Carotenoids inhibit lipid peroxidation induced by tert-butyl hydroperoxide, but not the depletion of glutathione induced by peroxyl radicals in human erythrocytes

2013 ◽  
Vol 65 ◽  
pp. S30
Author(s):  
R.C. Chisté ◽  
M. Freitas ◽  
A.Z. Mercadante ◽  
E. Fernandes
Keyword(s):  
Lipid Peroxidation ◽  
Human Erythrocytes ◽  
Peroxyl Radicals ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Inhibit Lipid Peroxidation

scholarly journals tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans

2020 ◽  
Vol 21 (22) ◽  
pp. 8688
Author(s):  
Hung-Chi Yang ◽  
Hsiang Yu ◽  
Tian-Hsiang Ma ◽  
Wen-Ye Tjong ◽  
Arnold Stern ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
G6pd Deficiency ◽  
Short Term ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
C Elegans ◽  
Tert Butyl Hydroperoxide ◽  
Calcium Independent Phospholipase A2 ◽  
Glucose 6 Phosphate Dehydrogenase

G6PD is required for embryonic development in animals, as severe G6PD deficiency is lethal to mice, zebrafish and nematode. Lipid peroxidation is linked to membrane-associated embryonic defects in Caenorhabditis elegans (C. elegans). However, the direct link between lipid peroxidation and embryonic lethality has not been established. The aim of this study was to delineate the role of lipid peroxidation in gspd-1-knockdown (ortholog of g6pd) C. elegans during reproduction. tert-butyl hydroperoxide (tBHP) was used as an exogenous inducer. Short-term tBHP administration reduced brood size and enhanced germ cell death in C. elegans. The altered phenotypes caused by tBHP resembled GSPD-1 deficiency in C. elegans. Mechanistically, tBHP-induced malondialdehyde (MDA) production and stimulated calcium-independent phospholipase A2 (iPLA) activity, leading to disturbed oogenesis and embryogenesis. The current study provides strong evidence to support the notion that enhanced lipid peroxidation in G6PD deficiency promotes death of germ cells and impairs embryogenesis in C. elegans.

Effect of vitamin C, deferoxamine, quercetin and rutin against tert-butyl hydroperoxide oxidative damage in human erythrocytes

Hematology ◽  
2009 ◽  
Vol 14 (3) ◽  
pp. 168-172 ◽  
Author(s):  
Daniel Witchmichen Krukoski ◽  
Samuel Ricardo Comar ◽  
Ligia Maria Claro ◽  
Maria Suely Soares Leonart ◽  
Aguinaldo José do Nascimento
Keyword(s):  
Vitamin C ◽  
Oxidative Damage ◽  
Human Erythrocytes ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Photoelectron spectroscopy, gas phase acidity, and thermochemistry of tert-butyl hydroperoxide: Mechanisms for the rearrangement of peroxyl radicals

1998 ◽  
Vol 109 (23) ◽  
pp. 10293-10310 ◽  
Author(s):  
Eileen P. Clifford ◽  
Paul G. Wenthold ◽  
Roustam Gareyev ◽  
W. Carl Lineberger ◽  
Charles H. DePuy ◽  
...  
Keyword(s):  
Gas Phase ◽  
Photoelectron Spectroscopy ◽  
Peroxyl Radicals ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Gas Phase Acidity ◽  
Tert Butyl Hydroperoxide
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