scholarly journals GENETIC TESTING DECISIONS IN GESTATIONAL CARRIER PREGNANCIES

2021 ◽  
Vol 116 (3) ◽  
pp. e435
Author(s):  
Melody A. Rasouli ◽  
Hailey E. Roberts ◽  
David N. Jackson
Keyword(s):  
Genetic Testing ◽  
Gestational Carrier

scholarly journals The Time has come: Gestational Carrier and the Use of Pre-implantation Genetic Testing (PGT)

2019 ◽  
pp. 137-143
Author(s):  
John Nulsen ◽  
Daniel Richmond Grow ◽  
Reeva Makhijani
Keyword(s):  
Genetic Testing ◽  
Embryo Transfer ◽  
The United States ◽  
Reproductive Technologies ◽  
Single Embryo Transfer ◽  
Multiple Gestation ◽  
Perinatal Morbidity ◽  
Increased Risk ◽  
Perinatal Risks ◽  
Gestational Carrier

Purpose of review: Gestational carrier reproduction is restricted in much of the industrialized world due to complex ethical issues between the intended parents (IP) and the gestational carrier (GC), as well as safety concerns for the GC. Over 3% of all embryo transfers done in the United States involve GCs. Recent review has revealed high perinatal risks associated with assisted reproductive technologies (ART) for GCs. Compared to spontaneous conception, which the GC is familiar with, GCs using IVF have increased risk for twins and triplets of 20 and 46 fold, respectively. The resultant perinatal mortality rates are increased 4-6 fold. Costs in the first year of life for multiples are 5 to 20 times greater than for singletons. As GC cycles continue to increase, we must develop strategies to reduce perinatal risks for GCs and their offspring.Recent findings: Recent advances in IVF with pre-implantation genetic testing allow detection of euploidy for all 24 chromosomes. Elective single embryo transfer has reduced the risk of multiple pregnancy, preterm delivery and perinatal morbidity for women across the age spectrum.Summary: Elective euploid single embryo transfer, through the use of PGT, allows for very high pregnancy rates while reducing perinatal morbidity to natural levels. Both multiple gestation and miscarriage are dramatically reduced. Implementation of this technology in GCs will greatly enhance the safety of pregnancies, protecting this vulnerable population of altruistic women.

scholarly journals Impact of preimplantation genetic testing for aneuploidy (PGT-A) on gestational carrier (GC) cycles in the United States

2019 ◽  
Vol 112 (3) ◽  
pp. e227
Author(s):  
Reeva B. Makhijani ◽  
Madeline Coulter ◽  
Jeffrey Thorne ◽  
Chantal Bartels ◽  
John Nulsen ◽  
...  
Keyword(s):  
United States ◽  
Genetic Testing ◽  
The United States ◽  
Preimplantation Genetic Testing ◽  
Gestational Carrier

Genetic Testing Goes Commercial

2009 ◽  
Vol 40 (12) ◽  
pp. 12 ◽  
Author(s):  
HOWARD P. LEVY
Keyword(s):  
Genetic Testing

p16 Genetic Testing Has Limited Impact

2007 ◽  
Vol 38 (11) ◽  
pp. 1-23
Author(s):  
BETSY BATES
Keyword(s):  
Genetic Testing ◽  
Limited Impact
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