scholarly journals Predictive Values of Transcutaneous Oxygen Tension for Above-the-ankle Amputation in Diabetic Patients with Critical Limb Ischemia

2007 ◽  
Vol 33 (6) ◽  
pp. 731-736 ◽  
Author(s):  
E. Faglia ◽  
G. Clerici ◽  
M. Caminiti ◽  
A. Quarantiello ◽  
V. Curci ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Diabetic Patients ◽  
Transcutaneous Oxygen Tension ◽  
Predictive Values ◽  
Transcutaneous Oxygen

scholarly journals Clinical and (31)P magnetic resonance spectroscopy characterization of patients with critical limb ischemia before and after autologous cell therapy

2019 ◽  
pp. 559-566
Author(s):  
M. Dubský ◽  
P. Šedivý ◽  
A. Němcová ◽  
M. Drobný ◽  
J. Hazdrová ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Cell Therapy ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Resonance Spectroscopy ◽  
Diabetic Patients ◽  
Transcutaneous Oxygen ◽  
Autologous Cell ◽  
Autologous Cell Therapy

Autologous cell therapy (ACT) is a new treatment method for diabetic patients with critical limb ischemia (CLI) not eligible for standard revascularization. After intramuscular injection of bone marrow-derived mononuclear cells local arteriogenesis in the ischemic tissue occurs. Studies assessing visualization of this therapeutic vasculogenesis after ACT by novel imaging techniques are lacking. The aim of our study was to assess the effect of ACT on possible metabolic changes and perfusion of critically ischemic limbs using (31)P magnetic resonance spectroscopy ((31)P MRS) and its possible correlation with changes of transcutaneous oxygen pressure (TcPO2). Twenty-one patients with diabetes and no-option CLI treated by ACT in our foot clinic over 8 years were included in the study. TcPO2 as well as rest (phosphocreatine, adenosine triphosphate and inorganic phosphate) and dynamic (mitochondrial capacity and phosphocreatine recovery time) (31)P-MRS parameters were evaluated at baseline and 3 months after cell treatment. TcPO2 increased significantly after 3 months compared with baseline (from 22.4±8.2 to 37.6±13.3 mm Hg, p=0.0002). Rest and dynamic (31)P MRS parameters were not significantly different after ACT in comparison with baseline values. Our study showed a significant increase of TcPO2 on the dorsum of the foot after ACT. We did not observe any changes of rest or dynamic (31)P MRS parameters in the area of the proximal calf where the cell suspension has been injected into.

scholarly journals Perfusion Scintigraphy in the Assessment of Autologous Cell Therapy in Diabetic Patients With Critical Limb Ischemia

2018 ◽  
pp. 583-589 ◽  
Author(s):  
A. NEMCOVA ◽  
A. JIRKOVSKA ◽  
M. DUBSKY ◽  
R. BEM ◽  
V. FEJFAROVA ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Diabetic Patients ◽  
Perfusion Scintigraphy ◽  
Transcutaneous Oxygen ◽  
Autologous Cell ◽  
Autologous Cell Therapy ◽  
99Mtc Mibi ◽  
Calf Muscles

Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile (99mTc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether 99mTc-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. 99mTc-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI. Scintigraphic parameters such as rest count and exercising count after a stress test were defined. These parameters and their ratios were compared between treated and untreated (control) limbs and with changes in transcutaneous oxygen pressure (TcPO2) that served as a reference method. The effect of ACT was confirmed by a significant increase in TcPO2 values (p˂0.001) at 3 months after ACT. We did not observe any significant changes of scintigraphic parameters both at rest and after stress 3 months after ACT, there were no differences between treated and control limbs and no association with TcPO2 changes. Results of our study showed no significant contribution of 99mTc-MIBI of calf muscles to the assessment of ACT in diabetic patients with CLI over a 3-month follow-up period.

Transcutaneous Oxygen Tension in Legs and Feet of Diabetic Patients

Diabetes ◽  
1988 ◽  
Vol 37 (6) ◽  
pp. 714-716 ◽  
Author(s):  
P. M. Gaylarde ◽  
V. A. Fonseca ◽  
G. Llewellyn ◽  
I. Sarkany ◽  
P. K. Thomas ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Diabetic Patients ◽  
Transcutaneous Oxygen Tension ◽  
Transcutaneous Oxygen

scholarly journals Arterial diseases of lower extremities in diabetic patients: current state and prospects of therapy

2011 ◽  
Vol 14 (1) ◽  
pp. 74-80
Author(s):  
Gagik Radikovich Galstyan ◽  
Alla Yur'evna Tokmakova ◽  
Olga Nikolaevna Bondarenko ◽  
Ivan Ivanovich Sitkin ◽  
Kira Yur'evna Pryakhina ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Critical Limb Ischemia ◽  
Lower Extremities ◽  
Limb Ischemia ◽  
Diabetic Patients ◽  
Special Importance ◽  
Transcutaneous Oxygen ◽  
Current State ◽  
Patients At Risk ◽  
Peripheral Artery Diseases

Peripheral artery diseases (PAD) are most serious diabetic complications responsible for the high risk of amputation of lower extremities. The occurrenceof PAD in diabetic patients is much higher than in subjects with undisturbed carbohydrate metabolism. PAD in diabetic patients is frequentlyan asymptomatic condition affecting distal portions of arterial segments and associated with pronounced mediacalcinosis. Standard diagnostic proceduresfor the screening of arterial lesions must be supplemented by non-invasive visualization and measurement of transcutaneous oxygen tensionin patients at risk of PAD and persisting foot ulcers. Of special importance is early diagnosis of critical limb ischemia and prevention of foot lesions.Combined treatment of diabetic foot syndrome in patients with critical limb ischemia includes normalization of foot circulation, surgical interventionand conservative therapy of the wound, monitoring concomitant micro- and macrovascular diabetic complications?

Transcutaneous oxygen tension in legs and feet of diabetic patients

Diabetes ◽  
1988 ◽  
Vol 37 (6) ◽  
pp. 714-716 ◽  
Author(s):  
P. M. Gaylarde ◽  
V. A. Fonseca ◽  
G. Llewellyn ◽  
I. Sarkany ◽  
P. K. Thomas ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Diabetic Patients ◽  
Transcutaneous Oxygen Tension ◽  
Transcutaneous Oxygen
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