Genetic analysis of a Taiwanese family identifies a DMRT3-OAS3 interaction that is involved in human sexual differentiation through the regulation of ESR1 expression

Abscisic acid normally inhibits growth and male sexual differentiation (antheridia formation) in gametophytes of the fern Ceratopteris. Abscisic acid resistant mutants show increased growth and sexual differentiation in comparison with the wild type when cultured in the presence of abscisic acid. Two different mutants that confer resistance to the effects of abscisic acid have been fully characterized. One shows moderate resistance and the other strong resistance. The mutations involve separate but linked loci. Recombination between the loci yields double mutant (cis) recombinants that exhibit additive effects and show exceptional levels of abscisic acid resistance.

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Genetic Analysis of Four Sexual Differentiation Process Proteins (isp4/SDPs) in Chaetomium thermophilum and Thermomyces lanuginosus Reveals Their Distinct Roles in Development

Frontiers in Microbiology ◽

10.3389/fmicb.2019.02994 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 1

Author(s):

Xiang-Li Xie ◽

Yi Wei ◽

Yan-Yue Song ◽

Guan-Ming Pan ◽

Li-Na Chen ◽

...

Keyword(s):

Genetic Analysis ◽

Sexual Differentiation ◽

Thermomyces Lanuginosus ◽

Differentiation Process ◽

Chaetomium Thermophilum

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A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females.

Genetics ◽

10.1093/genetics/139.4.1649 ◽

1995 ◽

Vol 139 (4) ◽

pp. 1649-1661 ◽

Cited By ~ 2

Author(s):

B A Chase ◽

B S Baker

Keyword(s):

Drosophila Melanogaster ◽

Genetic Analysis ◽

Sexual Differentiation ◽

Point Mutations ◽

Regulatory Genes ◽

Sexually Dimorphic ◽

Specific Product ◽

Sex Type ◽

A Cell ◽

Female Specific

Abstract Sex-type in Drosophila melanogaster is controlled by a hierarchically acting set of regulatory genes. At the terminus of this hierarchy lie those regulatory genes responsible for implementing sexual differentiation: genes that control the activity of target loci whose products give rise to sexually dimorphic phenotypes. The genetic analysis of the intersex (ix) gene presented here demonstrates that ix is such a terminally positioned regulatory locus. The ix locus has been localized to the cytogenetic interval between 47E3-6 and 47F11-18. A comparison of the morphological and behavioral phenotypes of homozygotes and hemizygotes for three point mutations at ix indicates that the null phenotype of ix is to transform diplo-X animals into intersexes while leaving haplo-X animals unaffected. Analysis of X-ray induced, mitotic recombination clones lacking ix+ function in the abdomen of diplo-X individuals indicates that the ix+ product functions in a cell-autonomous manner and that it is required at least until the termination of cell division in this tissue. Taken together with previous analyses, our results indicate that the ix+ product is required to function with the female-specific product of doublesex to implement appropriate female sexual differentiation in diplo-X animals.

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A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila melanogaster.

Genetics ◽

10.1093/genetics/136.1.195 ◽

1994 ◽

Vol 136 (1) ◽

pp. 195-207

Author(s):

M A Pultz ◽

G S Carson ◽

B S Baker

Keyword(s):

Drosophila Melanogaster ◽

Genetic Analysis ◽

Sex Determination ◽

Temperature Sensitivity ◽

Sexual Differentiation ◽

Regulatory Genes ◽

Temperature Sensitive ◽

Partial Loss ◽

Female Progeny ◽

Regulatory Cascade

Abstract Sex determination in Drosophila is controlled by a cascade of regulatory genes. Here we describe hermaphrodite (her), a new component of this regulatory cascade with pleiotropic zygotic and maternal functions. Zygotically, her+ function is required for female sexual differentiation: when zygotic her+ function is lacking, females are transformed to intersexes. Zygotic her+ function may also play a role in male sexual differentiation. Maternally, her+ function is needed to ensure the viability of female progeny: a partial loss of her+ function preferentially kills daughters. In addition, her has both zygotic and maternal functions required for viability in both sexes. Temperature sensitivity prevails for all known her alleles and for all of the her phenotypes described above, suggesting that her may participate in an intrinsically temperature-sensitive process. This analysis of four her alleles also indicates that the zygotic and maternal components of of her function are differentially mutable. We have localized her cytologically to 36A3-36A11.

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Genetic analysis of the Mullerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

Genes & Development ◽

10.1101/gad.10.20.2577 ◽

1996 ◽

Vol 10 (20) ◽

pp. 2577-2587 ◽

Cited By ~ 227

Author(s):

Y Mishina ◽

R Rey ◽

M J Finegold ◽

M M Matzuk ◽

N Josso ◽

...

Keyword(s):

Signal Transduction ◽

Genetic Analysis ◽

Sexual Differentiation ◽

Signal Transduction Pathway ◽

Transduction Pathway ◽

Müllerian Inhibiting Substance ◽

Mullerian Inhibiting Substance

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Androgen-induced plasticity at a “vocal” neuromuscular synapse

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100167895 ◽

1994 ◽

Vol 52 ◽

pp. 32-33

Author(s):

Darcy B. Kelley ◽

Martha L. Tobias ◽

Mark Ellisman

Keyword(s):

Xenopus Laevis ◽

Motor Neurons ◽

Sexual Differentiation ◽

Molecular Basis ◽

Neuromuscular Synapse ◽

Sexually Dimorphic ◽

Intracellular Protein ◽

Developmental Program ◽

Androgen Action ◽

Clawed Frog

Brain and muscle are sexually differentiated tissues in which masculinization is controlled by the secretion of androgens from the testes. Sensitivity to androgen is conferred by the expression of an intracellular protein, the androgen receptor. A central problem of sexual differentiation is thus to understand the cellular and molecular basis of androgen action. We do not understand how hormone occupancy of a receptor translates into an alteration in the developmental program of the target cell. Our studies on sexual differentiation of brain and muscle in Xenopus laevis are designed to explore the molecular basis of androgen induced sexual differentiation by examining how this hormone controls the masculinization of brain and muscle targets.Our approach to this problem has focused on a highly androgen sensitive, sexually dimorphic neuromuscular system: laryngeal muscles and motor neurons of the clawed frog, Xenopus laevis. We have been studying sex differences at a synapse, the laryngeal neuromuscular junction, which mediates sexually dimorphic vocal behavior in Xenopus laevis frogs.

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