Synthesis and characterization of hydrophobically modified polyacrylamides and some observations on rheological properties

2004 ◽  
Vol 40 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Wei Xue ◽  
Ian W Hamley ◽  
Valeria Castelletto ◽  
Peter D Olmsted
1998 ◽  
Vol 31 (20) ◽  
pp. 7099-7102 ◽  
Author(s):  
Megan Spafford ◽  
Alla Polozova ◽  
Françoise M. Winnik

2001 ◽  
Vol 12 (11-12) ◽  
pp. 616-625 ◽  
Author(s):  
Dong-qing Zhuang ◽  
Jie Chen Ai-hua Da ◽  
Yun-xiang Zhang ◽  
Reinhold Dieing ◽  
Lian Ma ◽  
...  

2012 ◽  
Vol 88 (3) ◽  
pp. 1015-1022 ◽  
Author(s):  
Honghong Gong ◽  
Mingzhu Liu ◽  
Jiucun Chen ◽  
Fei Han ◽  
Chunmei Gao ◽  
...  

Author(s):  
Alexey Shakhvorostov ◽  
Zhanar Nurakhmetova ◽  
Gulnur Tatykhanova ◽  
Nurxat Nuraje ◽  
Sarkyt Kudaibergenov

2013 ◽  
Vol 49 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Mangesh Bhalekar ◽  
Savita Sonawane ◽  
Shamkant Shimpi

The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugates were prepared at varying reaction pH (2-6) and evaluated for optimum thiol incorporation, disulphide group content, swelling behavior, rheological properties and mucoadhesive properties. The obtained conjugates characterized in vitro by quantification of immobilized thiol groups; showed maximum thiol incorporation on xyloglucan (7.67 ± 0.14 %) at pH 5. The disulphide group content was found maximum (2.83 ± 0.12) at pH 6. The water uptake at end of 4 h was 5.0 for xyloglucan and was found to decrease in thiolated derivatives with increase in thiolation. Mucoadhesion studies revealed that mucoadhesion of xyloglucan-cysteine conjugate increased more than twice compared to the unmodified polymer. The viscosity of thiomer was more than that of xyloglucan because of formation of disulphide bonds.


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