Mitochondria as a therapeutic target for ischemic stroke

2020 ◽  
Vol 146 ◽  
pp. 45-58 ◽  
Author(s):  
Zhi He ◽  
Niya Ning ◽  
Qiongxiu Zhou ◽  
Seyed Esmaeil Khoshnam ◽  
Maryam Farzaneh
Keyword(s):  
Ischemic Stroke ◽  
Therapeutic Target

Inflammation as a Therapeutic Target in Acute Ischemic Stroke Treatment

2009 ◽  
Vol 9 (14) ◽  
pp. 1240-1260 ◽  
Author(s):  
Antonino Tuttolomondo ◽  
Riccardo Di Sciacca ◽  
Domenico Di Raimondo ◽  
Chiara Renda ◽  
Antonio Pinto ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Target ◽  
Stroke Treatment

PPAR-γ: therapeutic target for ischemic stroke

2007 ◽  
Vol 28 (5) ◽  
pp. 244-249 ◽  
Author(s):  
Juraj Culman ◽  
Yi Zhao ◽  
Peter Gohlke ◽  
Thomas Herdegen
Keyword(s):  
Ischemic Stroke ◽  
Therapeutic Target ◽  
Ppar Γ

Neuron Protection as a Therapeutic Target in Acute Ischemic Stroke

2009 ◽  
Vol 9 (14) ◽  
pp. 1317-1334 ◽  
Author(s):  
Antonino Tuttolomondo ◽  
Riccardo Di Sciacca ◽  
Domenico Di Raimondo ◽  
Valentina Arnao ◽  
Chiara Renda ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Target

scholarly journals Detrimental and Beneficial Effect of Autophagy and a Potential Therapeutic Target after Ischemic Stroke

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Meng Wang ◽  
Hangil Lee ◽  
Kenneth Elkin ◽  
Redina Bardhi ◽  
Longfei Guan ◽  
...  
Keyword(s):  
Cell Death ◽  
Ischemic Stroke ◽  
Therapeutic Target ◽  
Ischemic Injury ◽  
Potential Therapeutic Target ◽  
Physiologic Mechanism ◽  
Promote Cell Survival ◽  
Cellular Components ◽  
Neuroprotective Therapies

Autophagy, a physiologic mechanism that promotes energy recycling and orderly degradation through self-regulated disassembly of cellular components, helps maintain homeostasis. A series of evidences suggest that autophagy is activated as a response to ischemia and has been well-characterized as a therapeutic target. However, the role of autophagy after ischemia remains controversial. Activated-autophagy can remove necrotic substances against ischemic injury to promote cell survival. On the contrary, activation of autophagy may further aggravate ischemic injury, causing cell death. Therefore, the present review will examine the current understanding of the precise mechanism and role of autophagy in ischemia and recent neuroprotective therapies on autophagy, drug therapies, and nondrug therapies, including electroacupuncture (EA).

Kv1.3 Lymphocyte Potassium Channel Inhibition as a Potential Novel Therapeutic Target in Acute Ischemic Stroke

2014 ◽  
Vol 13 (5) ◽  
pp. 801-806 ◽  
Author(s):  
Andras Folyovich ◽  
Eniko Biro ◽  
Csaba Orban ◽  
Anna Bajnok ◽  
Barna Vasarhelyi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Potassium Channel ◽  
Acute Ischemic Stroke ◽  
Therapeutic Target ◽  
Channel Inhibition ◽  
Novel Therapeutic

C1q/TNF‐related protein 9: A novel therapeutic target in ischemic stroke?

2018 ◽  
Vol 97 (2) ◽  
pp. 128-136 ◽  
Author(s):  
Cui Yang ◽  
Fan Fan ◽  
Darrell Sawmiller ◽  
Jun Tan ◽  
Qingsong Wang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Therapeutic Target ◽  
Related Protein ◽  
Novel Therapeutic

scholarly journals Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies

2017 ◽  
Vol 38 ◽  
pp. 39-48 ◽  
Author(s):  
Joakim N.E. Ölmestig ◽  
Ida R. Marlet ◽  
Atticus H. Hainsworth ◽  
Christina Kruuse
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Therapeutic Target ◽  
Preclinical Studies ◽  
Phosphodiesterase 5
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