scholarly journals Clinical pregnancy (CP) and live birth (LB) increase significantly with each additional fertilized oocyte up to 9 and cp declines after that: an analysis of 16,032 first in vitro fertilization (IVF) cycles from the SART registry

2018 ◽  
Vol 110 (4) ◽  
pp. e44
Author(s):  
S. Smeltzer ◽  
K. Acharya ◽  
T. Truong ◽  
C. Pieper ◽  
S.J. Muasher
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Clinical Pregnancy ◽  
Vitro Fertilization

scholarly journals Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

2020 ◽  
Author(s):  
Wenjia BO ◽  
Ning Zhang
Keyword(s):  
In Vitro Fertilization ◽  
Fallopian Tube ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Clinical Pregnancy ◽  
Birth Rates ◽  
Vitro Fertilization ◽  
Live Birth Rates

Abstract Background: To investigate the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to simple fallopian tube factors. METHODS:We retrospectively analyzed the clinical data of 854 cycles from the simple fallopian tube factor in vitro fertilization fresh embryo transfer. The clinical data of 854 cycles from January 2010 to December 2018 was divided into 7 groups according to the progesterone level on human chrionic gonadotropin day. Live birth rates and observe trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups: Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone≥1.25ng/ml). We then compared the ovulation results and clinical outcomes between the 3 groups. RESULTS There were no significant differences in age, infertility years, Gonadotropin dosage, Gonadotropin days, Luteinizing hormone level on human chrionic gonadotropinday, 2pronuclear fertilization rate, clinical pregnancy rate, live birth rates, full-term birth rate, and preterm birth rate among the three groups, but body mass index(P = 0.001), basal luteinizing hormone (P = 0.034), estrogen peak (P ＜0.001), number of oocytes obtained (P＜0.001) were significantly different. CONCLUSION The level of progesterone on human chrionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0-1.25ng/ml may lead to good clinical pregnancy outcomes.

scholarly journals Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

2019 ◽  
Vol 16 (6) ◽  
pp. 995 ◽  
Author(s):  
Cheng-Hsuan Wu ◽  
Tsung-Hsien Lee ◽  
Shun-Fa Yang ◽  
Hui-Mei Tsao ◽  
Yu-Jun Chang ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cohort Analysis ◽  
Embryo Implantation ◽  
Clinical Pregnancy ◽  
Birth Rates ◽  
Vitro Fertilization ◽  
Live Birth Rates ◽  
Increased Risk

The aim of this study was to examine the association between interleukin (IL) genes polymorphisms and in vitro fertilization (IVF) outcome. A prospective cohort analysis was performed at a Women’s Hospital IVF centre of 1015 female patients undergoing fresh non-donor IVF cycles. The effects of the following six single nucleotide polymorphisms (SNPs) in five IL genes on IVF outcomes were explored: IL-1α (rs1800587 C/T), IL-3 (rs40401 C/T), IL-6 (rs1800795 C/G), IL-15 (rs3806798 A/T), IL-18 (rs187238 C/G) and IL-18 (rs1946518 G/T). The main outcome measures included clinical pregnancy, embryo implantation, abortion and live birth rates. There were no statistically significant differences in clinical pregnancy, embryo implantation and live birth rates in the analysis of 1015 patients attempting their first cycle of IVF. Infertile women with IL-3 homozygous major genotype had a higher abortion rate than those with heterozygous and homozygous minor genotype (16.5% vs. 7.9%, P = 0.025). In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients. Future studies with inclusion of other ethnic populations must be conducted to confirm the findings of this study.

scholarly journals The association between preconception fruit and vegetable intake in relation to in-vitro fertilization treatment outcome among women attempting fertility

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Dimitrios Karayiannis ◽  
Meropi Kontogianni ◽  
Minas Mastrominas ◽  
Nikos Yiannakouris
Keyword(s):  
Physical Activity ◽  
In Vitro Fertilization ◽  
Live Birth ◽  
Embryo Quality ◽  
Clinical Pregnancy ◽  
Adjusted Relative Risk ◽  
Fruit And Vegetable ◽  
Vitro Fertilization ◽  
Intermediate Outcomes

AbstractIntroductionAdequate intake of fruits and vegetables (F&V) has been long promoted as a public health priority based on the evidence supporting various health benefits attributed to these food groups. Their effects on reproductive outcomes, however, remain poorly explored. F&V intake has been positively associated with embryo quality in women undergoing in-vitro fertilization (IVF) but there is lack of data regarding potential associations with IVF final outcomes (clinical pregnancy and live birth). Thus, the aim of this study was to evaluate habitual F&V intake in relation to clinical pregnancy and live birth among women undergoing infertility treatment.Materials and MethodsNulliparous non-obese women [n = 244, 22–41 years old, body mass index (BMI) < 30 kg/m2] undergoing their first IVF cycle were recruited from an Assisted Conception Unit in Athens, Greece, between November 2013 and September 2016. Habitual F&V intake was estimated via a validated for the Greek population semi-quantitative food-frequency questionnaire and expressed in servings/day. Intermediate outcomes (i.e. oocyte yield and embryo quality measures) and clinical endpoints (implantation, clinical pregnancy and live birth) were prospectively recorded. Generalized linear models adjusting for age, ovarian stimulation protocol, BMI, physical activity, anxiety levels, infertility diagnosis, caloric intake and supplements use were used to test associations between F&V intake and IVF outcomes.ResultsOverall, 229 women (93.9%) had an embryo transfer, 104 (42.6%) achieved a clinical pregnancy and 99 (40.5%) had a live birth. Women with a clinical pregnancy and live birth did not differ in age, BMI, smoking habits, physical activity or stress levels, compared to those who did not achieve pregnancy (all P > 0.05). Compared to women with IVF failure, those achieving clinical pregnancy and live birth reported consuming more fruits (median values: 1.77 vs. 1.49 servings/day and 1.77 vs. 1.41 servings/day, respectively) and more vegetables (1.79 vs. 1.37 servings/day and 1.89 vs. 1.36 servings/day, respectively), all P < 0.05. No significant association between F&V intake and IVF intermediate outcomes was recorded. The multivariable-adjusted relative risk (95% confidence interval) for clinical pregnancy for increasing intake of fruit and vegetable (servings/day, continuous) was 1.23 (1.06–1.44) and 1.25 (1.02–1.57), respectively, and for live birth it was 1.29 (1.10–1.51) and 1.36 (1.10–1.71), respectively.DiscussionHigher pre-treatment F&V was related to higher probability of clinical pregnancy and live birth among women undergoing IVF. These results highlight the importance of dietary influences on fertility and suggest the need for additional research on the effects of F&V intake on reproductive endpoints in women conceiving through infertility treatments.

scholarly journals Efficacy of intralipid administration to improve in vitro fertilization outcomes: A systematic review and meta-analysis

2021 ◽  
Vol 48 (3) ◽  
pp. 203-210
Author(s):  
E Jung Han ◽  
Hye Nam Lee ◽  
Min Kyoung Kim ◽  
Sang Woo Lyu ◽  
Woo Sik Lee
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Live Birth ◽  
Meta Analysis ◽  
Clinical Pregnancy ◽  
Implantation Failure ◽  
Ongoing Pregnancy ◽  
Vitro Fertilization

We performed a systematic review and meta-analysis to evaluate whether intralipid administration improved the outcomes of in vitro fertilization. Online databases (PubMed, Cochrane Library, Medline, and Embase) were searched until March 2020. Only randomized controlled trials (RCTs) that assessed the role of intralipid administration during in vitro fertilization were considered. We analyzed the rates of clinical pregnancy and live birth as primary outcomes. Secondary outcomes included the rates of chemical pregnancy, ongoing pregnancy, and missed abortion. We reviewed and assessed the eligibility of 180 studies. Five RCTs including 840 patients (3 RCTs: women with repeated implantation failure, 1 RCT: women with recurrent spontaneous abortion, 1 RCT: women who had experienced implantation failure more than once) met the selection criteria. When compared with the control group, intralipid administration significantly improved the clinical pregnancy rate (risk ratio [RR], 1.48; 95% confidence interval [CI], 1.23–1.79), ongoing pregnancy rate (RR, 1.82; 95% CI, 1.31–2.53), and live birth rate (RR, 1.85; 95% CI, 1.44–2.38). However, intralipid administration had no beneficial effect on the miscarriage rate (RR, 0.75; 95% CI, 0.48–1.17). A funnel plot analysis revealed no publication bias. Our findings suggest that intralipid administration may benefit women undergoing in vitro fertilization, especially those who have experienced repeated implantation failure or recurrent spontaneous abortion. However, larger, well-designed studies are needed to confirm these findings.

Predictive Model for Live Birth at 12 Months After Starting In-Vitro Fertilization Treatment

MedPharmRes ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 5-20
Author(s):  
Vu Ho ◽  
Toan Pham ◽  
Tuong Ho ◽  
Lan Vuong
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cox Regression ◽  
Financial Burden ◽  
Oocyte Retrieval ◽  
Operating Characteristics ◽  
Vitro Fertilization ◽  
Cox Regression Analysis ◽  
Significant Difference

IVF carries a considerable physical, emotional and financial burden. Therefore, it would be useful to be able to predict the likelihood of success for each couple. The aim of this retrospective cohort study was to develop a prediction model to estimate the probability of a live birth at 12 months after one completed IVF cycle (all fresh and frozen embryo transfers from the same oocyte retrieval). We analyzed data collected from 2600 women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) at a single center in Vietnam between April 2014 and December 2015. All patients received gonadotropin-releasing hormone (GnRH) antagonist stimulation, followed by fresh and/or frozen embryo transfer (FET) on Day 3. Using Cox regression analysis, five predictive factors were identified: female age, total dose of recombinant follicle stimulating hormone used, type of trigger, fresh or FET during the first transfer, and number of subsequent FET after the first transfer. The area under the receiver operating characteristics curve for the final model was 0.63 (95% confidence interval [CI] 0.60‒0.65) and 0.60 (95% CI 0.57‒0.63) for the validation cohort. There was no significant difference between the predicted and observed probabilities of live birth (Hosmer-Lemeshow test, p > 0.05). The model developed had similar discrimination to existing models and could be implemented in clinical practice.

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