HIGH FREQUENCY DEEP REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (dTMS) OF MEDIAL PREFRONTAL AND ANTERIOR CINGULATE CORTICES IN PATIENTS WITH OCD: A DOUBLE-BLIND, PLACEBO CONTROLLED, PERSPECTIVE MULTI-CENTER STUDY

2018 ◽  
Vol 28 (6) ◽  
pp. 777-778
Author(s):  
Lior Carmi ◽  
Aron Tendler ◽  
Joseph Zoher ◽  
Abraham Zangen
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Anterior Cingulate ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Multi Center Study ◽  
Center Study

Neurostimulation in alcohol dependence: The effect of repetitive transcranial magnetic stimulation on brain function and craving

2016 ◽  
Vol 33 (S1) ◽  
pp. S59-S59
Author(s):  
J. Jansen ◽  
O. van den Heuvel ◽  
Y. van der Werf ◽  
S. De Wit ◽  
D. Veltman ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Transcranial Magnetic Stimulation ◽  
Alcohol Dependence ◽  
Neural Activity ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Negative Emotion ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Anterior Cingulate ◽  
Fmri Session

BackgroundAlcohol dependence has long been related to impaired processing and handling of negative emotions. This is the first study to compare emotion regulation (ER) at a behavioral and neural level in alcohol dependent patients (ADPs) and healthy controls (HCs). It also examines the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on ER abilities and related craving levels in ADPs.MethodThirty-six ADPs and 32 HCs matched on age, sex, and education, were included in a within-subject fixed-order study with one functional magnetic resonance imaging (fMRI) session and one rTMS plus fMRI session, with high-frequency (10 Hz) rTMS over the right dorsolateral prefrontal cortex (dlPFC). An fMRI emotion regulation task (ERT) was administered during both sessions and craving was measured before and after each ERT.ResultsADPs were impaired in the regulation of negative emotion and showed a higher activation of ER related brain areas compared to HCs. Furthermore, active rTMS improved ER abilities in both ADPs and HCs, but was accompanied by a decrease in anterior cingulate and left dlPFC activity only in ADPs. In addition, the ERT-induced increase in craving levels in ADPs was trend-significantly reduced by active rTMS, with a large effect size.ConclusionsADPs are impaired in the regulation of negative emotion and show enhanced neural activity in the ER brain circuit. High-frequency rTMS improves ER in ADPs and HCs and normalizes neural activity and tends to reduce craving in ADPs. Future studies are needed to test the long-term effects of (multiple session) rTMS on ER, craving, and drinking.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine

Cephalalgia ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 464-472 ◽  
Author(s):  
Adriana B Conforto ◽  
Edson Amaro ◽  
André L Gonçalves ◽  
Juliane PP Mercante ◽  
Vera Z Guendler ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Transcranial Magnetic Stimulation ◽  
Chronic Migraine ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Sham Group ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Response ◽  
Double Blind ◽  
Proof Of Principle

Background High-frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex (rTMS-DLPFC) is an effective treatment for depression. Preliminary studies indicated beneficial effects of rTMS-DLPFC on pain relief in patients treated for depression, and in patients with chronic migraine. Methods In this randomized, double-blind, parallel-group, single-center, proof-of-principle clinical trial, we tested the hypothesis that 23 sessions of active rTMS-DLPFC delivered over eight weeks would be feasible, safe and superior to sham rTMS to decrease the number of headache days in 18 patients with chronic migraine without severe depression. Per-protocol analysis was performed. Results rTMS-DLPFC applied over eight weeks was feasible and safe in patients with chronic migraine. Contrary to our primary hypothesis, the number of headache days decreased significantly more in the sham group than in the group treated with active rTMS-DLPFC at eight weeks. Average decrease in headache days was >50% in the sham group, indicating a powerful placebo response. Pain intensity improved in both groups to a similar extent. Conclusions Positive results of M1 stimulation in other studies, and the absence of significant benefits of active high-frequency rTMS of the DLPFC in the present study, point to M1 as a more promising target than the DLPFC, for larger trials of noninvasive brain stimulation in patients with chronic migraine.

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