The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis

2006 ◽  
Vol 41 (4) ◽  
pp. 380-386 ◽  
Author(s):  
Jeroen J.M. Hoozemans ◽  
Jens Stieler ◽  
Elise S. van Haastert ◽  
Robert Veerhuis ◽  
Annemieke J.M. Rozemuller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Cycle ◽  
Protein Expression ◽  
Unfolded Protein Response ◽  
Neuronal Cell ◽  
Cell Cycle Protein ◽  
Disease Pathogenesis ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Rab6 is a Modulator of the Unfolded Protein Response: Implications for Alzheimer's Disease

2012 ◽  
Vol 28 (4) ◽  
pp. 917-929 ◽  
Author(s):  
Hyung Lim Elfrink ◽  
Rob Zwart ◽  
María L. Cavanillas ◽  
Adam Jay Schindler ◽  
Frank Baas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response

2007 ◽  
Vol 177 (6) ◽  
pp. 1017-1027 ◽  
Author(s):  
Alicia A. Bicknell ◽  
Anna Babour ◽  
Christine M. Federovitch ◽  
Maho Niwa
Keyword(s):  
Cell Cycle ◽  
Unfolded Protein Response ◽  
Normal Cell ◽  
Growth Conditions ◽  
Unfolded Protein ◽  
Functional Capabilities ◽  
Cellular Events ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Upr Pathway

The unfolded protein response (UPR) pathway helps cells cope with endoplasmic reticulum (ER) stress by activating genes that increase the ER's functional capabilities. We have identified a novel role for the UPR pathway in facilitating budding yeast cytokinesis. Although other cell cycle events are unaffected by conditions that disrupt ER function, cytokinesis is sensitive to these conditions. Moreover, efficient cytokinesis requires the UPR pathway even during unstressed growth conditions. UPR-deficient cells are defective in cytokinesis, and cytokinesis mutants activate the UPR. The UPR likely achieves its role in cytokinesis by sensing small changes in ER load and making according changes in ER capacity. We propose that cytokinesis is one of many cellular events that require a subtle increase in ER function and that the UPR pathway has a previously uncharacterized housekeeping role in maintaining ER plasticity during normal cell growth.

scholarly journals The unfolded protein response is activated in the olfactory system in Alzheimer’s disease

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Helen C. Murray ◽  
Birger Victor Dieriks ◽  
Molly E. V. Swanson ◽  
Praju Vikas Anekal ◽  
Clinton Turner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Olfactory System ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

The Unfolded Protein Response Is Involved in the Pathology of Alzheimer's Disease

2002 ◽  
Vol 977 (1) ◽  
pp. 349-355 ◽  
Author(s):  
TAKASHI KUDO ◽  
TAIICHI KATAYAMA ◽  
KAZUNORI IMAIZUMI ◽  
YUKA YASUDA ◽  
MISAKO YATERA ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

P1-377: The unfolded protein response is associated with increased GSK-3beta activity in Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S208-S208
Author(s):  
Jeroen J. Hoozemans ◽  
Elise S. van Haastert ◽  
Sidhartha M. Chafekar ◽  
Robert Veerhuis ◽  
Piet Eikelenboom ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response
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