Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A

2016 ◽  
Vol 86 ◽  
pp. 52-59 ◽  
Author(s):  
Glenn Gauderat ◽  
Nicole Picard-Hagen ◽  
Pierre-Louis Toutain ◽  
Tanguy Corbel ◽  
Catherine Viguié ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Fetal Exposure ◽  
Determining Factor

373 BIOLOGICAL EFFECTS OF FETAL EXPOSURE TO BISPHENOL A ON UROGENITAL SINUS

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Kenichiro Ishii ◽  
Shigeki Arase ◽  
Yuko Yoshio ◽  
Katsuhide Igarashi ◽  
Kenichi Aisaki ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Biological Effects ◽  
Urogenital Sinus ◽  
Fetal Exposure

scholarly journals DNA oxidation induced by fetal exposure to BPA agonists impairs female meiosis

2020 ◽  
Author(s):  
Sonia Abdallah ◽  
Delphine Moison ◽  
Margaux Wieckowski ◽  
Sébastien Messiaen ◽  
Emmanuelle Martini ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptors ◽  
In Utero ◽  
Dna Oxidation ◽  
Common Mechanism ◽  
Fetal Exposure ◽  
Female Meiosis ◽  
Dna Damages ◽  
Germ Cell Differentiation ◽  
Bpa Analogs

SummaryMany endocrine disruptors have been proven to impair the meiotic process that is mandatory to produce healthy gametes. Bisphenol A is emblematic as it impairs meiotic prophase I and causes oocyte aneuploidy following in utero exposure. However, the mechanisms underlying these deleterious effects remain poorly understood. Furthermore, the increasing uses of BPA analogs raise concerns for public health. Here, we investigated the effect on oogenesis in mouse of fetal exposure to two BPA analogs, Bisphenol A Diglycidyl Ether (BADGE) or Bisphenol AF (BPAF). These analogs delay meiosis initiation, increase MLH1 foci per cell and induce oocyte aneuploidy. We further demonstrate that these defects are accompanied by a deregulation of gene expression and aberrant mRNA splicing in fetal premeiotic germ cells. Interestingly, we observed an increase in DNA oxidation after exposure to BPA analogs. Specific induction of oxidative DNA damages during fetal germ cell differentiation causes similar defects during oogenesis, as observed in 8-Oxoguanine DNA Glycosylase (OGG1) deficient mice or after in utero exposure to potassium bromate (KBrO3), an inducer of oxidative DNA damages. Moreover, the supplementation of N-acetylcysteine (NAC) with BPA analogs counteracts the bisphenol-induced meiotic effect. Together our results position oxidative stress as a central event that negatively impacts the female meiosis with major consequences on oocyte quality. This could be a common mechanism of action for so called endocrine disruptors pollutants and it could lead to novel strategies for reprotoxic compounds.

scholarly journals Long-Term Effects of Fetal Exposure to Low Doses of the Xenoestrogen Bisphenol-A in the Female Mouse Genital Tract1

2005 ◽  
Vol 72 (6) ◽  
pp. 1344-1351 ◽  
Author(s):  
Caroline M. Markey ◽  
Perinaaz R. Wadia ◽  
Beverly S. Rubin ◽  
Carlos Sonnenschein ◽  
Ana M. Soto
Keyword(s):  
Bisphenol A ◽  
Female Mouse ◽  
Low Doses ◽  
Fetal Exposure ◽  
Long Term Effects

THE UNIQUE PHARMACOKINETIC CHARACETERISTICS OF BISPHENOL A IN AMNIOTIC FLUID: THE IMPLICATION OF FETAL EXPOSURE

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Chensheng (Alex) Lu ◽  
Andrea Edlow ◽  
Nicole Smith ◽  
Mei Chen ◽  
Thomas McElrath
Keyword(s):  
Bisphenol A ◽  
Amniotic Fluid ◽  
Fetal Exposure

Conjugation and Deconjugation Reactions within the Fetoplacental Compartment in a Sheep Model: A Key Factor Determining Bisphenol A Fetal Exposure

2015 ◽  
Vol 43 (4) ◽  
pp. 467-476 ◽  
Author(s):  
Tanguy Corbel ◽  
Elisabeth Perdu ◽  
Véronique Gayrard ◽  
Sylvie Puel ◽  
Marlène Z. Lacroix ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Fetal Exposure ◽  
Sheep Model ◽  
Key Factor

Fetal Exposure To Bisphenol A Disrupts Lung Development

2012 ◽  
Author(s):  
Laura S. Van Winkle ◽  
Shannon Murphy ◽  
Miriam Boetticher ◽  
Catherine VandeVoort
Keyword(s):  
Bisphenol A ◽  
Lung Development ◽  
Fetal Exposure
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