scholarly journals The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood–brain barrier: A positron emission tomography study

2012 ◽  
Vol 100 (1-2) ◽  
pp. 93-103 ◽  
Author(s):  
Severin Mairinger ◽  
Jens P. Bankstahl ◽  
Claudia Kuntner ◽  
Kerstin Römermann ◽  
Marion Bankstahl ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Multidrug Resistance ◽  
Antiepileptic Drug ◽  
Blood Brain Barrier ◽  
Emission Tomography ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 1 ◽  
P Glycoprotein ◽  
Positron Emission ◽  
Resistance Protein

scholarly journals Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

2015 ◽  
Vol 35 (5) ◽  
pp. 743-746 ◽  
Author(s):  
Martin Bauer ◽  
Rudolf Karch ◽  
Markus Zeitlinger ◽  
Cécile Philippe ◽  
Kerstin Römermann ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Brain Barrier ◽  
Distribution Volume ◽  
Emission Tomography ◽  
Brain Barrier ◽  
Whole Brain ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Positron Emission ◽  
Pet Scans

As P-glycoprotein (Pgp) inhibition at the blood–brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron emission tomography (PET) scans with the Pgp substrate ( R)-[11C]verapamil in five healthy volunteers during continuous intravenous tariquidar infusion. Total distribution volume ( VT) of ( R)-[11C]verapamil in whole-brain gray matter increased by 273 ± 78% relative to baseline scans without tariquidar, which was higher than previously reported VT increases. During tariquidar infusion whole-brain VT was comparable to VT in the pituitary gland, a region not protected by the BBB, which suggested that we were approaching complete Pgp inhibition at the human BBB.

P-glycoprotein at the Blood-Brain Barrier and Analysis of Drug Transport with Positron-Emission Tomography

2001 ◽  
Vol 41 (7) ◽  
pp. 48-54 ◽  
Author(s):  
N. H. Hendrikse ◽  
J. Bart ◽  
E.G.E. de Vries ◽  
H.J.M. Groen ◽  
W.T.A. van der Graaf ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Brain Barrier ◽  
Drug Transport ◽  
Emission Tomography ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Positron Emission

scholarly journals Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography

2015 ◽  
Vol 12 (9) ◽  
pp. 3214-3225 ◽  
Author(s):  
Thomas Wanek ◽  
Kerstin Römermann ◽  
Severin Mairinger ◽  
Johann Stanek ◽  
Michael Sauberer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Drug Interactions ◽  
Blood Brain Barrier ◽  
Emission Tomography ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Positron Emission

P-glycoprotein at the Blood-Brain Barrier and Analysis of Drug Transport with Positron-Emission Tomography

2001 ◽  
Vol 41 (99) ◽  
pp. 48-54 ◽  
Author(s):  
N.H. Hendrikse ◽  
J. Bart ◽  
E.G.E. de Vries ◽  
H.J.M. Groen ◽  
W.T.A. van der Graaf ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Brain Barrier ◽  
Drug Transport ◽  
Emission Tomography ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Positron Emission
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