Genetic Analysis of Four Sexual Differentiation Process Proteins (isp4/SDPs) in Chaetomium thermophilum and Thermomyces lanuginosus Reveals Their Distinct Roles in Development

Abscisic acid normally inhibits growth and male sexual differentiation (antheridia formation) in gametophytes of the fern Ceratopteris. Abscisic acid resistant mutants show increased growth and sexual differentiation in comparison with the wild type when cultured in the presence of abscisic acid. Two different mutants that confer resistance to the effects of abscisic acid have been fully characterized. One shows moderate resistance and the other strong resistance. The mutations involve separate but linked loci. Recombination between the loci yields double mutant (cis) recombinants that exhibit additive effects and show exceptional levels of abscisic acid resistance.

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Genetic analysis of a Taiwanese family identifies a DMRT3-OAS3 interaction that is involved in human sexual differentiation through the regulation of ESR1 expression

Fertility and Sterility ◽

10.1016/j.fertnstert.2020.03.008 ◽

2020 ◽

Vol 114 (1) ◽

pp. 133-143 ◽

Cited By ~ 1

Author(s):

Chia-Lung Tsai ◽

Chi-Neu Tsai ◽

Yun-Shien Lee ◽

Hsin-Shih Wang ◽

Li-Yu Lee ◽

...

Keyword(s):

Genetic Analysis ◽

Sexual Differentiation ◽

Esr1 Expression

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Azoospermia in XX male

Urologia Journal ◽

10.1177/039156039205901s85 ◽

1992 ◽

Vol 59 (1_suppl) ◽

pp. 261-263

Author(s):

S. Montagna ◽

G. Zacchè ◽

C. Bondavalli

Keyword(s):

Young Adult ◽

Sexual Differentiation ◽

Early Phase ◽

Rare Case ◽

Differentiation Process ◽

Chromosome X ◽

Testis Differentiation ◽

Genital Ambiguity ◽

Xx Male

The Authors report a case of azoospermia in a young adult who, though phenotypically a male, was a carrier of karyotype 46 XX. It is a rare case and is due to the precocious migration of fragment Y which produces testis differentiation on chromosome X. These sexual differentiation anomalies produce no genital ambiguity because the process takes place in the very early phase of the sexual differentiation process.

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Prenatal Exposures of Male Rats to the Environmental Chemicals Bisphenol A and Di(2-Ethylhexyl) Phthalate Impact the Sexual Differentiation Process

Endocrinology ◽

10.1210/en.2015-1077 ◽

2015 ◽

Vol 156 (12) ◽

pp. 4672-4683 ◽

Cited By ~ 38

Author(s):

Fatma M. Abdel-Maksoud ◽

Khrystyna R. Leasor ◽

Kate Butzen ◽

Timothy D. Braden ◽

Benson T. Akingbemi

Keyword(s):

Bisphenol A ◽

Sexual Differentiation ◽

Environmental Chemicals ◽

Male Rats ◽

Differentiation Process ◽

Prenatal Exposures ◽

Ethylhexyl Phthalate

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A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females.

Genetics ◽

10.1093/genetics/139.4.1649 ◽

1995 ◽

Vol 139 (4) ◽

pp. 1649-1661 ◽

Cited By ~ 2

Author(s):

B A Chase ◽

B S Baker

Keyword(s):

Drosophila Melanogaster ◽

Genetic Analysis ◽

Sexual Differentiation ◽

Point Mutations ◽

Regulatory Genes ◽

Sexually Dimorphic ◽

Specific Product ◽

Sex Type ◽

A Cell ◽

Female Specific

Abstract Sex-type in Drosophila melanogaster is controlled by a hierarchically acting set of regulatory genes. At the terminus of this hierarchy lie those regulatory genes responsible for implementing sexual differentiation: genes that control the activity of target loci whose products give rise to sexually dimorphic phenotypes. The genetic analysis of the intersex (ix) gene presented here demonstrates that ix is such a terminally positioned regulatory locus. The ix locus has been localized to the cytogenetic interval between 47E3-6 and 47F11-18. A comparison of the morphological and behavioral phenotypes of homozygotes and hemizygotes for three point mutations at ix indicates that the null phenotype of ix is to transform diplo-X animals into intersexes while leaving haplo-X animals unaffected. Analysis of X-ray induced, mitotic recombination clones lacking ix+ function in the abdomen of diplo-X individuals indicates that the ix+ product functions in a cell-autonomous manner and that it is required at least until the termination of cell division in this tissue. Taken together with previous analyses, our results indicate that the ix+ product is required to function with the female-specific product of doublesex to implement appropriate female sexual differentiation in diplo-X animals.

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A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila melanogaster.

Genetics ◽

10.1093/genetics/136.1.195 ◽

1994 ◽

Vol 136 (1) ◽

pp. 195-207

Author(s):

M A Pultz ◽

G S Carson ◽

B S Baker

Keyword(s):

Drosophila Melanogaster ◽

Genetic Analysis ◽

Sex Determination ◽

Temperature Sensitivity ◽

Sexual Differentiation ◽

Regulatory Genes ◽

Temperature Sensitive ◽

Partial Loss ◽

Female Progeny ◽

Regulatory Cascade

Abstract Sex determination in Drosophila is controlled by a cascade of regulatory genes. Here we describe hermaphrodite (her), a new component of this regulatory cascade with pleiotropic zygotic and maternal functions. Zygotically, her+ function is required for female sexual differentiation: when zygotic her+ function is lacking, females are transformed to intersexes. Zygotic her+ function may also play a role in male sexual differentiation. Maternally, her+ function is needed to ensure the viability of female progeny: a partial loss of her+ function preferentially kills daughters. In addition, her has both zygotic and maternal functions required for viability in both sexes. Temperature sensitivity prevails for all known her alleles and for all of the her phenotypes described above, suggesting that her may participate in an intrinsically temperature-sensitive process. This analysis of four her alleles also indicates that the zygotic and maternal components of of her function are differentially mutable. We have localized her cytologically to 36A3-36A11.

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Influence of the brain sexual differentiation process on despair and antidepressant-like effect of fluoxetine in the rat forced swim test

Neuroscience ◽

10.1016/j.neuroscience.2013.12.035 ◽

2014 ◽

Vol 261 ◽

pp. 11-22 ◽

Cited By ~ 21

Author(s):

M.L. Gómez ◽

L. Martínez-Mota ◽

E. Estrada-Camarena ◽

A. Fernández-Guasti

Keyword(s):

Sexual Differentiation ◽

Forced Swim Test ◽

Differentiation Process ◽

Swim Test ◽

Forced Swim ◽

Brain Sexual Differentiation ◽

The Brain

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Diazepam and progesterone produce sexually dimorphic actions on the rat EEG: role of the neonatal sexual differentiation process

Psychoneuroendocrinology ◽

10.1016/s0306-4530(02)00011-2 ◽

2003 ◽

Vol 28 (1) ◽

pp. 85-100 ◽

Cited By ~ 8

Author(s):

A. Fernández-Guasti ◽

I.Y. del Río Portilla ◽

E. Ugalde ◽

M. Corsi-Cabrera

Keyword(s):

Sexual Differentiation ◽

Sexually Dimorphic ◽

Differentiation Process

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Isolation and Functional Characterization of Two Distinct Sexual-Stage-Specific Promoters of the Human Malaria Parasite Plasmodium falciparum

Molecular and Cellular Biology ◽

10.1128/mcb.19.2.967 ◽

1999 ◽

Vol 19 (2) ◽

pp. 967-978 ◽

Cited By ~ 69

Author(s):

Koen J. Dechering ◽

Anita M. Kaan ◽

Wilfred Mbacham ◽

Dyann F. Wirth ◽

Wijnand Eling ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Sexual Differentiation ◽

Functional Characterization ◽

Malarial Parasite ◽

Mosquito Vector ◽

Differentiation Process ◽

Successful Development ◽

Sexual Stages ◽

Developmental Switches

ABSTRACT Transmission of malaria depends on the successful development of the sexual stages of the parasite within the midgut of the mosquito vector. The differentiation process leading to the production of the sexual stages is delineated by several developmental switches. Arresting the progression through this sexual differentiation pathway would effectively block the spread of the disease. The successful development of such transmission-blocking agents is hampered by the lack of a detailed understanding of the program of gene expression that governs sexual differentiation of the parasite. Here we describe the isolation and functional characterization of the Plasmodium falciparum pfs16 and pfs25 promoters, whose activation marks the developmental switches executed during the sexual differentiation process. We have studied the differential activation of the pfs16 and pfs25 promoters during intraerythrocytic development by transfection of P. falciparum and during gametogenesis and early sporogonic development by transfection of the related malarial parasite P. gallinaceum. Our data indicate that the promoter of thepfs16 gene is activated at the onset of gametocytogenesis, while the activity of the pfs25 promoter is induced following the transition to the mosquito vector. Both promoters have unusual DNA compositions and are extremely A/T rich. We have identified the regions in the pfs16 and pfs25 promoters that are essential for high transcriptional activity. Furthermore, we have identified a DNA-binding protein, termed PAF-1, which activatespfs25 transcription in the mosquito midgut. The data presented here shed the first light on the details of processes of gene regulation in the important human pathogen P. falciparum.

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