Global sensitivity analysis of lateral-torsional buckling resistance based on finite element simulations

2017 ◽  
Vol 134 ◽  
pp. 37-47 ◽  
Author(s):  
Zdeněk Kala ◽  
Jan Valeš
Keyword(s):  
Sensitivity Analysis ◽  
Finite Element ◽  
Global Sensitivity Analysis ◽  
Finite Element Simulations ◽  
Lateral Torsional Buckling ◽  
Torsional Buckling ◽  
Global Sensitivity ◽  
Buckling Resistance

scholarly journals On the Resistance Evaluation of Lateral-torsional Buckling of Bisymmetrical I-section Beams Using Finite Element Simulations

2016 ◽  
Vol 153 ◽  
pp. 180-188 ◽  
Author(s):  
Marian Giżejowski ◽  
Radosław Szczerba ◽  
Marcin Gajewski ◽  
Zbigniew Stachura
Keyword(s):  
Finite Element ◽  
Finite Element Simulations ◽  
Lateral Torsional Buckling ◽  
Torsional Buckling ◽  
Resistance Evaluation

scholarly journals Phototransduction in retinal cones: Analysis of parameter importance

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258721
Author(s):  
Colin Klaus ◽  
Giovanni Caruso ◽  
Vsevolod V. Gurevich ◽  
Heidi E. Hamm ◽  
Clint L. Makino ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Finite Element ◽  
Dark Current ◽  
Turnover Rate ◽  
Global Sensitivity Analysis ◽  
Element Model ◽  
Hydrolysis Rate ◽  
Global Sensitivity ◽  
Activation Rate ◽  
Flash Response

In daylight, cone photoreceptors in the retina are responsible for the bulk of visual perception, yet compared to rods, far less is known quantitatively about their biochemistry. This is partly because it is hard to isolate and purify cone proteins. The issue is also complicated by the synergistic interaction of these parameters in producing systems biology outputs, such as photoresponse. Using a 3-D resolved, finite element model of cone outer segments, here we conducted a study of parameter significance using global sensitivity analysis, by Sobol indices, which was contextualized within the uncertainty surrounding these parameters in the available literature. The analysis showed that a subset of the parameters influencing the circulating dark current, such as the turnover rate of cGMP in the dark, may be most influential for variance with experimental flash response, while the shut-off rates of photoexcited rhodopsin and phosphodiesterase also exerted sizable effect. The activation rate of transducin by rhodopsin and the light-induced hydrolysis rate of cGMP exerted measurable effects as well but were estimated as relatively less significant. The results of this study depend on experimental ranges currently described in the literature and should be revised as these become better established. To that end, these findings may be used to prioritize parameters for measurement in future investigations.

Sign in / Sign up

Export Citation Format

Share Document