AACE2021-A-1055: Efficacy of Umbilical Cord Blood-Derived Stem Cells Transplantation Versus Their Conditioned Media in Hypothyroid Rats on Thyroid Function and Structure

2021 ◽  
Vol 27 (12) ◽  
pp. S31-S32
Author(s):  
Maged Hossameldin ◽  
Mohamed Reda Halawa ◽  
Laila Mahmoud Hindawy ◽  
Asmaa Abdelmoanem Abozeid ◽  
Dina Ahmed Marawan
Keyword(s):  
Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Thyroid Function ◽  
Umbilical Cord Blood ◽  
Conditioned Media ◽  
Stem Cells Transplantation

scholarly journals Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes

Blood ◽  
2006 ◽  
Vol 108 (10) ◽  
pp. 3360-3362 ◽  
Author(s):  
Karen M. Pastos ◽  
William B. Slayton ◽  
Lisa M. Rimsza ◽  
Linda Young ◽  
Martha C. Sola-Visner
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Peripheral Blood ◽  
Conditioned Media ◽  
Valuable Source ◽  
Cd34 Cells ◽  
Adult Bone

Abstract Umbilical cord blood (CB) is a valuable source of stem cells for transplantation, but CB transplantations are frequently complicated by delayed platelet engraftment. The reasons underlying this are unclear. We hypothesized that CB- and peripheral-blood (PB)–derived megakaryocytes (MKs) respond differently to the adult hematopoietic microenvironment and to thrombopoietin (Tpo). To test this, we cultured CB- and PB-CD34+ cells in adult bone marrow stromal conditioned media (CM) or unconditioned media (UCM) with increasing concentrations of recombinant Tpo and compared the effects of these conditions on CB-versus PB-MKs. PB-MKs reached highest ploidy in response to UCM + 100 ng/mL rTpo, and the addition of CM inhibited their maturation. In contrast, CB-MKs reached highest ploidy in CM without rTpo, and high rTpo concentrations (> 0.1 ng/mL) inhibited their maturation. This is the first evidence that human neonatal and adult MKs have substantially different biologic responses to Tpo and potentially to other cytokines.

scholarly journals Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Huiping Li ◽  
Fang Yuan ◽  
Yaming Du ◽  
Tao Pan ◽  
Wanxin Wen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cord Blood ◽  
Progressive Supranuclear Palsy ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Alternative Therapy ◽  
Muscle Rigidity ◽  
Blood Stem Cells ◽  
Cord Blood Stem Cells ◽  
Stem Cells Transplantation

Abstract Background Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. Case presentation We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years. Conclusions Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy.

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