advanced Colon Cancer

2009 ◽  
Vol 25 (2) ◽  
pp. 94 ◽  
Author(s):  
Sung Wook Cho ◽  
Ryung-Ah Lee ◽  
Soon Sup Chung ◽  
Kwang Ho Kim
Keyword(s):  
Colon Cancer ◽  
Locally Advanced ◽  
Adjacent Organ ◽  
Advanced Colon Cancer

scholarly journals Differences in effectiveness and use of laparoscopic surgery in locally advanced colon cancer patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
M. Schootman ◽  
Matthew Mutch ◽  
T. Loux ◽  
J. M. Eberth ◽  
N. O. Davidson
Keyword(s):  
Colon Cancer ◽  
Length Of Stay ◽  
Cancer Patients ◽  
Postoperative Ileus ◽  
Locally Advanced ◽  
Composite Outcome ◽  
Improvement Program ◽  
Advanced Colon Cancer ◽  
Outcome Score ◽  
T4 Colon Cancer

AbstractPatients with locally advanced colon cancer have worse outcomes. Guidelines of various organizations are conflicting about the use of laparoscopic colectomy (LC) in locally advanced colon cancer. We determined whether patient outcomes of LC and open colectomy (OC) for locally advanced (T4) colon cancer are comparable in all colon cancer patients, T4a versus T4b patients, obese versus non-obese patients, and tumors located in the ascending, descending, and transverse colon. We used data from the 2013–2015 American College of Surgeons’ National Surgical Quality Improvement Program. Patients were diagnosed with nonmetastatic pT4 colon cancer, with or without obstruction, and underwent LC (n = 563) or OC (n = 807). We used a composite outcome score (mortality, readmission, re-operation, wound infection, bleeding transfusion, and prolonged postoperative ileus); length of stay; and length of operation. Patients undergoing LC exhibited a composite outcome score that was 9.5% lower (95% CI − 15.4; − 3.5) versus those undergoing OC. LC patients experienced a 11.3% reduction in postoperative ileus (95% CI − 16.0; − 6.5) and an average of 2 days shorter length of stay (95% CI − 2.9; − 1.0). Patients undergoing LC were in the operating room an average of 13.5 min longer (95% CI 1.5; 25.6). We found no evidence for treatment heterogeneity across subgroups (p > 0.05). Patients with locally advanced colon cancer who receive LC had better overall outcomes and shorter lengths of stay compared with OC patients. LC was equally effective in obese/nonobese patients, in T4a/T4b patients, and regardless of the location of the tumor.

Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Rathin Gosavi ◽  
Clemente Chia ◽  
Michael Michael ◽  
Alexander G. Heriot ◽  
Satish K. Warrier ◽  
...  
Keyword(s):  
Systematic Review ◽  
Colon Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Advanced Colon Cancer

260. Multivisceral resections as a treatment option for locally advanced colon cancer with hepatopancreatobiliary involvement

2014 ◽  
Vol 40 (11) ◽  
pp. S105
Author(s):  
I. Shchepotin ◽  
O. Kolesnik ◽  
A. Lukashenko ◽  
D. Mahmudov ◽  
M. Volk
Keyword(s):  
Colon Cancer ◽  
Treatment Option ◽  
Locally Advanced ◽  
Advanced Colon Cancer

The Impact of a Multivisceral Resection and Adjuvant Therapy in Locally Advanced Colon Cancer

2018 ◽  
Vol 23 (2) ◽  
pp. 357-366 ◽  
Author(s):  
Lieve G. J. Leijssen ◽  
Anne M. Dinaux ◽  
R. Amri ◽  
Hiroko Kunitake ◽  
Liliana G. Bordeianou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Adjuvant Therapy ◽  
Locally Advanced ◽  
Multivisceral Resection ◽  
Advanced Colon Cancer ◽  
The Impact

scholarly journals Neoadjuvant therapy in locally advanced colon cancer: a meta-analysis and systematic review

2020 ◽  
Vol 11 (5) ◽  
pp. 847-857
Author(s):  
Chin Kai Cheong ◽  
Kameswara Rishi Yeshayahu Nistala ◽  
Cheng Han Ng ◽  
Nicholas Syn ◽  
Heidi Sian Ying Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Colon Cancer ◽  
Neoadjuvant Therapy ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Advanced Colon Cancer

FOLFOX or CAPOX perioperative chemotherapy versus postoperative chemotherapy for locally advanced colon cancer: OPTICAL study.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. TPS3637-TPS3637
Author(s):  
Yanhong Deng ◽  
Huabin Hu ◽  
Ping Lan ◽  
Lei Wang ◽  
Meijin Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Locally Advanced ◽  
Postoperative Chemotherapy ◽  
Perioperative Chemotherapy ◽  
Optical Study ◽  
Advanced Colon Cancer

Current treatment strategies and patterns of recurrence in locally advanced colon cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15171-e15171
Author(s):  
Caroline Huynh ◽  
Stephanie Minkova ◽  
Diane Kim ◽  
Heather Stuart ◽  
Trevor D Hamilton
Keyword(s):  
Colon Cancer ◽  
Locally Advanced ◽  
Positive Margin ◽  
Curative Intent ◽  
Free Survival ◽  
Node Negative ◽  
Entire Cohort ◽  
Advanced Colon Cancer ◽  
Patterns Of Recurrence

e15171 Background: Locally advanced colon cancer (LACC) is a frequent presentation and has a high rate of recurrence. The aim of this study was to evaluate current population-based strategies in LACC patients, and to analyze patterns of recurrence. Methods: We conducted a retrospective review of all patients treated at a regional cancer agency with a diagnosis of LACC between 2005 and 2015 treated with curative intent resection. Inclusion criteria were adults with T4 colon cancer, 16 cm above the anal verge, with no evidence of distant metastases. Descriptive statistics were used to define the study population. Kaplan-Meier and Cox-proportional hazards modeling were used for survival analysis. Results: 1394 patients with LACC were reviewed. Median age was 69 [IQR 60-77] and 49.3% were female. Primary tumor location was right-sided in 57.1% of cases. Most tumors were T4a (69.4%) and 39.4% were node positive. A total of 35.4% had urgent/emergent surgery, 46.4% were at least partially obstructed, 22.0% were perforated and 1.9% had a diverting ostomy as an initial operation. En-bloc multi-visceral resection occurred in 23.5% of cases. Positive margins were present in 14.3%. Only 1.6% had neoadjuvant chemotherapy and 0.8% had neoadjuvant chemoradiation. Adjuvant chemotherapy was delivered in 59.8% and adjuvant chemoradiation in 2.8%. Median follow up was 37 months. During follow up 681 (48.9%) patients died and 584 (41.9%) patients developed recurrence. In the entire cohort, rates of recurrences were local-regional (14.7%) and distant metastatic (35.1%). Overall survival for the entire cohort was 63 months [95% CI 55.7-70.3] and recurrence-free survival was 61 months [95% CI 38.8-83.2]. Multivariate analysis identified age (HR 1.03, 95% CI [1.02-1.05] p < 0.001), node negative status (HR 0.62, 95% CI [0.45-0.84] p = 0.002) and positive margin (HR 1.79, 95% CI [1.24-2.57] p = 0.002) as predictive of overall survival after adjusting for confounding factors. Predictive factors for recurrence-free survival were node negative status (HR 0.55, 95% CI [0.39-0.77] p < 0.001) and positive margin (HR 1.51, 95% CI [1.02-2.23] p = 0.038). Conclusions: Recurrence after curative intent treatment for LACC is common. Recurrence and survival patterns are significantly influenced by tumor nodal status and margin positivity.

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