Basal release of urokinase plasminogen activator, plasminogen activator inhibitor-1, and soluble plasminogen activator receptor from separated and cultured endometriotic and endometrial stromal and epithelial cells

2005 ◽  
Vol 83 (4) ◽  
pp. 1155-1160 ◽  
Author(s):  
C BRUSE ◽  
Y GUAN ◽  
M CARLBERG ◽  
K CARLSTROM ◽  
A BERGQVIST
Keyword(s):  
Epithelial Cells ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Urokinase Plasminogen Activator ◽  
Plasminogen Activator Inhibitor 1 ◽  
Basal Release ◽  
Plasminogen Activator Receptor ◽  
Activator Inhibitor

scholarly journals Thrombo-inflammatory biomarkers to predict sepsis outcome

2021 ◽  
Vol 35 ◽  
pp. 205873842110485
Author(s):  
Alaa Efat ◽  
Sabry Abdallah Shoeib ◽  
Ayman F Arafa ◽  
Ashraf Abdelraof Dawod ◽  
Mohamad A Abd ElHafez ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Urokinase Plasminogen Activator ◽  
Plasminogen Activator Inhibitor 1 ◽  
Urokinase Plasminogen Activator Receptor ◽  
Cutoff Value ◽  
Plasminogen Activator Receptor ◽  
Activator Inhibitor ◽  
Pai 1

Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses to infection and septic shock. Soluble urokinase plasminogen activator receptor (SuPAR) and plasminogen activator inhibitor-1(PAI-1) concentration positively correlate to the activation level of the immune system, and are markers of disease severity and aggressiveness. Objective: The study aimed to identify the blood level of plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase plasminogen activator receptor (SuPAR) in sepsis and its association with mortality. Patient and methods: This is an observational prospective study that enrolled 60 adult patients with sepsis (according to SOFA), admitted to Menoufia and Zagazig university hospitals during the period from December 2019 till October 2020. Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase plasminogen activator receptor (SuPAR) were checked in all participants. Results: SuPAR and PAI.1 were significant independent predictors of hospital mortality. SuPAR showed sensitivity 100%, specificity 95.9%, and accuracy 94% for prediction of early mortality at a cutoff value of 13.4(pg/ml). While, PAI-1 demonstrated sensitivity 100%, specificity 93.9%, and accuracy of 95% at a cutoff value of 122.5 for predicting mortality. Conclusion: PAI-1 and suPAR were significant predictors of hospital mortality among sepsis patients. The sample size was relatively small, which may have decreased the statistical power of the results of the present study. Hence, additional studies with large sample sizes are required for further validation of the present results.

scholarly journals Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer

2013 ◽  
Vol 7 (5) ◽  
pp. 403-411 ◽  
Author(s):  
Earl Gillespie ◽  
Susan E. Leeman ◽  
Luisa A. Watts ◽  
Jennifer A. Coukos ◽  
Michael J. O'Brien ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Colonic Epithelial Cells ◽  
Activator Inhibitor
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