Comparison of Perioperative High-Sensitive Troponin T and Troponin I Assays in Cardiac Surgery

2021 ◽  
Author(s):  
Franz Masseli ◽  
Marc Masseli ◽  
Ramona Dolscheid-Pommerich ◽  
Birgit Stoffel-Wagner ◽  
Wolfgang Schiller
Keyword(s):  
Cardiac Surgery ◽  
Troponin I ◽  
Troponin T ◽  
High Sensitive Troponin

scholarly journals High sensitive troponin T as a new biomarker for atrial fibrillation development after cardiac surgery

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P2165-P2165
Author(s):  
D. Hernandez-Romero ◽  
J. A. Vilchez ◽  
A. Lahoz ◽  
A. I. Romero ◽  
E. Orenes-Pinero ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Troponin T ◽  
High Sensitive Troponin

scholarly journals Preoperative Cerebral Oxygen Saturation and Clinical Outcomes in Cardiac Surgery

2011 ◽  
Vol 114 (1) ◽  
pp. 58-69 ◽  
Author(s):  
Matthias Heringlake ◽  
Christof Garbers ◽  
Jan-Hendrik Käbler ◽  
Ingrid Anderson ◽  
Hermann Heinze ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Oxygen Saturation ◽  
Clinical Outcomes ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
Area Under The Curve ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen ◽  
Mortality And Morbidity ◽  
High Sensitive Troponin

Background The current study was designed to determine the relation between preoperative cerebral oxygen saturation (Sco2), variables of cardiopulmonary function, mortality, and morbidity in a heterogeneous cohort of cardiac surgery patients. Methods In this study, 1,178 consecutive patients scheduled for on-pump surgery were prospectively studied. Preoperative Sco2, demographics, N-terminal pro-B-type natriuretic peptide, high-sensitive troponin T, clinical outcomes, and 30-day and 1-yr mortality were recorded. Results Median additive EuroSCORE was 5 (range: 0-19). Thirty-day and 1-yr mortality and major morbidity (at least two major complications and/or a high-dependency unit stay of at least 10 days) were 3.5%, 7.7%, and 13.3%, respectively. Median minimal preoperative oxygen supplemented Sco2 (Sco2min-ox) was 64% (range: 15-92%). Sco2min-ox was correlated (all: P value <0.0001) with N-terminal pro-B-type natriuretic peptide (ρ: -0.35), high-sensitive troponin T (ρ: -0.28), hematocrit (ρ: 0.34), glomerular filtration rate (ρ: 0.19), EuroSCORE (τ: 0.20), and left ventricular ejection fraction class (τ: 0.12). Thirty-day nonsurvivors had a lower Sco2min-ox than survivors (median 58% [95% CI, 50.7-62%] vs. 64% [95% CI, 64-65%]; P < 0.0001). Receiver-operating curve analysis of Sco2min-ox and 30-day mortality revealed an area-under-the-curve of 0.71 (95% CI, 0.68-0.73%; P < 0.0001) in the total cohort and an area-under-the-curve of 0.77 (95% CI, 0.69-0.86%; P < 0.0001) in patients with a EuroSCORE more than 10. Logistic regression based on different EuroSCORE categories (0-2; 3-5, 6-10, >10), Sco2min-ox, and duration of cardiopulmonary bypass showed that a Sco2min-ox equal or less than 50% is an independent risk factor for 30-day and 1-yr mortality. Conclusions Preoperative Sco2 levels are reflective of the severity of cardiopulmonary dysfunction, associated with short- and long-term mortality and morbidity, and may add to preoperative risk stratification in patients undergoing cardiac surgery.

Distribution of soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I and high-sensitive troponin T in umbilical cord blood

2016 ◽  
Vol 54 (11) ◽  
Author(s):  
Hanah Kim ◽  
Ji Myung Kim ◽  
Mina Hur ◽  
Mi-Kyung Park ◽  
Hee-Won Moon ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord Blood ◽  
Apgar Score ◽  
Troponin I ◽  
Troponin T ◽  
Cardiac Markers ◽  
Term Neonates ◽  
High Sensitive Troponin

AbstractBackground:Soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I (hs-TnI), and high sensitive troponin T (hs-TnT) are representative cardiac biomarkers. The reference intervals (RIs) of these biomarkers have been rarely investigated in umbilical cord blood (UCB). We explored the distribution of these cardiac markers and established their RIs in UCB.Methods:In a total of 293 UCB specimens, sST2, NT-proBNP, hs-TnI, and hs-TnT concentrations were analyzed according to the gestational age, presence of premature membrane rupture (PROM), presence of gestational diabetes mellitus (GDM), and Apgar score at 1 min. Their RIs were defined in 133 UCB specimens from healthy, full-term neonates, using non-parametric percentile methods according to the Clinical and Laboratory Standards Institute guideline (EP28-A3C).Results:The concentrations of four cardiac markers in UCB were different between full-term neonates and pre-term neonates. The concentrations of NT-proBNP and hs-TnI differed according to the presence or absence of PROM. Their concentrations did not differ regardless of the presence of GDM. The concentrations of sST2 and NT-proBNP differed according to the Apgar score at 1 min. The 97.5th percentile upper reference limits were: sST2, 59.9 ng/mL; NT pro-BNP, 1415.3 pg/mL; hs-TnI, 27.8 pg/mL; and hs-TnT, 86.5 pg/mL.Conclusions:The distribution of sST2, NT pro-BNP, hs-TnI, and hs-TnT in UCB together with their RIs would provide fundamental data for future researches and clinical practice.

Interpretation of high sensitive troponin assays: acute or chronic myocardial damage?

2011 ◽  
Vol 152 (38) ◽  
pp. 1528-1534 ◽  
Author(s):  
Eszter Szánthó ◽  
Zoltán Szabó ◽  
József Varga ◽  
György Paragh ◽  
Anna V. Oláh
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Troponin I ◽  
Troponin T ◽  
Troponin Level ◽  
Cardiac Damage ◽  
Creatine Kinase Mb ◽  
Two Samples ◽  
High Sensitive Troponin

Troponin is the first choice in the diagnosis of acute myocardial infarction. Correct interpretation is challenging, because high sensitive troponin tests used today detect even the smallest cardiac damage. Methods: High sensitive troponin T (Roche) and troponin I (Mitsubishi Pathfast) and creatine-kinase activity were measured in 20 patients, each having two samples with the time lapse 3–9 hours. Results: In the group without acute myocardial infarction (n = 10) no significant increase in creatine-kinase and creatine-kinase-MB levels were seen, and the mild raise of troponins was due to other cardiovascular problems (atrial fibrillation, paroxysmal supraventricular tachycardia). With acute myocardial infarction (n = 10) a dramatic increase of troponin levels was found in the second samples, and also an increase of creatine-kinase and creatine-kinase-MB activity. According to Fischer-probe a twofold or higher increase of troponin implies 19-times higher risk of acute myocardial infarction in the case of troponin T and 8-times odds ratio at troponin I. Conclusions: The patient’s accompanying diseases should always be considered. If the troponin level is elevated, the measurement should be repeated within 3–6 hours. When troponin shows at least a twofold increase and the patient has chest pain or positive ECG, AMI is likely, and the patient needs special medical care. Although the first troponin level might be elevated if accompanying diseases cause chronic cardiac damage, it can be differentiated by a second troponin measurement. Orv. Hetil., 2011, 152, 1528–1534.

scholarly journals Incremental value of high-sensitive troponin T in addition to the revised cardiac index for peri-operative risk stratification in non-cardiac surgery

2012 ◽  
Vol 34 (11) ◽  
pp. 853-862 ◽  
Author(s):  
Michael Weber ◽  
Andreas Luchner ◽  
Seeberger Manfred ◽  
Christian Mueller ◽  
Christoph Liebetrau ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiac Index ◽  
Risk Stratification ◽  
Troponin T ◽  
Operative Risk ◽  
Incremental Value ◽  
High Sensitive Troponin

scholarly journals KINETICS OF HIGH SENSITIVE TROPONIN T (HSTNT) AFTER CARDIAC SURGERY

2015 ◽  
Vol 3 (Suppl 1) ◽  
pp. A945
Author(s):  
AS Omar ◽  
S Sudarsanan ◽  
S Hanoura ◽  
H Osman ◽  
PC Sivadasan ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Troponin T ◽  
Kinetics Of ◽  
High Sensitive Troponin

scholarly journals Discordance with 3 Cardiac Troponin I and T Assays: Implications for the 99th Percentile Cutoff

2016 ◽  
Vol 62 (8) ◽  
pp. 1106-1114 ◽  
Author(s):  
Jacobus Petrus Johannes Ungerer ◽  
Jillian Russyll Tate ◽  
Carel Jacobus Pretorius
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Reference Intervals ◽  
Cardiac Troponin I ◽  
Poor Correlation ◽  
Highly Sensitive ◽  
Analytical Imprecision ◽  
Abbott Architect ◽  
High Sensitive Troponin

Abstract BACKGROUND We compared the 99th percentile reference intervals with 3 modern cardiac troponin assays in a single cohort and tested the hypothesis that the same individuals will be identified as above the cutoff and that differences will be explained by analytical imprecision. METHODS Blood was collected from 2005 apparently healthy blood donors. Cardiac troponin was measured with Abbott Architect STAT high sensitive troponin I, Beckman Coulter Access AccuTnI+3, and Roche Elecsys troponin T highly sensitive assays. RESULTS The 99th percentile cutoff limits were as follows: Abbott cardiac troponin I (cTnI) 28.9 ng/L; Beckman Coulter cTnI 31.3 ng/L; and Roche cardiac troponin T (cTnT) 15.9 ng/L. Correlation among the assays was poor: Abbott cTnI vs Beckman Coulter cTnI, R2 = 0.18; Abbott cTnI vs Roche cTnT, R2 = 0.04; and Beckman Coulter cTnI vs Roche cTnT R2 = 0.01. Of the results above the cutoff 50% to 70% were unique to individual assays, with only 4 out of 20 individuals above the cutoff for all 3 assays. The observed differences among assays were larger than predicted from analytical imprecision. CONCLUSIONS The 99th percentile cutoff values were in agreement with those reported elsewhere. The poor correlation and concordance amongst the assays were notable. The differences found could not be explained by analytical imprecision and indicate the presence of inaccuracy (bias) that is unique to sample and assay combinations. Based on these findings we recommend less emphasis on the cutoff value and greater emphasis on δ values in the diagnosis of myocardial infarction.

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