Numerical optimization and inverse study of a microfluidic device for blood plasma separation

2016 ◽  
Vol 57 ◽  
pp. 31-39 ◽  
Author(s):  
Amir Shamloo ◽  
Parham Vatankhah ◽  
Mohamad Ali Bijarchi
2019 ◽  
Vol 209 ◽  
pp. 28-34 ◽  
Author(s):  
L. Spigarelli ◽  
V. Bertana ◽  
D. Marchisio ◽  
L. Scaltrito ◽  
S. Ferrero ◽  
...  

Lab on a Chip ◽  
2016 ◽  
Vol 16 (8) ◽  
pp. 1492-1504 ◽  
Author(s):  
Mokhamad Fakhrul Ulum ◽  
Leni Maylina ◽  
Deni Noviana ◽  
Dedy Hermawan Bagus Wicaksono

Whole blood plasma separation and assay using EDTA-treated cotton thread.


Lab on a Chip ◽  
2010 ◽  
Vol 10 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Angeles Ivón Rodríguez-Villarreal ◽  
Martin Arundell ◽  
Manuel Carmona ◽  
Josep Samitier

Author(s):  
Sung Yang ◽  
Akif U¨ndar ◽  
Jeffrey D. Zahn

A microfluidic device for continuous, real time blood plasma separation is introduced. This device is composed of a blood inlet, a purified plasma outlet, and a concentrated blood cell outlet. It is designed to separate blood plasma from an initial blood sample of up to 45 % hematocrit (Hct). The microfluidic device is designed and analyzed using an analogous electrical circuit, analytical and numerical studies. The numerical study results show that 27 % and 25 % of plasma volume can be separated from a total inlet blood volume of 45 % and 39 % hematocrit, respectively. The functionality of this device was demonstrated using defibrinated sheep blood (Hct=36 %). During 2 hrs. of continuous blood infusion through the device, all the blood cells traveled through the device toward the concentrated blood outlet while only the plasma flowed towards the plasma outlet without any clogging or lysis of cells. The experimentally measured plasma skimming volume was about 33 % for a 36 % inlet hematocrit. Due to the device’s simple structure and control mechanism, this microdevice is expected to be used for highly efficient continuous, real time cell-free blood plasma separation device.


Lab on a Chip ◽  
2006 ◽  
Vol 6 (7) ◽  
pp. 871-880 ◽  
Author(s):  
Sung Yang ◽  
Akif Ündar ◽  
Jeffrey D. Zahn

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