Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A.

In the rat, testosterone (T) in the neonatal period plays an important role in sexual differentiation and there is a serum T surge in male rats 2 hours after birth. Pregnant female rats were exposed to various doses of bisphenol A (BPA) from gestational day 1 (GD1) through 2 hours after parturition. About half of the BPA-exposed and control dams were subjected to cesarean section on GD22. The male fetuses on GD22 were immediately sacrificed and blood was collected. The other half of the BPA-treated and control dams delivered at GD23 (parturition day). The male pups were sacrificed 2 hours after birth. Serum T concentration was determined by radioimmunoassay (RIA). The BPA concentration in the fetal serum on GD22 increased inversely to the T levels in the serum. The T concentration in the pups' serum 2 hours after birth decreased inversely to the BPA concentration in the serum. However, there were no differences in the serum T concentration among the various doses of BPA. These results suggest that exposure to BPA in utero inhibits the T surge in the neonatal period and we speculate that exposure to BPA in utero disrupts the endocrine environment in the neonatal male.

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Social Dominance and Serum Testosterone Concentration in Dyads of Male Macaca fascicularis

Journal of Medical Primatology ◽

10.1111/j.1600-0684.1986.tb00306.x ◽

1986 ◽

Vol 15 (6) ◽

pp. 419-432 ◽

Cited By ~ 1

Author(s):

Margaret R. Clarke ◽

Jay R. Kaplan ◽

Patricia T. Bumsted ◽

Donald R. Koritnik

Keyword(s):

Social Dominance ◽

Macaca Fascicularis ◽

Serum Testosterone ◽

Testosterone Concentration

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The effect of cyproterone acetate on serum lipids in normal men

Acta Endocrinologica ◽

10.1530/acta.0.0940280 ◽

1980 ◽

Vol 94 (2) ◽

pp. 280-283 ◽

Cited By ~ 6

Author(s):

Finn Damgaard-Pedersen ◽

Marie Føgh

Keyword(s):

Cyproterone Acetate ◽

Serum Lipids ◽

Ldl Cholesterol ◽

Serum Testosterone ◽

Tolerance Test ◽

Low Doses ◽

Testosterone Concentration ◽

Fat Tolerance Test ◽

Normal Men ◽

Atherosclerotic Risk Factors

Abstract. In a male anti-fertility study 7 volunteers received the anti-androgen cyproterone acetate (5 or 10 mg daily) orally in a paired study. A significant reduction in serum-cholesterol and LDL-cholesterol, and a significant increase in the intravenous-fat-tolerance-test (IVFTT) was observed. Thus low doses of cyproterone acetate reduced the serum testosterone concentration and some of the atherosclerotic risk factors.

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Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice

PLoS ONE ◽

10.1371/journal.pone.0208846 ◽

2018 ◽

Vol 13 (12) ◽

pp. e0208846 ◽

Cited By ~ 2

Author(s):

Julia A. Taylor ◽

Jennifer M. Sommerfeld-Sager ◽

Chun-Xia Meng ◽

Susan C. Nagel ◽

Toshi Shioda ◽

...

Keyword(s):

Growth Rate ◽

Body Weight ◽

Glucose Tolerance ◽

Bisphenol A ◽

Serum Concentrations ◽

Male Mice ◽

Impair Glucose Tolerance ◽

Reduced Body ◽

Fetal Serum

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Testosterone level, nasal gland volume and Leydig cell morphometry in capybaras (Hydrochoerus hydrochaeris)

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/s0102-09352006000600017 ◽

2006 ◽

Vol 58 (6) ◽

pp. 1086-1091 ◽

Cited By ~ 14

Author(s):

D.S. Costa ◽

T.A.R. Paula

Keyword(s):

Cell Volume ◽

Leydig Cell ◽

Gonadosomatic Index ◽

Serum Testosterone ◽

Volume Density ◽

Testosterone Concentration ◽

Gland Volume ◽

Testicular Weight ◽

Hydrochoerus Hydrochaeris ◽

Proportional Increase

The testosterone levels with nasal gland volume and Leydig cell morphometry in sexually mature capybaras were compared using 10 adult capybaras, aging 28 months. Body and testicular weight were 50kg and 28g, respectively. The gonadosomatic index was 0.11±0.02%, while nasal gland volume was 34.12±13.04ml. Serum testosterone concentration was 25.07±14.73ng/ml. Leydig cell volume density and leydigosomatic index were, respectively, 28.8±8.3% and 0.030±0.007%. Total and individual Leydig cell volumes were 6.88±1.92ml and 2,228.14±272.59x10-12ml, respectively. Leydig cell numbers per testis and per gram of testis were, respectively, 3,079.4±719.9x10(6) and 115.09±31.78x10(6) cells. These results show that increase in serum testosterone concentration is correlated to a proportional increase of nasal gland and Leydig cell volume in capybaras.

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