Treatment efficacy of in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) in human immunodeficiency virus-1 (HIV-1) serodiscordant couples: A life table analysis

2004 ◽  
Vol 82 ◽  
pp. S186-S187 ◽  
Author(s):  
J.E. Pena ◽  
M.C. Chu ◽  
M.H. Thornton ◽  
M.V. Sauer
Keyword(s):  
Human Immunodeficiency Virus ◽  
In Vitro Fertilization ◽  
Treatment Efficacy ◽  
Life Table Analysis ◽  
Vitro Fertilization ◽  
Immunodeficiency Virus ◽  
Table Analysis ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

In‐vitro fertilization and embryo transfer: Prospects of pregnancy by life‐table analysis

1986 ◽  
Vol 144 (13) ◽  
pp. 682-683 ◽  
Author(s):  
Gabor T. Kovacs ◽  
Peter Rogers ◽  
John F. Leeton ◽  
Alan O. Trounson ◽  
Carl Wood ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Life Table ◽  
Embryo Transfer ◽  
Life Table Analysis ◽  
Vitro Fertilization ◽  
Table Analysis

scholarly journals HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Wei Zou ◽  
Juanjuan Xing ◽  
Shijie Zou ◽  
Mei Jiang ◽  
Xinping Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Progenitor Cells ◽  
Cell Loss ◽  
Underlying Mechanism ◽  
Humanized Mice ◽  
Hematopoietic Stem ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

Abstract Background A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive. Nef plays an important role in HIV-1 induced T cell loss and disease progression, but it is not known whether Nef participates in other hematopoietic abnormalities associated with infection. Results In the current study we investigated the influence of HIV-1LAI Nef (LAI Nef) on the development of hematopoietic stem/progenitor cells (HSPCs) into myeloid-erythroid lineage cells, and found that nef expression in HSPCs blocked their differentiation both in vitro and in humanized mice reconstituted with nef-expressing HSPCs. Conclusions Our novel findings demonstrate LAI Nef compromised the development of myeloid-erythroid lineage cells, and therapeutics targeting Nef would be promising in correcting HIV-1 associated hematopoietic abnormalities.

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