Improved Long Term Outcomes after Heart Transplantation Utilizing Donors with Traumatic Mode of Brain Death

2018 ◽  
Vol 37 (4) ◽  
pp. S324
Author(s):  
Y. Peled ◽  
Y. Kassif ◽  
E. Raichlin ◽  
A. Kogan ◽  
Y. Har-Zahav ◽  
...  
2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Eilon Ram ◽  
Jacob Lavee ◽  
Dov Freimark ◽  
Elad Maor ◽  
Yigal Kassif ◽  
...  

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P5099-P5099
Author(s):  
S. Cohen ◽  
C. Aubailly ◽  
N. Danchin ◽  
S. Varnous ◽  
A. Pavie

2008 ◽  
Vol 27 (8) ◽  
pp. 830-834 ◽  
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Daniel Marelli ◽  
Jon Kobashigawa ◽  
Michele A. Hamilton ◽  
Jaime D. Moriguchi ◽  
Reza Kermani ◽  
...  

2019 ◽  
Vol 38 (4) ◽  
pp. S24
Author(s):  
M.D. Gilbert ◽  
P.A. Morejón ◽  
M.F. Renedo ◽  
E.F. Giordanino ◽  
L.E. Favaloro ◽  
...  

2020 ◽  
pp. jmedgenet-2020-107178
Author(s):  
Christoffer Rasmus Vissing ◽  
Torsten Bloch Rasmussen ◽  
Anne Mette Dybro ◽  
Morten Salling Olesen ◽  
Lisbeth Nørum Pedersen ◽  
...  

BackgroundTruncating variants in titin (TTNtv) are the most common cause of dilated cardiomyopathy (DCM). We evaluated the genotype-phenotype correlation in TTNtv-DCM, with a special focus on long-term outcomes, arrhythmias, response to treatment and sex-related presentation.MethodsData on patient characteristics and outcomes were collected retrospectively from electronic health records of patients genotyped at two Danish heart transplantation centres.ResultsWe included 115 patients (66% men). At diagnosis of DCM, mean age was 46±13 years and left ventricular ejection fraction (LVEF) was 28%±13%. During a median follow-up of 7.9 years, 26% reached a composite outcome of left ventricular assist device implantation, heart transplantation or death. In 20% an arrhythmia preceded the DCM diagnosis. In total, 43% had atrial fibrillation (AF) and 23% had ventricular arrhythmias. Long-term left ventricular reverse remodelling (LVRR; LVEF increase ≥10% points or normalisation) was achieved in 58% and occurred more frequently in women (72% vs 51%, p=0.042).In multivariable proportional hazards analyses, occurrence of LVRR was a strong independent negative predictor of the composite outcome (HR: 0.05 (95% CI 0.02 to 0.14); p<0.001). Female sex independently predicted lower rates of ventricular arrhythmias (HR: 0.33 (95% CI 0.11 to 0.99); p=0.05), while the location of the TTNtv was not associated with cardiovascular outcomes.ConclusionDCM caused by TTNtv presented in midlife and was associated with a high burden of AF and ventricular arrhythmias, which often preceded DCM diagnosis. Furthermore, LVRR occurred in a high proportion of patients and was a strong negative predictor of the composite outcome. Female sex was positively associated with occurrence of LVRR and longer event-free survival.


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