Genetic Inactivation of the Phospholipase A 2 Activity of Prdx6 Ameliorates Sepsis-induced Acute Lung Injury

2017 ◽  
Vol 112 ◽  
pp. 208-209
Author(s):  
Jose Pablo Vazquez-Medina ◽  
Jian-Quin Tao ◽  
Priyal Patel ◽  
Renata Bannitz-Fernandes ◽  
Chandra Dodia ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Phospholipase A ◽  
Genetic Inactivation ◽  
Phospholipase A 2

scholarly journals The serpentine path to a novel mechanism-based inhibitor of acute inflammatory lung injury

2014 ◽  
Vol 116 (12) ◽  
pp. 1521-1530 ◽  
Author(s):  
Aron B. Fisher
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Oxidant Stress ◽  
Lung Surfactant ◽  
Phospholipase A ◽  
Peroxiredoxin 6 ◽  
The Past ◽  
Research Activities ◽  
Novel Target ◽  
Nadph Oxidase Activation

The Comroe lecture on which this review is based described my research path during the past 45 years, beginning with studies of oxidant stress (hyperoxia) and eventuating in the discovery of a synthetic inhibitor of phospholipase A2activity (called MJ33) that prevents acute lung injury in mice exposed to lipopolysaccharide. In between were studies of lung ischemia, lung surfactant metabolism, the protein peroxiredoxin 6 and its phospholipase A2activity, and mechanisms for NADPH oxidase activation. These seemingly unrelated research activities provided the nexus for identification of a novel target and a potentially novel therapeutic agent for prevention or treatment of acute lung injury.

scholarly journals Potential role of Clara cell protein, an endogenous phospholipase A2 inhibitor, in acute lung injury

1995 ◽  
Vol 8 (10) ◽  
pp. 1647-1653 ◽  
Author(s):  
P.G. Jorens ◽  
Y. Sibille ◽  
N.J. Goulding ◽  
F.J. van Overveld ◽  
A.G. Herman ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Potential Role ◽  
Phospholipase A ◽  
Clara Cell ◽  
Cell Protein ◽  
Clara Cell Protein
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