Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL–induced retinal pigment epithelial cell death as a potential pharmacotherapy

2021 ◽  
Author(s):  
Gopalan Gnanaguru ◽  
Ashley Mackey ◽  
Eun Young Choi ◽  
Anthoula Arta ◽  
Franco Aparecido Rossato ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment Epithelial Cell ◽  
Retinal Pigment ◽  
Phenol Compounds ◽  
Pigment Epithelial ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Epithelial Cell Death

scholarly journals Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARγAgonist, 15-Deoxy-Delta 12, 14-ProstaglandinJ2

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Jason Y. Chang ◽  
Puran S. Bora ◽  
Nalini S. Bora
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment Epithelial Cell ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Experimental Conditions ◽  
Pigment Epithelial ◽  
Age Related ◽  
Epithelial Cell Death

Cellular oxidative stress plays an important role in retinal pigment epithelial (RPE) cell death during aging and the development of age-related macular degeneration. Early reports indicate that during phagocytosis of rod outer segments, there is an increase of RPE oxidative stress and an upregulation of PPARγmRNA in these cells. These studies suggest that activation of PPARγmay modulate cellular oxidative stress. This paper presents a brief review of recent studies that investigate RPE oxidative stress under various experimental conditions. This is followed by a detailed review on those reports that examine the protective effect of the natural PPARγligand, 15d-PGJ2, against RPE oxidative stress. This agent can upregulate glutathione and prevent oxidant-induced intracellular reactive oxygen species accumulation, mitochondrial depolarization, and apoptosis. The cytoprotective effect of this agent, however, is not shared by other PPARγagonists. Nonetheless, this property of 15d-PGJ2may be useful in future development of pharmacological tools against retinal diseases caused by oxidative stress.

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