The beginnings and progress in implementing sustainable development in different areas with large impacts on the environment, society, and economy in the last decade is summarized. Thus, the different existing approaches and possible future developments for applying the sustainability concept are analyzed, starting with municipalities and urban planning but also including the applications to engineering projects and companies in the recent search for global sustainable development. An analysis is developed of the weaknesses and strengths in existing proposals for assessing sustainability and the consideration of the basis for sustainable development in all sustainability assessment applications is proposed. Through this approach, from the lessons learned in previous experiences, a framework to manage and to create sustainability assessment models is proposed, including standard procedures, allowing trend settings to designers, the government, developers, and decision-making centers. Key performance indicators are being widely used in such applications, becoming the sustainability assessment tool of any project or activity. The ultimate aim of this chapter is to enhance the awareness of all stakeholders in the need for a more sustainable global development, considering actions not only in the immediate environment but also in indirect environments in space and time.