Hypothalamic-Pituitary-Adrenal Axis Dysfunction by Early Life Stress

2021 ◽  
pp. 136037
Author(s):  
Mario F. Juruena ◽  
Martha Bourne ◽  
Allan H. Young ◽  
Anthony J. Cleare
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Early Life Stress: Long-Term Physiological Impact in Rodents and Primates

Physiology ◽  
2002 ◽  
Vol 17 (4) ◽  
pp. 150-155 ◽  
Author(s):  
Christopher R. Pryce ◽  
Daniela Rüedi-Bettschen ◽  
Andrea C. Dettling ◽  
Joram Feldon
Keyword(s):  
Life Span ◽  
Stress Responses ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Human Infants ◽  
Hypothalamic Pituitary Adrenal ◽  
Physiological Impact ◽  
Pituitary Adrenal Axis

Rat, monkey, and human infants have evolved to expect certain patterns of care. Spontaneous or experimental deviations of care from the norm result in infant stress responses. Hyperactivity of immature stress systems such as the limbic-hypothalamic-pituitary-adrenal axis and the limbic-sympatho-adrenomedullary axis can alter their subsequent reactivity across the life span.

scholarly journals Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

2010 ◽  
Vol 25 (5) ◽  
pp. 268-271 ◽  
Author(s):  
J.J. Mann ◽  
D.M. Currier
Keyword(s):  
Suicidal Behavior ◽  
Early Life ◽  
Life Experiences ◽  
Genetic Differences ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Epigenetic Mechanisms ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Epigenetic Effects ◽  
Pituitary Adrenal Axis

AbstractAlterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

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