scholarly journals Quantitative and Qualitative Analysis of Blood-based Liquid Biopsies to Inform Clinical Decision-making in Prostate Cancer

Author(s):  
Irene Casanova-Salas ◽  
Alejandro Athie ◽  
Paul C. Boutros ◽  
Marzia Del Re ◽  
David T. Miyamoto ◽  
...  
2003 ◽  
Vol 21 (18) ◽  
pp. 3502-3511 ◽  
Author(s):  
Fabio Efficace ◽  
Andrew Bottomley ◽  
David Osoba ◽  
Carolyn Gotay ◽  
Henning Flechtner ◽  
...  

Purpose: The aim of this study was to evaluate whether the inclusion of health-related quality of life (HRQOL), as a part of the trial design in a randomized controlled trial (RCT) setting, has supported clinical decision making for the planning of future medical treatments in prostate cancer. Materials and Methods: A minimum standard checklist for evaluating HRQOL outcomes in cancer clinical trials was devised to assess the quality of the HRQOL reporting and to classify the studies on the grounds of their robustness. It comprises 11 key HRQOL issues grouped into four broader sections: conceptual, measurement, methodology, and interpretation. Relevant studies were identified in a number of databases, including MEDLINE and the Cochrane Controlled Trials Register. Both their HRQOL and traditional clinical reported outcomes were systematically analyzed to evaluate their consistency and their relevance for supporting clinical decision making. Results: Although 54% of the identified studies did not show any differences in traditional clinical end points between treatment arms and 17% showed a difference in overall survival, 74% of the studies showed some difference in terms of HRQOL outcomes. One third of the RCTs provided a comprehensive picture of the whole treatment including HRQOL outcomes to support their conclusions. Conclusion: A minimum set of criteria for assessing the reported outcomes in cancer clinical trials is necessary to make informed decisions in clinical practice. Using a checklist developed for this study, it was found that HRQOL is a valuable source of information in RCTs of treatment in metastatic prostate cancer.


The Lancet ◽  
2003 ◽  
Vol 361 (9362) ◽  
pp. 1045-1053 ◽  
Author(s):  
Ashesh B Jani ◽  
Samuel Hellman

2019 ◽  
Vol 37 (32) ◽  
pp. 2961-2967 ◽  
Author(s):  
David J. VanderWeele ◽  
Emmanuel S. Antonarakis ◽  
Michael A. Carducci ◽  
Robert Dreicer ◽  
Karim Fizazi ◽  
...  

The Prostate ◽  
2015 ◽  
Vol 75 (7) ◽  
pp. 748-757 ◽  
Author(s):  
Mehmet Onur Demirkol ◽  
Ömer Acar ◽  
Burcu Uçar ◽  
Sultan Rana Ramazanoğlu ◽  
Yeşim Sağlıcan ◽  
...  

2021 ◽  
Author(s):  
Maurice Henkel ◽  
Tobias Horn ◽  
Francois Leboutte ◽  
Pawel Trotsenko ◽  
Sarah G. Dugas ◽  
...  

Abstract Introduction Physicians spend more than half of their workday interacting with health information systems to care for their patients. Effective data management that provides physicians with comprehensive patient information from various information systems is required to ensure high quality clinical decision making.Objectives We evaluated the impact of a novel, CE-certified clinical decision support tool on physician’s effectiveness and satisfaction in the clinical decision-making process.Methods Using pre-therapeutic prostate cancer management cases, we compared physician’s expenditure of time, data quality, and user satisfaction in the decision-making process comparing the current standard with the software. Ten urologists from our department conducted the diagnostic work-up to the treatment decision for a total of 10 patients using both approaches.Results A significant reduction in the physician’s expenditure of time for the decision-making process by -59.9 % (p < 0,001) was found using the software. System usage showed a high positive effect on evaluated data quality parameters completeness (Cohen's d of 2.36), format (6.15), understandability (2.64), as well as user satisfaction (4.94).Conclusion The software demonstrated that effective data management can improve physician’s effectiveness and satisfaction in the clinical decision-making process. Further development is needed to map more complex patient pathways, such as the follow-up treatment of prostate cancer.


2014 ◽  
Vol 41 (12) ◽  
pp. 2222-2231 ◽  
Author(s):  
Francesco Ceci ◽  
Ken Herrmann ◽  
Paolo Castellucci ◽  
Tiziano Graziani ◽  
Christina Bluemel ◽  
...  

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