Tris(Imidazolyl) Dicopper(I) Complex and its Reactivity to Exert Catalytic Oxidation of Sterically Hindered Phenol Substrates via a [Cu2O]2+ Core

The Cu ion ligated with histidine residues is a common active site motif of various Cu-containing metalloenzymes exerting versatile catalytic oxidation reactions. Due to the scarce of structurally characterized biomimetic...

SYNTHESIS, CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF NEW 1,3-DIMETHYL-8-(CHROMON-3-YL)-XANTHINE DERIVATIVES CONTAINING 2,6-DI-TERT-BUTYLPHENOL FRAGMENT

The condensation of 3-formylchromones and 6-amino-5-((3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino)-1,3-dimethyl-pyrimidine-2,4(1H,3H)-dione allowed us to synthesize chromone based hybrids containing additional pharmacophores - xanthine and sterically hindered phenol fragments. Novel compounds have been characterized by 1H...

5-Aryl-2-(3,5-dialkyl-4-hydroxyphenyl)-4,4-dimethyl-4H-imidazole 3-Oxides and Their Redox Species: How Antioxidant Activity of 1-Hydroxy-2,5-dihydro-1H-imidazoles Correlates with the Stability of Hybrid Phenoxyl–Nitroxides

Cyclic nitrones of the imidazole series, containing a sterically hindered phenol group, are promising objects for studying antioxidant activity; on the other hand, they can form persistent hybrid phenoxyl–nitroxyl radicals (HPNs) upon oxidation. Here, a series of 5-aryl-4,4-dimethyl-4H-imidazole 3-oxides was obtained by condensation of aromatic 2-hydroxylaminoketones with 4-formyl-2,6-dialkylphenols followed by oxidation of the initially formed N-hydroxy derivatives. It was shown that the antioxidant activity of both 1-hydroxy-2,5-dihydroimidazoles and 4H-imidazole 3-oxides increases with a decrease in steric volume of the alkyl substituent in the phenol group, while the stability of the corresponding HPNs generated from 4H-imidazole 3-oxides reveals the opposite tendency.

Bi-functional sterically hindered phenol lipid-based delivery systems as potential multi-target agents against Alzheimer's disease via an intranasal route

New lipid-based nanomaterials based on sterically hindered phenols were developed as potential drugs against Alzheimer's disease via intranasal administration.