Distribution of soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I and high-sensitive troponin T in umbilical cord blood

2016 ◽  
Vol 54 (11) ◽  
Author(s):  
Hanah Kim ◽  
Ji Myung Kim ◽  
Mina Hur ◽  
Mi-Kyung Park ◽  
Hee-Won Moon ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord Blood ◽  
Apgar Score ◽  
Troponin I ◽  
Troponin T ◽  
Cardiac Markers ◽  
Term Neonates ◽  
High Sensitive Troponin

AbstractBackground:Soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I (hs-TnI), and high sensitive troponin T (hs-TnT) are representative cardiac biomarkers. The reference intervals (RIs) of these biomarkers have been rarely investigated in umbilical cord blood (UCB). We explored the distribution of these cardiac markers and established their RIs in UCB.Methods:In a total of 293 UCB specimens, sST2, NT-proBNP, hs-TnI, and hs-TnT concentrations were analyzed according to the gestational age, presence of premature membrane rupture (PROM), presence of gestational diabetes mellitus (GDM), and Apgar score at 1 min. Their RIs were defined in 133 UCB specimens from healthy, full-term neonates, using non-parametric percentile methods according to the Clinical and Laboratory Standards Institute guideline (EP28-A3C).Results:The concentrations of four cardiac markers in UCB were different between full-term neonates and pre-term neonates. The concentrations of NT-proBNP and hs-TnI differed according to the presence or absence of PROM. Their concentrations did not differ regardless of the presence of GDM. The concentrations of sST2 and NT-proBNP differed according to the Apgar score at 1 min. The 97.5th percentile upper reference limits were: sST2, 59.9 ng/mL; NT pro-BNP, 1415.3 pg/mL; hs-TnI, 27.8 pg/mL; and hs-TnT, 86.5 pg/mL.Conclusions:The distribution of sST2, NT pro-BNP, hs-TnI, and hs-TnT in UCB together with their RIs would provide fundamental data for future researches and clinical practice.

scholarly journals Biomarkers of Atrial Fibrillation: Which One Is a True Marker?

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Pipin Ardhianto ◽  
Yoga Yuniadi
Keyword(s):  
Atrial Fibrillation ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin I ◽  
Coronary Artery Stenosis ◽  
Troponin T ◽  
Troponin Elevation ◽  
Brain Natriuretic Peptides ◽  
Prognostic Stratification ◽  
Future Events

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmias and associated with the risk of stroke and death. Continuous development of the diagnostic tool and prognostic stratification may lead to optimal management of AF. The use of biomarkers in the management of AF has been grown as an interesting topic. However, the AF biomarkers are not yet well established in the major guidelines. Among these biomarkers, a lot of data show troponin and brain natriuretic peptides are promising for the prediction of future events. The troponin elevation in AF patients may not necessarily be diagnosed as myocardial infarction or significant coronary artery stenosis, and brain natriuretic peptide elevation may not necessarily confirm heart failure. Troponin T and troponin I may predict postoperative AF. Furthermore, troponin and brain natriuretic peptide gave better prognostic performance when compared with the risk score available today.

High-sensitive troponin T and N-terminal-brain-natriuretic-peptide predict outcome in symptomatic aortic stenosis

2012 ◽  
Vol 46 (5) ◽  
pp. 278-285 ◽  
Author(s):  
Ole Geir Solberg ◽  
Thor Ueland ◽  
Ragnhild Wergeland ◽  
Christen P. Dahl ◽  
Svend Aakhus ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
High Sensitive Troponin

Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery

2009 ◽  
Vol 281 (5) ◽  
pp. 907-912 ◽  
Author(s):  
Won Joon Seong ◽  
Douk Hun Yoon ◽  
Gun Oh Chong ◽  
Dae Gy Hong ◽  
Tae Bon Koo ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Mode Of Delivery ◽  
Amino Terminal

Serum Cardiac Troponins and N-Terminal Pro-Brain Natriuretic Peptide: A Staging System for Primary Systemic Amyloidosis

2004 ◽  
Vol 22 (18) ◽  
pp. 3751-3757 ◽  
Author(s):  
Angela Dispenzieri ◽  
Morie A. Gertz ◽  
Robert A. Kyle ◽  
Martha Q. Lacy ◽  
Mary F. Burritt ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Elevated Serum ◽  
Staging System ◽  
Systemic Amyloidosis ◽  
Prognostic Models ◽  
Plasma Cell Dyscrasia

Purpose Primary systemic amyloidosis (AL) is a multisystemic disorder resulting from an underlying plasma cell dyscrasia. There is no formal staging system for AL, making comparisons between studies and treatment centers difficult. Our group previously identified elevated serum cardiac troponin T (cTnT) as the most powerful predictor of overall survival. Others have reported that N-terminal pro-brain natriuretic peptide (NT-proBNP) is a valuable prognostic marker. We sought to develop a staging system for patients with AL. Patients and Methods Two hundred forty-two patients with newly diagnosed AL who were seen at the Mayo Clinic between April 1979 and November 2000, and who had echocardiograms and stored serum samples at presentation were eligible for this retrospective review. NT-proBNP measurements were performed on 242 patients in whom cTnT and cardiac troponin I (cTnI) had been previously run. Two prognostic models were designed using threshold values of NT-proBNP and either cTnT or cTnI (NT-proBNP < 332 ng/L, cTnT < 0.035 μg/L, and cTnI < 0.1 μg/L). Depending on whether NT-proBNP and troponin levels were both low, were high for only one level, or were both high, patients were classified as stage I, II, or III, respectively. Results Using the cTnT+NT-proBNP model 33%, 30%, and 37% of patients were stages I, II, and III, respectively, with median survivals of 26.4, 10.5, and 3.5 months, respectively. The alternate cTnI+NT-proBNP model predicted median survivals of 27.2, 11.1, and 4.1 months, respectively. Conclusion Stratification of AL patients into three stages is possible with two readily available and reproducible tests setting the stage for more consistent and reliable cross comparisons of therapeutic outcomes.

scholarly journals Associations of brain–natriuretic peptide, high–sensitive troponin T, and high–sensitive C–reactive protein with outcomes in severe aortic stenosis

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179304 ◽  
Author(s):  
Andreas Auensen ◽  
Amjad Iqbal Hussain ◽  
Ragnhild Sørum Falk ◽  
Marte Meyer Walle-Hansen ◽  
Jorun Bye ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
Severe Aortic Stenosis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
High Sensitive Troponin

scholarly journals EVALUATION OF BIOCHEMICAL AND OXIDATIVE STRESS MARKERS AS PREDICTIVE TOOL FOR DIAGNOSIS OF BIRTH ASPHYXIA AND ENCEPHALOPATHY IN NEW BORN

2021 ◽  
Vol 9 (10) ◽  
pp. 891-897
Author(s):  
Shweta Singh ◽  
◽  
Babita Singhal ◽  
Bhumika Upadhyay ◽  
Chandra Mohan Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Apgar Score ◽  
Oxidative Stress Markers ◽  
Term Neonates ◽  
Mean Values ◽  
Stress Markers ◽  
The Mean ◽  
And Oxidative Stress

Background:Birth asphyxia and resultanthypoxic ischemic encephalopathy (HIE), are leading cause of mortality and morbidity in newborns. Delayed diagnosis may lead to progression of HIE as its clinical features may not be evident at birth as they evolve with time. This study was done to identify asphyxia and HIE in term neonates by evaluating biochemical and oxidative stress markers in umbilical cord blood sample taken immediately after delivery. Methodology: This prospective cross sectional study was done on term neonates in a tertiary care hospital (n=60)Thestudy population was then divided into two equal groups on the basis of Apgar score at 1 minute, with score < 7 as cases (n=30) and ≥7 as controls ( n=30) . The umbilical cord blood was evaluated for biochemical and oxidative stress markers like lactate dehydrogenase (LDH), creatine kinase brain isoform (CK BB), superoxide dismutase (SOD,malondialdehyde (MDH) and catalase. Result: The mean values of LDH, CK BB, and MDA were higher in cases than controls and the differences were highly significant statistically. The mean values of SOD and catalase were higher in cases than controls and the differences were significant statistically. However, mean value of LDH & CKBB of cases with prolonged asphyxia with Apgar score < 7 at 5 minutes (n=4) versus cases with Apgar score > 7 (n=26) was not statistically significant at 95% CI. Conclusion: This study helps in diagnosis of neonatal asphyxia at an early stage thereby preserving the normal functioning of neonatal brain so that the brain functioning is not compromised.

1518: Troponin T and N-Terminal Pro-Brain Natriuretic Peptide (PRO-BNP) Changes in Patients Undergoing Transurethral Resection of The Prostate (TURP)

2004 ◽  
Vol 171 (4S) ◽  
pp. 399-400
Author(s):  
Ramaswamy Manikandan ◽  
Calvin Nathaniel ◽  
Ravi Gullipalli ◽  
Adebanji Adeyoju ◽  
Stephen C.W. Brown ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Transurethral Resection ◽  
Troponin T
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