Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage

2019 ◽  
Vol 134 ◽  
pp. 527-544 ◽  
Author(s):  
Anees Rahman ◽  
Siraj Pallichankandy ◽  
Faisal Thayyullathil ◽  
Sehamuddin Galadari
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Critical Role ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Ceramide Generation

Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells

2009 ◽  
Vol 7 (11) ◽  
pp. 1745-1755 ◽  
Author(s):  
Geraldine Gueron ◽  
Adriana De Siervi ◽  
Mercedes Ferrando ◽  
Marcelo Salierno ◽  
Paola De Luca ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Critical Role ◽  
Heme Oxygenase 1 ◽  
Prostate Cancer Cells ◽  
Invasive Potential

scholarly journals Calcitriol-Induced Apoptosis in LNCaP Cells Is Blocked By Overexpression of Bcl-21

Endocrinology ◽  
2000 ◽  
Vol 141 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Sarah E. Blutt ◽  
Timothy J. McDonnell ◽  
Tara C. Polek ◽  
Nancy L. Weigel
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Vitamin D ◽  
Cancer Cells ◽  
Mineral Metabolism ◽  
Lncap Cells ◽  
Prostate Cancer Cells ◽  
Apoptotic Pathway ◽  
Induced Apoptosis

Abstract While the role of vitamin D in bone and mineral metabolism has been investigated extensively, the role of the vitamin D receptor in other tissues is less well understood. 1,25-dihydroxyvitamin D3 (calcitriol) can act as a differentiating agent in normal tissues and can inhibit the growth of many cancer cell lines including LNCaP prostate cancer cells. We have shown previously that calcitriol causes LNCaP cell accumulation in the G0/G1 phase of the cell cycle. In this study, we demonstrate that calcitriol also induces apoptosis of LNCaP cells. The calcitriol-induced apoptosis is accompanied by a down-regulation of Bcl-2 and Bcl-XL proteins, both of which protect cells from undergoing apoptosis. Other proteins important in apoptotic control, Bax, Mcl-1, and Bcl-Xs, are unaffected by calcitriol treatment. We find that overexpression of Bcl-2 blocks calcitriol-induced apoptosis and reduces, but does not eliminate, calcitriol-induced growth inhibition. We conclude that both regulation of cell cycle and the apoptotic pathway are involved in calcitriol action in prostate cancer cells.

scholarly journals Role of Bax in quercetin-induced apoptosis in human prostate cancer cells

2008 ◽  
Vol 75 (12) ◽  
pp. 2345-2355 ◽  
Author(s):  
Dae-Hee Lee ◽  
Miroslaw Szczepanski ◽  
Yong J. Lee
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis

scholarly journals Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis

Oncotarget ◽  
2014 ◽  
Vol 5 (14) ◽  
pp. 5624-5636 ◽  
Author(s):  
Eun Ah Shin ◽  
Eun Jung Sohn ◽  
Gunho Won ◽  
Jeong-Un Choi ◽  
Myongsuk Jeong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Critical Role ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Prostate Cancer Cells ◽  
Tanshinone I ◽  
Induced Apoptosis

Desipramine-induced apoptosis in human PC3 prostate cancer cells: Activation of JNK kinase and caspase-3 pathways and a protective role of [Ca2+]i elevation

Toxicology ◽  
2008 ◽  
Vol 250 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Hong-Chiang Chang ◽  
Chorng-Chih Huang ◽  
Chun-Jen Huang ◽  
Jin-Shiung Cheng ◽  
Shiuh-In Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Protective Role ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis
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