Q1a3a native-American Y-haplogroup detection in DNA quantification step: A quick diagnosis for Y-chromosome database selection

AbstractThis study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and DRB1*04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1*03 and DRB1*04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.

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Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders

Current Biology ◽

10.1016/j.cub.2018.11.029 ◽

2019 ◽

Vol 29 (1) ◽

pp. 149-157.e3 ◽

Cited By ~ 21

Author(s):

Thomaz Pinotti ◽

Anders Bergström ◽

Maria Geppert ◽

Matt Bawn ◽

Dominique Ohasi ◽

...

Keyword(s):

Population Structure ◽

Native American ◽

Y Chromosome ◽

Rapid Expansion

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Characterization of the AZF region of the Y chromosome in Native American haplogroup Q

Journal of Science Humanities and Arts - JOSHA ◽

10.17160/josha.3.4.219 ◽

2016 ◽

Vol 3 (4) ◽

Author(s):

Evguenia Alechine ◽

Werner Schempp ◽

Daniel Corach

Keyword(s):

Native American ◽

Y Chromosome ◽

Haplogroup Q ◽

Azf Region

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Y-chromosome biallelic polymorphisms and Native American population structure

Annals of Human Genetics ◽

10.1046/j.1469-1809.2002.00114.x ◽

2002 ◽

Vol 66 (4) ◽

pp. 255-259 ◽

Cited By ~ 32

Author(s):

M.-C. BORTOLINI ◽

F. M. SALZANO ◽

C. H. D. BAU ◽

Z. LAYRISSE ◽

M. L. PETZL-ERLER ◽

...

Keyword(s):

Population Structure ◽

Native American ◽

Y Chromosome ◽

American Population ◽

Native American Population

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Genetic Ancestry Inferred From Autosomal and Y Chromosome Markers and HLA Genotypes in Type 1 Diabetes From an Admixed Brazilian Population.

10.21203/rs.3.rs-262854/v1 ◽

2021 ◽

Author(s):

Rossana Santiago de Sousa Azulay ◽

Luís Cristóvão Porto ◽

Dayse Aparecida Silva ◽

Maria da Gloria Tavares ◽

Roberta Dualibe ◽

...

Keyword(s):

Type 1 Diabetes ◽

Native American ◽

Native Americans ◽

Y Chromosome ◽

Chromosome Analysis ◽

Brazilian Population ◽

Genetic Ancestry ◽

Sample Sizes ◽

Chromosome Markers

Abstract This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1* 03 and DRB1* 04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1* 03 and DRB1* 04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.

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Y chromosome polymorphisms in Native American and Siberian populations: identification of Native American Y chromosome haplotypes

Human Genetics ◽

10.1007/s004390050548 ◽

1997 ◽

Vol 100 (5-6) ◽

pp. 536-543 ◽

Cited By ~ 53

Author(s):

Jeffrey T. Lell ◽

Michael D. Brown ◽

Theodore G. Schurr ◽

R. I. Sukernik ◽

Yelena B. Starikovskaya ◽

...

Keyword(s):

Native American ◽

Y Chromosome

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Y chromosome microsatellite genetic variation in two Native American populations from Argentina: Population stratification and mutation data

Forensic Science International Genetics ◽

10.1016/j.fsigen.2008.03.001 ◽

2008 ◽

Vol 2 (4) ◽

pp. 274-280 ◽

Cited By ~ 27

Author(s):

Ulises Toscanini ◽

Leonor Gusmão ◽

Gabriela Berardi ◽

António Amorim ◽

Ángel Carracedo ◽

...

Keyword(s):

Genetic Variation ◽

Native American ◽

Y Chromosome ◽

Population Stratification ◽

Mutation Data

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Rapid screening for Native American mitochondrial and Y-chromosome haplogroups detection in routine DNA analysis

Forensic Science International Genetics ◽

10.1016/j.fsigen.2010.08.018 ◽

2011 ◽

Vol 5 (2) ◽

pp. 105-108 ◽

Cited By ~ 20

Author(s):

Gala Zuccarelli ◽

Evguenia Alechine ◽

Mariela Caputo ◽

Cecilia Bobillo ◽

Daniel Corach ◽

...

Keyword(s):

Native American ◽

Y Chromosome ◽

Dna Analysis ◽

Rapid Screening

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Molecular Genetic Evidence from Contemporary Populations for the Origins of Native North Americans

10.1093/oxfordhb/9780199766956.013.4 ◽

2016 ◽

Author(s):

Michael Crawford ◽

Rohina C. Rubicz

Keyword(s):

Mitochondrial Dna ◽

Native American ◽

Y Chromosome ◽

Molecular Genetic ◽

Haplotype Diversity ◽

Population Expansion ◽

Genetic Evidence ◽

Whole Genome Sequence ◽

Aleutian Island ◽

Molecular Genetic Evidence

An overview of the current molecular genetic evidence for the origins of North American populations is presented, including specific examples from the authors’ work with the Aleutian Island inhabitants. Shared mitochondrial DNA and Y-chromosome DNA markers among Siberians and Native Americans point to a Pleistocene migration from Siberia into the Americas via Beringia. There was likely a later migration from Siberia to Alaska, based on the analysis of whole-genome sequence data from a Greenland Paleoeskimo that clusters this individual with Siberian populations. Coalescence date estimates for Native American mitochondrial DNA and Y-chromosome DNA haplogroups indicate that there was a population expansion approximately 15,000–18,000 that was associated with a pre-Clovis settlement of the Americas and coastal migration, and then a later expansion of circum-Arctic populations. Settlement of the Aleutian Archipelago took place via east-to-west migration of Aleut kin groups, accompanied by a clinal loss in mitochondrial DNA haplotype diversity.

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