P.610 Clustering patients by depression symptoms may predict treatment outcomes for major depressive disorder: Patient-level meta-analysis of venlafaxine extended release trials

AbstractAcupuncture is an important alternative therapy in treating major depressive disorder (MDD), but its efficacy and safety are still not well assessed. This study is the first network meta-analysis exploring the effectiveness and safety of acupuncture, common pharmacological treatments or other non-medication therapies for MDD. Eight databases including PubMed, Embase, Allied and Complementary Medicine Database, Cochrane Library, Wan Fang Data, China National Knowledge Infrastructure, China Biology Medicine disc, and Chongqing VIP Database were searched up to Jan 17, 2021. Articles were screened and selected by two reviewers independently. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess the certainty of the evidence. A total of 71 eligible studies were included. The network analysis results indicated that the combined interventions of electro-acupuncture (EA) with selective serotonin reuptake inhibitors (SSRIs) and manual acupuncture (MA) with SSRIs were more effective in improving depression symptoms compared with acupuncture alone, pharmacological interventions alone, or other inactive groups. Among all the regimens, EA with SSRIs was found to have the highest effect in improving depression symptoms of MDD. In addition, there were slight differences in the estimations of the various treatment durations. The combination of acupuncture and serotonin-norepinephrine reuptake inhibitors (SNRIs) was found to be more effective than SNRIs alone. In conclusion, acupuncture and its combinations could be safe and effective interventions for MDD patients. EA with SSRIs seems to be the most effective intervention among the assessed interventions. Well-designed and large-scale studies with long-term follow-up should be conducted in the future.

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Treatment Outcomes in a Partial Hospital Program for Patients with Social Anxiety Disorder: The Effects of Comorbid Major Depression

American Journal of Undergraduate Research ◽

10.33697/ajur.2020.033 ◽

2021 ◽

Vol 17 (4) ◽

pp. 33-40

Author(s):

Allison Graham ◽

Douglas Terrill ◽

Simone Boyd ◽

Isabel Benjamin ◽

Madeline Ward ◽

...

Keyword(s):

Major Depressive Disorder ◽

Anxiety Disorder ◽

Social Anxiety ◽

Depressive Disorder ◽

Treatment Outcomes ◽

Social Anxiety Disorder ◽

Post Treatment ◽

Depression Symptoms ◽

Partial Hospitalization ◽

Major Depressive

Although previous studies have examined the impact of comorbid major depressive disorder (MDD) on social anxiety disorder (SAD), the results have been somewhat mixed. Furthermore, most studies have been conducted in inpatient or outpatient settings. Given the large body of literature that suggests that this particular comorbidity can have negative effects on treatment efficacy and outcomes, it is important to continue to explore its impact. The present study aims to clarify contradictions in the literature and expands on previous studies by examining patients in a partial hospitalization setting. Patients at Rhode Island Hospital with a diagnosis of SAD were compared to those with comorbid SAD and MDD on pre-treatment and post-treatment measures of anxiety and depression. The results indicated that while the comorbid group showed significantly less improvement post-treatment on anxiety symptoms and constructs related to remission from depression, they did not show significantly less improvement on depression symptoms. The implications of these results for clinical practice are discussed. KEYWORDS: Social Anxiety Disorder; Major Depressive Disorder; Comorbid Anxiety Disorders; Comorbid Mood Disorders; Treatment Outcomes; Partial Hospitalization Program

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Major Depressive Disorder Patient Reported Outcome Measure

PsycTESTS Dataset ◽

10.1037/t41501-000 ◽

2012 ◽

Author(s):

Kathryn Eilene Lasch ◽

Mariam Hassan ◽

Jean Endicott ◽

Elisabeth Carine Piault-Luis ◽

Julie Locklear ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Outcome Measure ◽

Patient Reported Outcome ◽

Major Depressive Disorder Patient ◽

Major Depressive ◽

Patient Reported Outcome Measure ◽

Patient Reported ◽

Disorder Patient

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T32ALTERED SEROTONERGIC NEUROTRANSMISSION IN SELECTIVE SEROTONIN REUPTAKE INHIBITOR-RESISTANT MAJOR DEPRESSIVE DISORDER PATIENT DERIVED NEURONS

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2019.08.231 ◽

2019 ◽

Vol 29 ◽

pp. S234

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Major Depressive Disorder Patient ◽

Serotonin Reuptake Inhibitor ◽

Major Depressive ◽

Disorder Patient

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Qigong-Based Therapy for Treating Adults with Major Depressive Disorder: A Meta-Analysis of Randomized Controlled Trials

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16050826 ◽

2019 ◽

Vol 16 (5) ◽

pp. 826 ◽

Cited By ~ 4

Author(s):

Lijuan Guo ◽

Zhaowei Kong ◽

Yanjie Zhang

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Cochrane Library ◽

Depression Symptoms ◽

Controlled Trials ◽

Control Groups ◽

Major Depressive ◽

Randomized Controlled

This current meta-analysis review was conducted to examine the effectiveness of Qigong-based therapy on individuals with major depressive disorder. Six electronic databases (PubMed, PsycINFO, Cochrane Library, and Web of Science, Chinese National Knowledge Infrastructure, and Wangfang) were employed to retrieve potential articles that were randomized controlled trials. The synthesized effect sizes (Hedges’ g) were computerized to explore the effectiveness of Qigong-based therapy. Additionally, a moderator analysis was performed based on the control type. The pooled results indicated that Qigong-based therapy has a significant benefit on depression severity (Hedges’ g = −0.64, 95% CI −0.92 to −0.35, p < 0. 001, I2 = 41.73%). Specifically, Qigong led to significantly reduced depression as compared to the active control groups (Hedges’ g = −0.47, 95% CI −0.81 to −0.12, p = 0.01, I2 = 22.75%) and the passive control groups (Hedges’ g = −0.80, 95% CI −1.23 to −0.37, p < 0.01, I2 = 48.07%), respectively. For studies which reported categorical outcomes, Qigong intervention showed significantly improved treatment response rates (OR = 4.38, 95% CI 1.26 to 15.23, p = 0.02) and remission rates (OR = 8.52, 95% CI 1.91 to 37.98, p = 0.005) in comparison to the waitlist control group. Conclusions: Qigong-based exercises may be effective for alleviating depression symptoms in individuals with major depressive disorder. Future well-designed, randomized, controlled trials with large sample sizes are needed to confirm these findings.

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