M61 VALIDATION, CHARACTERIZATION OF OBSESSIVE-COMPULSIVE DISORDER CASE SAMPLES IDENTIFIED IN LARGE US BIOBANK

2019 ◽  
Vol 29 ◽  
pp. S199
Author(s):  
Takahiro Soda ◽  
James Crowley ◽  
Evonne McArthur ◽  
Patrick McGuire ◽  
Julia Sealock ◽  
...  

The present text carries out a characterization of the anomalous functioning of cognitive and emotional processes governed by the guidelines of a central dysexecutive control, modulated by persistent, negligent, and sometimes insensitive patterns to command lines of detection of external stimuli and required adjustment of focus according to changing keys of a demanding task-oriented context. Rumination as a metacognitive process, once anarchic, is in a domain-free domain capable of usurping memory and attentional resources by retrieving them to the self-referential self, making it a preferred focus of relevance. The ruminative process, slipping into the conscious network normally alert, is incessantly overwritten until it colonizes it, makes it neglect its tasks of observation and surveillance, to instead, abstract it from the outside world and overturn it in a kind of inflated self-absorption or hyper-augmented self-consciousness. The cognitive rumination is postulated as the polymorphic process that serves as a base substrate to explain the logic of appearance and maintenance of both obsessive-compulsive disorder and major depression, these diagnostic entities being the expression of the same polymorphic process. Turned to the future in the TOC and to the past in the TDM. Finally, a review is made of the evidence that the practice of mindfulness has reported in reducing rumination.


PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e70376 ◽  
Author(s):  
Uzoezi Ozomaro ◽  
Guiqing Cai ◽  
Yuji Kajiwara ◽  
Seungtai Yoon ◽  
Vladimir Makarov ◽  
...  

2011 ◽  
Vol 69 (4) ◽  
pp. 642-647 ◽  
Author(s):  
Felipe Filardi da Rocha ◽  
Nathália Bueno Alvarenga ◽  
Leandro Malloy-Diniz ◽  
Humberto Corrêa

OBJECTIVE: This study aims to evaluate the process of decision-making in patients with obsessive-compulsive disorder (OCD) using the Iowa Gambling Task (IGT). In addition, we intend to expand the understanding of clinical and demographic characteristics that influence decision-making. METHOD: Our sample consisted of 214 subjects (107 diagnosed with OCD and 107 healthy controls) who were evaluated on their clinical, demographic and neuropsychological features. Moreover, the Iowa Gambling Task (IGT), a task that detects and measures decision-making impairments, was used. RESULTS: We found that OCD patients performed significantly worse on the IGT. Furthermore, features such as symptoms of anxiety did not influence IGT performance. CONCLUSION: Impaired decision-making seems to be a key feature of OCD. Given that OCD is a complex heterogeneous disorder, homogeneous groups are necessary for an accurate characterization of our findings.


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