Corrigendum to “Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis” [Free Radic. Biol. Med. 52(9) (2012) 1918–1928]

2018 ◽  
Vol 129 ◽  
pp. 621-622
Author(s):  
Ludwig K. Groebler ◽  
Xiao Suo Wang ◽  
Hyun Bo Kim ◽  
Anu Shanu ◽  
Farjaneh Hossain ◽  
...  
Keyword(s):  
Animal Model ◽  
Vitamin C ◽  
Oxidative Damage ◽  
Renal Injury ◽  
Vascular Function ◽  
Acute Renal Injury ◽  
Free Radic Biol

scholarly journals PS-240 Developing A Toxic Paediatric Animal Model Of Non-oliguric Acute Renal Injury With Cisplatin: Abstract PS-240 Table 1

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A199.3-A200
Author(s):  
MJ Santiago ◽  
J López-Herce ◽  
J López ◽  
J Urbano ◽  
R González ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Injury ◽  
Acute Renal Injury

scholarly journals Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Liu Tongqiang ◽  
Liu Shaopeng ◽  
Yu Xiaofang ◽  
Song Nana ◽  
Xu Xialian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Contrast Media ◽  
Renal Injury ◽  
Salvianolic Acid B ◽  
Pi3k Inhibitor ◽  
Iodinated Contrast Media ◽  
Acute Renal Injury ◽  
Nrf2 Pathway ◽  
Salvianolic Acid ◽  
Iodinated Contrast

Contrast-induced acute renal injury (CI-AKI) has become a common cause of hospital-acquired renal failure. However, the development of prophylaxis strategies and approved therapies for CI-AKI is limited. Salvianolic acid B (SB) can treat cardiovascular-related diseases. The aim of the present study was to assess the effect of SB on prevention of CI-AKI and explore its underlying mechanisms. We examined its effectiveness of preventing renal injury in a novel CI-AKI rat model. Compared with saline, intravenous SB pretreatment significantly attenuated elevations in serum creatinine and the histological changes of renal tubular injuries, reduced the number of apoptosis-positive tubular cells, activated Nrf2, and lowered the levels of renal oxidative stress induced by iodinated contrast media. The above renoprotection of SB was abolished by the PI3K inhibitor (wortmannin). In HK-2 cells, SB activated Nrf2 and decreased the levels of oxidative stress induced by hydrogen peroxide and subsequently improved cell viability. The above cytoprotection of SB was blocked by the PI3K inhibitor (wortmannin) or siNrf2. Thus, our results demonstrate that, due to its antioxidant properties, SB has the potential to effectively prevent CI-AKI via the PI3K/Akt/Nrf2 pathway.

scholarly journals Acute Renal Injury and Dysfunction Following Elective Abdominal Aortic Surgery

2007 ◽  
Vol 33 (5) ◽  
pp. 550-555 ◽  
Author(s):  
M. Tallgren ◽  
T. Niemi ◽  
R. Pöyhiä ◽  
E. Raininko ◽  
M. Railo ◽  
...  
Keyword(s):  
Renal Injury ◽  
Aortic Surgery ◽  
Acute Renal Injury ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic
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