A randomized, assessor-blind, dose-response trial in patients undergoing controlled ovarian stimulation for IVF/ICSI with a novel recombinant FSH preparation (FE 999049) derived from a human cell-line

2013 ◽  
Vol 100 (3) ◽  
pp. S59
Author(s):  
J.-C. Arce ◽  
A. Nyboe Andersen ◽  
M. Fernández-Sánchez ◽  
E. Bosch ◽  
H. Visnova ◽  
...  
Keyword(s):  
Cell Line ◽  
Dose Response ◽  
Human Cell ◽  
Ovarian Stimulation ◽  
Human Cell Line ◽  
Controlled Ovarian Stimulation ◽  
Recombinant Fsh ◽  
Response Trial

Dose-response endocrine profiles for a novel recombinant FSH preparation (FE 999049) derived from a human cell-line

2013 ◽  
Vol 100 (3) ◽  
pp. S18
Author(s):  
A. Nyboe Andersen ◽  
P. Barri ◽  
J.A. García-Velasco ◽  
P. De Sutter ◽  
E. Bosch ◽  
...  
Keyword(s):  
Cell Line ◽  
Dose Response ◽  
Human Cell ◽  
Human Cell Line ◽  
Recombinant Fsh ◽  
Endocrine Profiles

scholarly journals Comparative pharmacology of a new recombinant FSH expressed by a human cell line

2017 ◽  
Vol 6 (5) ◽  
pp. 297-305 ◽  
Author(s):  
Wolfgang Koechling ◽  
Daniel Plaksin ◽  
Glenn E Croston ◽  
Janni V Jeppesen ◽  
Kirsten T Macklon ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Cell ◽  
Chinese Hamster ◽  
Human Cell Line ◽  
Therapeutic Agents ◽  
Recombinant Fsh ◽  
Genetic Ablation ◽  
Follitropin Alfa ◽  
Therapeutic Protocols

Recombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylation, and have distinct pharmacokinetic and pharmacodynamic profiles in women. Comparative experiments demonstrated that follitropin delta and follitropin alfa displayed the same in vitro potency at the human FSH receptor, but varied in their pharmacokinetics in mouse and rat. While follitropin delta clearance from serum depended in part on the hepatic asialoglycoprotein receptor (ASGPR), follitropin alfa clearance was unaffected by ASGPR inhibition in rat or genetic ablation in mice. The distinct properties of follitropin delta and follitropin alfa are likely to contribute to the differing pharmacokinetic and pharmacodynamic profiles observed in women and to influence their efficacy in therapeutic protocols for the treatment of infertility.

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