scholarly journals Sa1892 LINKED COLOR IMAGING REDUCES THE MISS RATE OF NEOPLASTIC LESIONS IN THE RIGHT COLON: A RANDOMIZED TANDEM COLONOSCOPY STUDY

2018 ◽  
Vol 87 (6) ◽  
pp. AB236
Author(s):  
Silvia Paggi ◽  
Giuseppe Mogavero ◽  
Arnaldo Amato ◽  
Alida Andrealli ◽  
Gianni Imperiali ◽  
...  
Keyword(s):  
Right Colon ◽  
Color Imaging ◽  
Neoplastic Lesions ◽  
Linked Color Imaging ◽  
The Right

P.03.10 LINKED COLOR IMAGING (LCI) REDUCES THE MISS RATE OF NEOPLASTIC LESIONS IN THE RIGHT COLON: A RANDOMIZED TANDEM COLONOSCOPY STUDY

2018 ◽  
Vol 50 (2) ◽  
pp. e147
Author(s):  
G. Mogavero ◽  
S. Paggi ◽  
A. Amato ◽  
A. Andrealli ◽  
G. Imperiali ◽  
...  
Keyword(s):  
Right Colon ◽  
Color Imaging ◽  
Neoplastic Lesions ◽  
Linked Color Imaging ◽  
The Right

Linked color imaging reduces the miss rate of neoplastic lesions in the right colon: a randomized tandem colonoscopy study

Endoscopy ◽  
2018 ◽  
Vol 50 (04) ◽  
pp. 396-402 ◽  
Author(s):  
Silvia Paggi ◽  
Giuseppe Mogavero ◽  
Arnaldo Amato ◽  
Emanuele Rondonotti ◽  
Alida Andrealli ◽  
...  
Keyword(s):  
Color Contrast ◽  
Right Colon ◽  
Color Imaging ◽  
Colon Adenoma ◽  
Detection Rates ◽  
Adenoma Detection ◽  
Significant Difference ◽  
Neoplastic Lesions ◽  
Linked Color Imaging ◽  
The Right

Abstract Background Linked color imaging (LCI) is a newly developed image-enhancing endoscopy technology that provides bright endoscopic images and increases color contrast. We investigated whether LCI improves the detection of neoplastic lesions in the right colon when compared with high definition white-light imaging (WLI). Methods Consecutive patients undergoing colonoscopy were randomized (1:1) after cecal intubation into right colon inspection at first pass by LCI or by WLI. At the hepatic flexure, the scope was reintroduced to the cecum under LCI and a second right colon inspection was performed under WLI in previously LCI-scoped patients (LCI–WLI group) and vice versa (WLI–LCI group). Lesions detected on first- and second-pass examinations were used to calculate detection and miss rates, respectively. The primary outcome was the right colon adenoma miss rate. Results Of the 600 patients enrolled, 142 had at least one adenoma in the right colon, with similar right colon adenoma detection rates (r-ADR) in the two groups (22.7 % in LCI–WLI and 24.7 % in WLI–LCI). At per-polyp analysis, double inspection of the right colon in the LCI–WLI and WLI–LCI groups resulted in an 11.8 % and 30.6 % adenoma miss rate, respectively (P < 0.001). No significant difference in miss rate was found for advanced adenomas or sessile serrated lesions. At per-patient analysis, at least one adenoma was identified in the second pass only (incremental ADR) in 2 of 300 patients (0.7 %) in the LCI – WLI group and in 13 of 300 patients (4.3 %) in the WLI – LCI group (P = 0.01). Conclusions LCI could reduce the miss rate of neoplastic lesions in the right colon.

scholarly journals Additional Thirty Seconds Observation with Linked Color Imaging Improves Detection of Missed Polyps in the Right-Sided Colon

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Naohisa Yoshida ◽  
Yutaka Inada ◽  
Ritsu Yasuda ◽  
Takaaki Murakami ◽  
Ryohei Hirose ◽  
...  
Keyword(s):  
Pilot Study ◽  
Detection Rate ◽  
Additional Observation ◽  
Ascending Colon ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Color Imaging ◽  
Linked Color Imaging ◽  
The Right ◽  
White Light Imaging

Background and Aims. Missed polyps are a pitfall of colonoscopy. In this study, we analyzed the efficacy of an additional 30 seconds observation using linked color imaging (LCI) for detecting adenoma and sessile serrated adenoma/polyp (SSA/P). Materials and Methods. We enrolled patients undergoing colonoscopy from February to October 2017 in two institutions. In all patients, the cecum and ascending colon were observed with white light imaging (WLI) first. The colonoscope was inserted again, and the cecum and ascending colon were observed for an additional 30 seconds using either LCI or WLI. The method for the 30 sec observation was to insufflate the cecum and ascending colon sufficiently and observe them in a distant view, because the length of the second observation was determined to be precisely 30 sec. For the second observation, LCI was performed for the first 65 patients and WLI for the next 65. Adenoma and SSA/P detection rate (ASDR) in the second observation were examined in both groups. According to a pilot study, the sample size was estimated 65. Results. In the first observation, ASDR were 30.7% in the LCI group and 32.2% in the WLI group (p=0.85). For the second observation, 13 polyps were detected in the LCI group and 5 polyps in the WLI group (p=0.04). Additionally, ASDR for the second observation were 18.5% and 6.1%, respectively (p=0.03). There were no significant differences between the LCI and WLI groups with respect to morphology (ratio of polypoid) (38.5% versus 60.0%, p=0.52) and histology (ratio of adenoma) (92.3% versus 100.0%, p=0.91). Total adenoma and SSA/P number were 48 in the LCI group and 36 in the WLI group (p=0.02). Conclusion. The 30 seconds additional observation with LCI improved the detection of adenoma and SSA/P in the right-sided colon.

scholarly journals DOP37 Neoplastic lesions outside diseased area in inflammatory bowel disease patients: A national cohort study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S074-S075
Author(s):  
A Cremer ◽  
P Demetter ◽  
M De Vos ◽  
J F Rahier ◽  
F Baert ◽  
...  
Keyword(s):  
Low Grade ◽  
Right Colon ◽  
Disease Area ◽  
Surgical Specimen ◽  
Increased Risk ◽  
Neoplastic Lesions ◽  
National Cohort ◽  
Inflammatory Bowel ◽  
The Right

Abstract Background Patients with inflammatory bowel diseases (IBD) are at increased risk of dysplasia and colitis-associated cancer (CAC). The presentation of (pre)neoplastic lesions (low-grade dysplasia (LGD), high-grade dysplasia (HGD) or colorectal cancer (CRC) is reported to vary depending if the lesions are located inside disease area (IDA) or outside diseased area (ODA). The primary aim was to analyse the characteristics and prognostic of IDA compared with ODA neoplastic lesions in a large cohort of IBD patients. Methods We performed a multicentre retrospective pathological data collection from 7 tertiary referral regional or academic IBD centres in Belgium. Clinical, endoscopic and pathological data were retrieved through retrospective electronic chart review. From the IBD pathology databases, 1183 colorectal lesions were identified in 541 IBD patients: 415 developed dysplasia (77%) and 126 CRC (23%) during their follow-up. Biopsies and surgical specimen were centrally reviewed by an expert IBD pathologist to confirm the diagnosis of dysplasia and/or CRC. Results Demographic and clinical variables of the study population are summarised in Table 1. More patients with IDA lesions had HGD (9%) or CAC (27%) during their follow-up compared with the group of patients with ODA lesions (3% of HGD and 11% of CRC) (p &lt; 0,0001). Mortality was higher in patients with IDA than in those with ODA lesions (p &lt; 0.05). When comparing IBD patients with IDA lesions and CAC (=111) to those with ODA lesions and sporadic CRC (n = 15), median age at IBD diagnosis was lower (29 (IQR:22–49) vs. 41(IQR:28–54) years; p = 0.0001). Characteristics of the 1183 neoplastic lesions are summarised in Table 2. IDA lesions were more frequently non-visible, non-polypoid and ≥ 1 cm than ODA lesions (p &lt; 0.0001). ODA sporadic CRC was more frequently located in the right colon compared with IDA CAC (5/16 (31%) vs. 21/133 (16%), p &lt; 0.01). Conclusion Neoplastic lesions outside the diseased area were more likely to be visible, polypoid, &lt; 1cm, in the right colon and diagnosed at endoscopy than inside disease area lesions. A lower prevalence of HGD and Cancer were reported with neoplastic lesions outside the diseased area.

scholarly journals Advanced Treatment and Imaging in Colonoscopy: The Pocket-Creation Method for Complete Resection and Linked Color Imaging for Better Detection of Early Neoplastic Lesions by Colonoscopy

2019 ◽  
Vol 52 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Hironori Yamamoto ◽  
Satoshi Shinozaki ◽  
Yoshikazu Hayashi ◽  
Yoshimasa Miura ◽  
Tsevelnorov Khurelbaatar ◽  
...  
Keyword(s):  
Complete Resection ◽  
Advanced Treatment ◽  
Color Imaging ◽  
Neoplastic Lesions ◽  
Linked Color Imaging

scholarly journals Diagnostic ability of linked color imaging in ultraslim endoscopy to identify neoplastic lesions in the upper gastrointestinal tract

2022 ◽  
Vol 10 (01) ◽  
pp. E88-E95
Author(s):  
Ken Haruma ◽  
Mototsugu Kato ◽  
Kenro Kawada ◽  
Takahisa Murao ◽  
Shoko Ono ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Prospective Trial ◽  
Exploratory Analysis ◽  
Upper Gastrointestinal Tract ◽  
Color Imaging ◽  
Neoplastic Lesion ◽  
Multicenter Randomized Controlled Trial ◽  
Neoplastic Lesions ◽  
Linked Color Imaging ◽  
Upper Gastrointestinal

Abstract Background and study aims Linked color imaging (LCI) is a new image-enhancing technique that facilitates the differentiation of slight differences in mucosal color tone. We performed an exploratory analysis to evaluate the diagnostic capability of LCI in ultraslim endoscopy, using data from patients examined in the LCI-Further Improving Neoplasm Detection in upper gastrointestinal (LCI-FIND) trial, a large-scale, multicenter, randomized controlled trial that demonstrated the capability of LCI for detecting neoplastic lesions in the upper gastrointestinal tract. Patients and methods Data from the LCI-FIND prospective trial were used. In the LCI-FIND trial, 1502 patients with a history of gastrointestinal cancer were randomly assigned to two groups based on examination methods: white light imaging (WLI) followed by LCI (WLI group) and LCI followed by WLI (LCI group). The present exploratory analysis investigated the outcomes of patients who underwent ultraslim and standard endoscopies. Results Ultraslim endoscopes were used in 223 patients and standard endoscopes in 1279 patients. The primary endpoint of the LCI-FIND trial was the percentage of patients diagnosed with a neoplastic lesion using WLI or LCI. The corresponding percentage tended to be higher with LCI than with WLI among patients who underwent ultraslim endoscopy and among those who underwent standard endoscopy; the crude risk ratio was 2.21 [95 % confidence interval (CI): 1.06–4.67], and the adjusted odds ratio was 2.46 (95 % CI: 1.07–5.63). Conclusions Our exploratory analysis of data from the LCI-FIND trial showed that LCI is useful in identifying neoplastic lesions, when used in ultraslim endoscopy.

Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

2020 ◽  
Vol 29 (2) ◽  
pp. 175-179
Author(s):  
Melania Macarie ◽  
Simona Bataga ◽  
Simona Mocan ◽  
Monica Pantea ◽  
Razvan Opaschi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Statistical Significance ◽  
Interval Cancer ◽  
Metabolic Risk Factors ◽  
Control Group ◽  
Anatomical Site ◽  
Metabolic Risk ◽  
Right Colon ◽  
Serrated Lesions ◽  
The Right

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease. Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance. Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

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