Y chromosome microsatellite genetic variation in two Native American populations from Argentina: Population stratification and mutation data

2008 ◽  
Vol 2 (4) ◽  
pp. 274-280 ◽  
Author(s):  
Ulises Toscanini ◽  
Leonor Gusmão ◽  
Gabriela Berardi ◽  
António Amorim ◽  
Ángel Carracedo ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Native American ◽  
Y Chromosome ◽  
Population Stratification ◽  
Mutation Data

scholarly journals Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rossana Santiago de Sousa Azulay ◽  
Luís Cristóvão Porto ◽  
Dayse Aparecida Silva ◽  
Maria da Glória Tavares ◽  
Roberta Maria Duailibe Ferreira Reis ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Native American ◽  
Y Chromosome ◽  
Chromosome Analysis ◽  
Brazilian Population ◽  
Genetic Ancestry ◽  
Sample Sizes ◽  
Chromosome Markers ◽  
Hla Genotypes

AbstractThis study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and DRB1*04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1*03 and DRB1*04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.

Y-chromosome genetic variation in Rio De Janeiro population

2006 ◽  
Vol 18 (6) ◽  
pp. 829-837 ◽  
Author(s):  
Dayse A. Silva ◽  
Elizeu Carvalho ◽  
Guilherme Costa ◽  
Lígia Tavares ◽  
António Amorim ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Y Chromosome ◽  
Rio De Janeiro

scholarly journals Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders

2019 ◽  
Vol 29 (1) ◽  
pp. 149-157.e3 ◽  
Author(s):  
Thomaz Pinotti ◽  
Anders Bergström ◽  
Maria Geppert ◽  
Matt Bawn ◽  
Dominique Ohasi ◽  
...  
Keyword(s):  
Population Structure ◽  
Native American ◽  
Y Chromosome ◽  
Rapid Expansion

scholarly journals History of Click-Speaking Populations of Africa Inferred from mtDNA and Y Chromosome Genetic Variation

2007 ◽  
Vol 24 (10) ◽  
pp. 2180-2195 ◽  
Author(s):  
S. A. Tishkoff ◽  
M. K. Gonder ◽  
B. M. Henn ◽  
H. Mortensen ◽  
A. Knight ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Y Chromosome ◽  
History Of

scholarly journals The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1273
Author(s):  
Katherine Parker ◽  
A. Mesut Erzurumluoglu ◽  
Santiago Rodriguez
Keyword(s):  
Population Genetics ◽  
Genetic Variation ◽  
Y Chromosome ◽  
Complex Traits ◽  
Association Studies ◽  
Epidemiological Studies ◽  
Complex Locus ◽  
Complex Human Traits ◽  
Human Complex ◽  
Human Y Chromosome

The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.

scholarly journals Genetic variation of goat Y chromosome in the Sardinian population

2009 ◽  
Vol 8 (sup2) ◽  
pp. 159-161 ◽  
Author(s):  
Tiziana Sechi ◽  
Sabrina Miari ◽  
Daniela Piras ◽  
Lia Crasta ◽  
Giuliana Mulas ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Y Chromosome ◽  
Sardinian Population

Association between genetic variation in the Y chromosome and hypertension in myocardial infarction patients

2003 ◽  
Vol 122A (3) ◽  
pp. 234-237 ◽  
Author(s):  
Eliecer Coto García ◽  
Pelayo González ◽  
Mónica G. Castro ◽  
Ruth Alvarez ◽  
Julián R. Reguero ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Genetic Variation ◽  
Y Chromosome

scholarly journals Genetic variation in South Indian castes: evidence from Y-chromosome, mitochondrial, and autosomal polymorphisms

BMC Genetics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 86 ◽  
Author(s):  
W.s. Watkins ◽  
R. Thara ◽  
B.j. Mowry ◽  
Y. Zhang ◽  
D.j. Witherspoon ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Y Chromosome ◽  
South Indian

scholarly journals Genetic Variation Within Two Sympatric Spotted Gum Eucalypts Exceeds Between Taxa Variation

2008 ◽  
Vol 57 (1-6) ◽  
pp. 249-256 ◽  
Author(s):  
J. W. Ochieng ◽  
M. Shepherd ◽  
P. R. Baverstock ◽  
G. Nikles ◽  
D. J. Lee ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Allele Frequency ◽  
Population Stratification ◽  
East Coast ◽  
Population Substructure ◽  
Cherry Tree ◽  
Separate Species ◽  
Intermediate Morphology ◽  
Species Specific ◽  
A Site

AbstractPopulation substructure and hybridization, among other factors, have the potential to cause erroneous associations in linkage disequilibrium (LD) mapping. Two closely related spotted gum eucalypts, Corymbia variegata and C. henryi (Myrtaceae) occur in sympatry in the east coast of Australia and potentially interbreed. They are morphologically similar but are distinguished as separate species based on capsule and foliage size. To determine whether they hybridize in nature and its implications for LD mapping, we investigated the level of molecular divergence between the two species at two sympatric locations separated by 300 kilometres. Very few individuals of intermediate morphology were identified, despite the two species occurring only metres apart. Analysis of genetic structure using 12 microsatellite loci showed that genetic differentiation between populations of the same species at different locations (FST= 0.07 for both species; p = 0.0001) was significantly higher than that observed between species at each location (mean FST= 0.02 and 0.04 for Cherry tree and Bunyaville respectively; p = 0.0001; all Mann-Whitney U-test p ≤ 0.01). No species-specific alleles or significant allele frequency differences were detected within a site, suggesting recurr#ent local gene flow between the two species. The lack of significant allele frequency differences implies no population stratification along taxonomic lines. This suggested that there is little concern for cryptic hybridization when sampling from sites of sympatry for LD mapping.

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