scholarly journals Heat Shock Protein 27 (HSP27) As a Therapeutic Target in Ischemic Stroke and Neurodegenerative Disorders

2017 ◽  
Vol 63 (1) ◽  
pp. 17-21 ◽  
Author(s):  
HIDEKI SHIMURA ◽  
RYOTA TANAKA ◽  
TAKAO URABE ◽  
NOBUTAKA HATTORI
Keyword(s):  
Ischemic Stroke ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Neurodegenerative Disorders ◽  
Therapeutic Target ◽  
Heat Shock Protein 27

scholarly journals Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target

2012 ◽  
Vol 5 (1) ◽  
pp. 7 ◽  
Author(s):  
Aparna Vidyasagar ◽  
Nancy A Wilson ◽  
Arjang Djamali
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Therapeutic Target ◽  
Heat Shock Protein 27

scholarly journals Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma

2009 ◽  
Vol 17 (8) ◽  
pp. 1387-1394 ◽  
Author(s):  
Elie Hadchity ◽  
Marie-Thérèse Aloy ◽  
Christian Paulin ◽  
Emma Armandy ◽  
Emmanuel Watkin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Heat Shock Protein 27 ◽  
Neck Squamous Cell Carcinoma ◽  
Radiation Sensitization

Heat shock protein 27 as a neuroprotective biomarker and a suitable target for stem cell therapy and pharmacotherapy in ischemic stroke

2019 ◽  
Vol 44 (2) ◽  
pp. 356-367 ◽  
Author(s):  
Marjan Behdarvandy ◽  
Mohammad Karimian ◽  
Mohammad Ali Atlasi ◽  
Abolfazl Azami Tameh
Keyword(s):  
Stem Cell ◽  
Ischemic Stroke ◽  
Heat Shock ◽  
Cell Therapy ◽  
Heat Shock Protein ◽  
Stem Cell Therapy ◽  
Heat Shock Protein 27 ◽  
Suitable Target

scholarly journals Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury

2017 ◽  
Vol 114 (7) ◽  
pp. E1243-E1252 ◽  
Author(s):  
Yejie Shi ◽  
Xiaoyan Jiang ◽  
Lili Zhang ◽  
Hongjian Pu ◽  
Xiaoming Hu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Injury ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Blood Brain Barrier ◽  
Actin Polymerization ◽  
Heat Shock Protein 27 ◽  
Brain Barrier ◽  
Blood Brain ◽  
Neurological Conditions

The damage borne by the endothelial cells (ECs) forming the blood–brain barrier (BBB) during ischemic stroke and other neurological conditions disrupts the structure and function of the neurovascular unit and contributes to poor patient outcomes. We recently reported that structural aberrations in brain microvascular ECs—namely, uncontrolled actin polymerization and subsequent disassembly of junctional proteins, are a possible cause of the early onset BBB breach that arises within 30–60 min of reperfusion after transient focal ischemia. Here, we investigated the role of heat shock protein 27 (HSP27) as a direct inhibitor of actin polymerization and protectant against BBB disruption after ischemia/reperfusion (I/R). Using in vivo and in vitro models, we found that targeted overexpression of HSP27 specifically within ECs—but not within neurons—ameliorated BBB impairment 1–24 h after I/R. Mechanistically, HSP27 suppressed I/R-induced aberrant actin polymerization, stress fiber formation, and junctional protein translocation in brain microvascular ECs, independent of its protective actions against cell death. By preserving BBB integrity after I/R, EC-targeted HSP27 overexpression attenuated the infiltration of potentially destructive neutrophils and macrophages into brain parenchyma, thereby improving long-term stroke outcome. Notably, early poststroke administration of HSP27 attached to a cell-penetrating transduction domain (TAT-HSP27) rapidly elevated HSP27 levels in brain microvessels and ameliorated I/R-induced BBB disruption and subsequent neurological deficits. Thus, the present study demonstrates that HSP27 can function at the EC level to preserve BBB integrity after I/R brain injury. HSP27 may be a therapeutic agent for ischemic stroke and other neurological conditions involving BBB breakdown.

scholarly journals Serum Heat Shock Protein 27 Levels Represent a Potential Therapeutic Target for Atherosclerosis

2013 ◽  
Vol 62 (16) ◽  
pp. 1446-1454 ◽  
Author(s):  
Tara A. Seibert ◽  
Benjamin Hibbert ◽  
Yong-Xiang Chen ◽  
Katey Rayner ◽  
Trevor Simard ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Therapeutic Target ◽  
Heat Shock Protein 27 ◽  
Potential Therapeutic Target

scholarly journals Serum levels of heat shock protein 27 in patients with acute ischemic stroke

2013 ◽  
Vol 18 (4) ◽  
pp. 531-533 ◽  
Author(s):  
Gabriella Gruden ◽  
Federica Barutta ◽  
Irene Catto ◽  
Giovanni Bosco ◽  
Maria Giovanna Caprioli ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Acute Ischemic Stroke ◽  
Serum Levels ◽  
Heat Shock Protein 27

765: Modified Expression of Heat Shock Protein 27 in Renal Cell Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 203-203
Author(s):  
Cecilia Sarto ◽  
Paolo Favini ◽  
Cristina Valsecchi ◽  
Stefano Casellato ◽  
Fulvio Magni ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Heat Shock Protein 27

Protektive Wirkung von Heat Shock Protein 27 in der Magenmukosa

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
M Ebert ◽  
C Schäfer ◽  
J Hoffmann ◽  
C Kubisch ◽  
G Treiber ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Protektive Wirkung
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