Non-Invasive Venous Waveform Analysis (NIVA) for Monitoring Pulmonary Capillary Wedge Pressure Post-Orthotopic Heart Transplantation: A Proof of Concept Study

2019 ◽  
Vol 38 (4) ◽  
pp. S291
Author(s):  
B.D. Alvis ◽  
T.S. Hopper ◽  
M. Polcz ◽  
K.M. Hocking ◽  
J. Whitfield ◽  
...  
2020 ◽  
Vol 9 ◽  
pp. 204800402094085
Author(s):  
Monica Polcz ◽  
Kyle M Hocking ◽  
Devin Chang ◽  
Philip Leisy ◽  
Jenna H Sobey ◽  
...  

Objectives Non-invasive venous waveform analysis (NIVA) is a recently described, novel technique to assess intravascular volume status. Waveforms are captured with a piezoelectric sensor; analysis in the frequency domain allows for calculation of a “NIVA value” that represents volume status. The aim of this report was to determine the effects of vasoactive agents on the venous waveform and calculated NIVA values. Design Porcine experimental model. Setting Operating theatre. Participants A piezoelectric sensor was secured over the surgically exposed saphenous vein in eight anesthetized pigs. Main outcome measures NIVA value, pulmonary capillary wedge pressure (PCWP), and mean arterial pressure prior to and post intravenous administration of 150–180 µg of phenylephrine or 100 µg of sodium nitroprusside. Results Phenylephrine led to a decrease in NIVA value (mean 9.2 vs. 4.6, p < 0.05), while sodium nitroprusside led to an increase in NIVA value (mean 9.5 vs. 11.9, p < 0.05). Mean arterial pressure increased after phenylephrine ( p < 0.05) and decreased after sodium nitroprusside ( p < 0.05). PCWP did not change significantly after phenylephrine ( p = 0.25) or sodium nitroprusside ( p = 0.06). Conclusions Vasoactive agents lead to changes in non-invasively obtained venous waveforms in euvolemic pigs, highlighting a potential limitation in the ability to NIVA to estimate static volume in this setting. Further studies are indicated to understand the effects of vasoactive agents in the setting of hypovolemia and hypervolemia.


PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235933 ◽  
Author(s):  
Jenna H. Sobey ◽  
Srijaya K. Reddy ◽  
Kyle M. Hocking ◽  
Monica E. Polcz ◽  
Christy M. Guth ◽  
...  

ASAIO Journal ◽  
2018 ◽  
Vol 64 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Jonathan Grinstein ◽  
Daniel Rodgers ◽  
Sara Kalantari ◽  
Gabriel Sayer ◽  
Gene H. Kim ◽  
...  

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