Single-cell RNA sequencing of mouse neural stem cell differentiation reveals adverse effects of cadmium on neurogenesis

2021 ◽  
Vol 148 ◽  
pp. 111936
Author(s):  
Bo Song ◽  
Guiya Xiong ◽  
Huan Luo ◽  
Zhenzi Zuo ◽  
Zhijun Zhou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Adverse Effects ◽  
Single Cell ◽  
Rna Sequencing ◽  
Neural Stem Cell ◽  
Stem Cell Differentiation ◽  
Single Cell Rna Sequencing

Functional Evaluation of Neural Stem Cell Differentiation by Single Cell Calcium Imaging

2011 ◽  
Vol 6 (3) ◽  
pp. 288-296 ◽  
Author(s):  
Maria Francisca Eiriz ◽  
Sofia Grade ◽  
Alexandra Rosa ◽  
Sara Xapelli ◽  
Liliana Bernardino ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Single Cell ◽  
Neural Stem Cell ◽  
Calcium Imaging ◽  
Stem Cell Differentiation ◽  
Functional Evaluation ◽  
Cell Calcium

Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development

2020 ◽  
Vol 21 (1) ◽  
pp. 163-181
Author(s):  
Guangdun Peng ◽  
Guizhong Cui ◽  
Jincan Ke ◽  
Naihe Jing
Keyword(s):  
Stem Cell ◽  
Single Cell ◽  
Rna Sequencing ◽  
Cell Fate ◽  
Cell Lineage ◽  
Stem Cell Differentiation ◽  
Early Embryo ◽  
Stem Cell Lineage ◽  
Single Cell Rna Sequencing ◽  
Cell Organization

Embryonic development and stem cell differentiation provide a paradigm to understand the molecular regulation of coordinated cell fate determination and the architecture of tissue patterning. Emerging technologies such as single-cell RNA sequencing and spatial transcriptomics are opening new avenues to dissect cell organization, the divergence of morphological and molecular properties, and lineage allocation. Rapid advances in experimental and computational tools have enabled researchers to make many discoveries and revisit old hypotheses. In this review, we describe the use of single-cell RNA sequencing in studies of molecular trajectories and gene regulation networks for stem cell lineages, while highlighting the integratedexperimental and computational analysis of single-cell and spatial transcriptomes in the molecular annotation of tissue lineages and development during postimplantation gastrulation.

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