Stem Cells in Bone Grafting: Trinity Allograft with Stem Cells and Collagen/Beta-Tricalcium Phosphate with Concentrated Bone Marrow Aspirate

2010 ◽  
Vol 15 (4) ◽  
pp. 611-619 ◽  
Author(s):  
Gregory P. Guyton ◽  
Stuart D. Miller
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Tricalcium Phosphate ◽  
Bone Grafting ◽  
Bone Marrow Aspirate ◽  
Beta Tricalcium Phosphate ◽  
Concentrated Bone Marrow

scholarly journals Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Jean-Philippe Hauzeur ◽  
Valérie Gangji
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adult Stem Cells ◽  
Bone Marrow Aspirate ◽  
Direct Injection ◽  
Case Series ◽  
Autologous Bone Marrow ◽  
Bone Necrosis ◽  
Concentrated Bone Marrow ◽  
Made In

Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection—15 to 150 ml—was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.

Beta-tricalcium phosphate promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells through macrophages

2021 ◽  
Vol 16 (2) ◽  
pp. 025005
Author(s):  
Mengting Zheng ◽  
Mengjia Weng ◽  
Xiaoyu Zhang ◽  
Ruomei Li ◽  
Qian Tong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Tricalcium Phosphate ◽  
Beta Tricalcium Phosphate
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