scholarly journals Increased Estrogen Receptor β in Adipose Tissue Is Associated With Increased Intracellular and Reduced Circulating Adiponectin Protein Levels in Aged Female Rats

2011 ◽  
Vol 8 (5) ◽  
pp. 325-333 ◽  
Author(s):  
Nanette J. Tomicek ◽  
Timothy S. Lancaster ◽  
Donna H. Korzick
Keyword(s):  
Estrogen Receptor ◽  
Adipose Tissue ◽  
Estrogen Receptor Β ◽  
Female Rats ◽  
Protein Levels

Selected Contribution: Estrogen receptor-α antisense decreases brain estrogen receptor levels and affects ventilation in male and female rats

2001 ◽  
Vol 91 (4) ◽  
pp. 1886-1892 ◽  
Author(s):  
Shashita R. Inamdar ◽  
Kathleen M. Eyster ◽  
Evelyn H. Schlenker
Keyword(s):  
Estrogen Receptor ◽  
Aspartic Acid ◽  
Estrogen Receptor Α ◽  
Neonatal Rat ◽  
Female Rats ◽  
Antisense Oligodeoxynucleotide ◽  
Protein Levels ◽  
Ventilatory Responses ◽  
Rat Pups ◽  
Male And Female Rats

We hypothesized that administration of an antisense oligodeoxynucleotide (ODN) to estrogen receptor (ER)-α mRNA decreases the ER protein in the neonatal rat brain, alters the sex-specific ventilatory responses to aspartic acid in rats, and counteracts the effects of testosterone proportionate (TP) in females. One-day-old rat pups were injected intraventricularly with vehicle, antisense ER ODN, or scrambled ODN control. Additional groups of females received TP or vehicle and one of the three treatments. Brain ER protein levels were decreased by 65% at 6 h and 35% at 24 h after antisense ODN. Aspartic acid decreased ventilation in all groups of weanling males and females except ER ODN-treated females and TP-vehicle-treated females. Aspartic acid decreased ventilation in all groups of adult females except those given TP and in males. Weanling ER ODN-treated rats were shorter and weighed less than controls. Only adult ER ODN-treated males exhibited these traits. Thus neonatal ER affects aspartic acid modulation of breathing and body growth in a sex-specific and developmental manner.

The ratio of estrogen receptor α to estrogen receptor β in adipose tissue is associated with leptin production and obesity

Steroids ◽  
2007 ◽  
Vol 72 (6-7) ◽  
pp. 592-599 ◽  
Author(s):  
Jung-Ho Shin ◽  
Jun-Young Hur ◽  
Hong Seog Seo ◽  
Yu-A Jeong ◽  
Jae Kwan Lee ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Adipose Tissue ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Β

Identification of Estrogen Receptor β RNA in Human Breast and Abdominal Subcutaneous Adipose Tissue

1998 ◽  
Vol 248 (3) ◽  
pp. 523-526 ◽  
Author(s):  
David L. Crandall ◽  
Dennis E. Busler ◽  
Thomas J. Novak ◽  
Renata V. Weber ◽  
John G. Kral
Keyword(s):  
Estrogen Receptor ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Estrogen Receptor Β ◽  
Human Breast ◽  
Subcutaneous Adipose

scholarly journals Effects of ovariectomy, estrogen and soy isoflavones in rats submandibular glands

2017 ◽  
Vol 20 (3) ◽  
Author(s):  
Luana Marotta Reis Vasconcellos ◽  
Vanessa Ávila Sarmento Silveira ◽  
Raphaela Silveira Medeiros ◽  
Márian Yaktin Amorin ◽  
Yasmin Rodarte Carvalho ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Salivary Glands ◽  
Hormone Replacement ◽  
Soy Isoflavones ◽  
Estrogen Receptor Β ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Nuclear Antigen ◽  
Soy Isoflavone ◽  
Submandibular Glands

<p><strong>Objective</strong>: A decrease in granular convoluted tubule (GCT) cells and acini occurs in the submandibular glands of castrated female rats, while in rats submitted to hormone replacement and phytotherapy with soy isoflavones, this effect is reversed. This study aimed to elucidate the mechanisms through which these changes occur. <strong>Material and Methods</strong>: Rats (n=84) were ovariectomized and 21 were sham-operated. Ovariectomized rats were randomly subdivided and orally administered the following: 17 β-estradiol (OVX-E; n=21), 15 mg/kg/day of soy isoflavone extract (OVX-I; n=21), 17 β-estradiol + soy isoflavone extract (OVX-A; n=21); and water as placebo (OVX; n=21). The rats were euthanized three, five and eight weeks after ovariectomy. The submandibular salivary glands were submitted to histological processing with HE stain and immunohistochemistry was performed using the streptavidin-biotin-peroxidase complex. The cell area and the expression of proliferating cell nuclear antigen and estrogen receptor β were evaluated. <strong>Results</strong>: The results were statistically analyzed by ANOVA and Tukey test. A decrease in the area of GCT cells in the OVX, was observed, in contrast with an increase in the OVX-E. PCNA in the acinar cells and estrogen receptors were elevated in the OVX-I group. <strong>Conclusion</strong>: Castration exerts an immediate reductive effect on the volume of GCT cells. Estrogens, soy isoflavones and their combination have different mechanisms of action on the homeostasis of the gland. Estrogens cause an increase in GCT cells area, while isoflavones enhance cell proliferation and the expression of estrogen receptor-β. Their association showed no additional increase in the effect studied.</p><p><strong>Keywords</strong></p><p>Estrogen; Morphometry; Salivary glands; Soy isoflavones.</p>

scholarly journals Estrus-Cycle Regulation of Cortical Inhibition

2018 ◽  
Author(s):  
Ann M. Clemens ◽  
Constanze Lenschow ◽  
Prateep Beed ◽  
Lanxiang Li ◽  
Rosanna Sammons ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Β ◽  
Cortical Inhibition ◽  
Female Rats ◽  
Estrus Cycle ◽  
Whole Cell ◽  
Fast Spiking ◽  
Whole Cell Recordings

SummaryFemale mammals experience cyclical changes in sexual receptivity known as the estrus-cycle. Little is known about how estrus affects the cortex although alterations in sensation, cognition and the cyclic occurrence of epilepsy suggest brain-wide processing changes. We performedin vivojuxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus-cycle potently altered cortical inhibition. Fast-spiking interneurons strongly varied their activity with the estrus-cycle and estradiol in ovariectomized females, while regular-spiking excitatory neurons did not change.In vivowhole-cell recordings revealed a varying excitation-to-inhibition-ratio with estrus.In situhybridization for estrogen receptor β (Esr2) showed co-localization with parvalbumin-positive interneurons in deep cortical layers, mirroring the laminar distribution of our physiological findings.In vivoandin vitroexperiments confirmed that estrogen acts locally to increase fast-spiking interneuron excitability through an estrogen receptor β mechanism. We conclude that sex hormones powerfully modulate cortical inhibition in the female brain.

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