Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats

2006 ◽  
Vol 200 (2) ◽  
pp. 392-397 ◽  
Author(s):  
Yutaka Nishio ◽  
Masao Koda ◽  
Keiko Kitajo ◽  
Minoru Seto ◽  
Katsuhiko Hata ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Delayed Treatment ◽  
Rho Kinase Inhibitor ◽  
Cord Injury

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery After Spinal Cord Injury in Adult Rats

2009 ◽  
pp. 110306202455053
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury

PACAP Stimulates Functional Recovery after Spinal Cord Injury through Axonal Regeneration

2014 ◽  
Vol 54 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Masashi Tsuchida ◽  
Tomoya Nakamachi ◽  
Kouichi Sugiyama ◽  
Daisuke Tsuchikawa ◽  
Jun Watanabe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Cord Injury

scholarly journals Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury

2020 ◽  
Vol 31 (3) ◽  
pp. 623-641.e8 ◽  
Author(s):  
Qi Han ◽  
Yuxiang Xie ◽  
Josue D. Ordaz ◽  
Andrew J. Huh ◽  
Ning Huang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Cord Injury ◽  
Cellular Energetics

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury in Adult Rats

2009 ◽  
Vol 26 (10) ◽  
pp. 1745-1757 ◽  
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury

Intraspinal cord graft of autologous activated Schwann cells efficiently promotes axonal regeneration and functional recovery after rat's spinal cord injury

2009 ◽  
Vol 1256 ◽  
pp. 149-161 ◽  
Author(s):  
De-Xiang Ban ◽  
Xiao-Hong Kong ◽  
Shi-Qing Feng ◽  
Guang-Zhi Ning ◽  
Jia-Tong Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Schwann Cells ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Cord Injury

scholarly journals The Biology of Regeneration Failure and Success After Spinal Cord Injury

2018 ◽  
Vol 98 (2) ◽  
pp. 881-917 ◽  
Author(s):  
Amanda Phuong Tran ◽  
Philippa Mary Warren ◽  
Jerry Silver
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Molecular Mechanisms ◽  
Glial Scar ◽  
Perineuronal Net ◽  
Physical Trauma ◽  
Axonal Regrowth ◽  
Cord Injury

Since no approved therapies to restore mobility and sensation following spinal cord injury (SCI) currently exist, a better understanding of the cellular and molecular mechanisms following SCI that compromise regeneration or neuroplasticity is needed to develop new strategies to promote axonal regrowth and restore function. Physical trauma to the spinal cord results in vascular disruption that, in turn, causes blood-spinal cord barrier rupture leading to hemorrhage and ischemia, followed by rampant local cell death. As subsequent edema and inflammation occur, neuronal and glial necrosis and apoptosis spread well beyond the initial site of impact, ultimately resolving into a cavity surrounded by glial/fibrotic scarring. The glial scar, which stabilizes the spread of secondary injury, also acts as a chronic, physical, and chemo-entrapping barrier that prevents axonal regeneration. Understanding the formative events in glial scarring helps guide strategies towards the development of potential therapies to enhance axon regeneration and functional recovery at both acute and chronic stages following SCI. This review will also discuss the perineuronal net and how chondroitin sulfate proteoglycans (CSPGs) deposited in both the glial scar and net impede axonal outgrowth at the level of the growth cone. We will end the review with a summary of current CSPG-targeting strategies that help to foster axonal regeneration, neuroplasticity/sprouting, and functional recovery following SCI.

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